Journals / MN Oftalmoloji / 1999 / Cilt: 6 - Sayı: 3

Histopathologic results of experimental glaucoma in rabbit eyes

Tavşanlarda deneysel glokomun histopatolojik olarak değerlendirilmesi

Pages
222–224
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings became more prominent with the duration of glaucoma.

📌 3 Key Takeaways

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Objective & Hypothesis:PURPOSE: To evaluate the histopathologic results of experimental glaucoma in rabbit eyes.
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Key Findings & Data:METHODS: Experimental glaucoma was induced in 9 eyes of 10 rabbits by injecting alpha chymotrypsin into the posterior chamber of the right eyes.
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Conclusion & Impact:These findings became more prominent with the duration of glaucoma.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tavşanlar · Kimotripsin · Optik disk

Abstract

PURPOSE: To evaluate the histopathologic results of experimental glaucoma in rabbit eyes. METHODS: Experimental glaucoma was induced in 9 eyes of 10 rabbits by injecting alpha chymotrypsin into the posterior chamber of the right eyes. For histological assessments, globes were enucleated at first week, 15th day, 1 st, 2nd and 3rd months after alpha chymotrypsin injection. RESULTS: Prominent retinal degeneration was found 15 days after enzyme injection. Cupping of the optic disc appeared after 1 month. CONCLUSION: Retinal ganglion cell loss and cupping of the optic disc were noted. These findings became more prominent with the duration of glaucoma.

Özet

AMAÇ: Deneysel olarak glokom oluşturulmuş tavşan gözlerini histopatolojik olarak değerlendirmektir. YÖNTEM: Deneysel glokom 10 tavşanın 9'unda, sağ gözlerine alfa-kimotripsin enjeksiyonu yapılarak oluşturulmuştur. 1 hafta, 15 gün, 1 ay, 2 ay ve 3 ay sonra enüklee edilen gözlerden alınan 5 mikronluk kesitler ışık mikroskobunda incelenmiştir. BULGULAR: Alfa-kimotripsin enjeksiyonundan 15 gün sonra belirgin retinal dejenerasyon, 1 ay sonrada optik diskte çukurlaşma gözlenmiştir. SONUÇ: Retinal ganglion hücrelerinde azalma ve optik diskte ekskavasyon artışı tespit edilmiş, bu bulgularda glokom süresiyle paralel olarak artış belirlenmiştir.

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Cite This Article

AKYOL, İ., ERDOĞAN, F., KOÇER, İ., GÜLLÜLÜ, G., KELEŞ, M. (1999). Histopathologic results of experimental glaucoma in rabbit eyes. MN Oftalmoloji, Cilt: 6 - Sayı: 3, 222–224. https://ajindex.com/articles/296533