SavedAdd your journal

Journals / MN Oftalmoloji / 2007 / Cilt: 14 - Sayı: 1

Comparison of the effects of combined topical nonsteroidal antiinflamatory drugs and antibiotic preparates in traumatic corneal abrasion cases

Travmatik korneal hasarlarda kombine topikal antibiyotik ve antiinflamatuar preparatların etkinliklerinin karşılaştırılması

Ayça SARI
Esmahan BİRDAL
Ayşegül ARMAN
Pages
75–78
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In cases where both analgesic and antibiotic effects are required both topical combined forms of drugs are found to be effective and safe.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: To determine the efficacy of indomethacin 5 mg+ gentamicin sulfate 15000 IU (group 1) or diclofenac sodium %0.1+ tobramycine %0.3 (group 2) preparates in traumatic corneal abrasion cases.
📊
Key Findings & Data:Material And Method: Two groups of 25 eyes with unilateral traumatic corneal abrasion were treated.
💡
Conclusion & Impact:Conclusion: In cases where both analgesic and antibiotic effects are required both topical combined forms of drugs are found to be effective and safe.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tobramisin · İlaç uygulama · topikal

Abstract

Purpose: To determine the efficacy of indomethacin 5 mg+ gentamicin sulfate 15000 IU (group 1) or diclofenac sodium %0.1+ tobramycine %0.3 (group 2) preparates in traumatic corneal abrasion cases. Material And Method: Two groups of 25 eyes with unilateral traumatic corneal abrasion were treated. The patients were asked to score their subjective complaints on a scale of 0 to 3 in the day they applied (day 0) and the next day (day 1). The objective findings were also evaluated and recorded by the same physician. Results: A statistically significant decrease in both objective and subjective scores was found on day 1 in both groups. There was no significant difference between the 2 groups. Conclusion: In cases where both analgesic and antibiotic effects are required both topical combined forms of drugs are found to be effective and safe.

Özet

Amaç: Travmatik korneal epitel hasarı nedeniyle tedavi amaçlı kombine indometasin 5 mg + gentamisin sulfat 15000 IU (grup 1) veya diklofenak sodyum %0.1+ tobramisin %0.3 (grup 2) başlanan olgu gruplarındaki subjektif ve objektif bulguların karşılaştırılması. Gereç ve Yöntem: Tek taraflı travmatik korneal epitel hasarı ile başvurmuş olgulardan her grup için retrospektif ve randomize olarak seçilmiş 25’er olgu seçilmiştir. Olgulardan başvurdukları gün (0.gün) ve 1. günde subjektif yakınmalarını 0’dan 3’e kadar olan bir skalada derecelendirmeleri istenmiş, objektif bulgular ise tek hekim tarafından derecelendirilerek kaydedilmiştir. Bulgular: Subjektif ve objektif skor ortalamaları arasında 2 grupta da istatiksel olarak anlamlı bir düşüş izlenmiş olup (p<0.05) gruplar arasında anlamlı fark saptanmamıştır. Sonuç: Analjezik ve antibiyotik etkinliğin birlikte gerektiği travmatik korneal hasarlarda kombine formda bulunan her 2 preparatın da eşit derecede etkin ve güvenilir olduğu görülmüştür.

🔖

Cite This Article

SARI, A., BİRDAL, E., ARMAN, A. (2007). Comparison of the effects of combined topical nonsteroidal antiinflamatory drugs and antibiotic preparates in traumatic corneal abrasion cases. MN Oftalmoloji, Cilt: 14 - Sayı: 1, 75–78. https://ajindex.com/articles/296854

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Alberti MM, Bouat CG, Allaire CM, TrinQuand CJ.Combined indomethacin/ gentamicin eyedrops to reduce pain after traumatic corneal abrasion. Eur J Ophthalmol 2001
  2. Yang Z, Zhao Z, Panjwani N. Gangliosides of migrating and nonmigrating corneal epithelium in organ and cell culture. Invest Ophthalmol Vis Sci 1996
  3. Assouline M, Renard G, Arne JL. A prospective randomized trial of topical soluble 0.1% indomethacin versus 0.1% diclofenac versus placebo for the control of pain following excimer laser photorefractive keratectomy. Ophthalmic Surg Lasers 1998
  4. Goes F, Richard C, Trinquand C. Comparative study of two non-steroidal anti-inflammatory eyedrops,0.1% indometn cin versus 0.1% diclofenac in pain control in post photo-refractive keratectomy. Bull Soc Belge Ophthalmöl 1998
  5. Killer HE, Blumer B, Mayers M. Comparison of the anti-inflammatory potency and local tolerance of diclofenac and indomethacin eye drops in the postoperative management of patients undergoing ECCE with PCL. Ocular immunology and Inflammation 1993
  6. Leibowitz HM, Kupferman A. Drug interaction in the eye. Concurrent corticosteroid- antibiotic therapy for inflammatory keratitis. Arch Ophthalmol 1977
  7. Schoenwald RD, Haris RG, Turner D, Knowles W, Chien DS. Ophthalmic bioequivalance of steroid/antibiotic combination formulations. Biopharm Drug Dispos 1985
  8. Leibowitz HM,Pratt MV, Flagstad IJ, Berrospi AR, Kundsin R. Human conjunctivitis II treatment. Arch Ophthalmol 1976
  9. Kantor TG. Current modalities in arthritic disease. Am J Med 1987
  10. 83(Suppl4B):2-5. 10.Ferreira SH, Moncada S, Vane JR. Prostaglandins and the mechanism of analgesia, produced by aspirin-like drugs. Br J Pharmacol 1973
  11. Laitinen J, Nuutinen L, Kiiskila EL, Freudental Y, Ranta P. Comparison of intravenous diclofenac, indomethacin and oxycodone as post-operative analgesics in patients undergoing knee surgery. Eur J Anaesth 1992
  12. Bellamy N, Bensen WG, Ford PM, Huang SH, Lang JY. Double-blind randomized controlled trial of flurbiprofen_SR and diclofenac sodium-SR in the treatment of osteoarthritis. Clin Invest Med 1992
  13. Scholer DW, Ku EC, Boettcher I, Schweizer A. Pharmacology of diclofenac sodium. Am J Med 1986
  14. 80 (suppl):34-8. 14.Martini A, Bondiolotti GP, Sacerdote P. Diclofenac increases beta-endorphin plasma concentrations. J Int Med Res 1984
  15. Bazan HEP. The synthesis and effects of