Journals / MN Oftalmoloji / 2007 / Cilt: 14 - Sayı: 3

Late stage ocular surface findings in lamotrigine ınduced Stevens-Johnson syndrome : A case report

Lamotrijine bağlı Stevens-Johnson sendromlu bir olgunun geç dönem göz bulguları

Pages
216–218
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, we aimed to present late stage ocular findings of a case with Stevens-Johnson syndrome, which developed following the lamotrigine treatment.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Stevens-Johnson syndrome is a rare, acute, allergic, life-threatening disease, characterized with target and bulluous lesion in the skin and mucoza.
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Key Findings & Data:Ocular involvement manifest itself as conjunctivitis in early stage, but as dry eye and serious corneal problems in late stage.
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Conclusion & Impact:In this study, we aimed to present late stage ocular findings of a case with Stevens-Johnson syndrome, which developed following the lamotrigine treatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Erişkin · Erkek · Stevens-Johnson sendromu

Abstract

Stevens-Johnson syndrome is a rare, acute, allergic, life-threatening disease, characterized with target and bulluous lesion in the skin and mucoza. Ocular involvement manifest itself as conjunctivitis in early stage, but as dry eye and serious corneal problems in late stage. Lamotrigine is a drug used for bipolar regulatory and anticonvulsant purpose. In this study, we aimed to present late stage ocular findings of a case with Stevens-Johnson syndrome, which developed following the lamotrigine treatment.

Özet

Stevens-Johnson sendromu, deri ve mukozalarda hedef lezyonlar ve büllerle seyreden, hayatı tehdit edebilen, nadir, akut, allerjik bir reaksiyondur. Oküler tutulum genellikle erken dönemde konjonktivit, geç dönemde kuru göz ve ciddi korneal problemlerle kendini gösterir. Lamotrijin, duygu durum dengeleyici ve antikonvülzan amaçla kullanılan bir ilaçtır. Bu çalışmada lamotrijine bağlı Stevens-Johnson sendromu gelişen bir olgunun geç dönemdeki oküler yüzey bulgularını sunmak amaçlandı.

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Cite This Article

KEKLİKÇİ, U., ÜNLÜ, K., YAŞAN, A., ÇAKMAK, S. S., ŞAKALAR, Y. B. (2007). Late stage ocular surface findings in lamotrigine ınduced Stevens-Johnson syndrome : A case report. MN Oftalmoloji, Cilt: 14 - Sayı: 3, 216–218. https://ajindex.com/articles/296864

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References (10)

  1. Mockenhaupt M, Messenheimer J, Tennis P, Schlingmann J. Risk of Stevens-Johnson syndrome and toxic epidermal nec rolysis in new users of antiepileptics. Neurology 2005;12; 64:1134-8
  2. Yip LW, Thong BY, Lim J. et al. Ocular manifestations and complications of Stevens-Johnson syndrome and toxic epi dermal necrolysis: an Asian series. Allergy 2007; 62:527-31
  3. Uğuz A, Berber Z, Haspolat Ş, ve ark. Lamotrijine Bağlı Stevens-Johnson Sendromu-Toksik Epidermal Nekroliz: Bir Olgu Sunumu. T Klin Pediatri 2005; 14:36-9
  4. Messenheimer JA. Rash in adult and pediatric patients trea ted with lamotrigine. Can J Neurol Sci 1998; 25:14-8
  5. Örnek K, Atilla H, Erkam N. Lamotrijine Bağlı Toksik Epidermal Nekroliz ve Ağır Göz Tutulumu. MN Oftalmoloji 2002; 9:396-8
  6. Pelit A, Akova Y. Stevens Johnson Sendromunda Göz Bulguları ve Tedavisi. T Klin J Med Sci 2004; 24:284-8
  7. Shen YC, Chen SJ, Lin CC, Chen CH. Concomitant use of la motrigine and aripiprazole increases risk of Stevens-Johnson syndrome? Int Clin Psychopharmacol 2007; 22:247-8
  8. Kocak S, Girisgin SA, Gul M, Cander B, Kaya H, Kaya E. Stevens-Johnson syndrome due to concomitant use of la motrigine and valproic acid. Am J Clin Dermatol 2007; 8: 107-11
  9. Yalcin B, Karaduman A. Stevens-Johnson syndrome asso ciated with concomitant use of lamotrigine and valproic acid. J Am Acad Dermatol 2000; 43:898-9
  10. Haefliger IO, Vysniauskiene I, Pimentel AR, Soares EJ,Piffaretti JM. Free autologous buccal mucosal graft transp lantation to treat ocular complications after toxic epidermal necrolysis: case report. Klin Monatsbl Augenheilkd 2004; 22:395-7.