Journals / MN Oftalmoloji / 2004 / Cilt: 11 - Sayı: 2

Plasma homocysteine levels in type II diabetes mellitus with retinopathy and neovascular glaucoma

Tip II diabetik preproliferatif retinopati ve neovasküler glokomu olan hastalarda plazma homosistein düzeyleri

Pages
145–148
DOI
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Any significant difference could not be detected between homocysteine levels of preproliferative retinopathy and neovascular glaucoma groups Conclusions: It was thought that hyperhomocysteinemia may be a risk factor for type II diabetic microvascular lesions but it did not seem a valuable marker which indicates the progression of lesions observed in neovascular glaucoma .

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To evaluate plasma homocysteine levels being a risk factor for microvascular lesions and its role for the progression of microvascular lesions seen in type II diabettes mellitus.
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Key Findings & Data:Material and Methods: Plasma homocysteine levels of NIDDM patients with preproliferative retinopathy (n=20) and neovascular glaucoma (n=20) were determined.
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Conclusion & Impact:Any significant difference could not be detected between homocysteine levels of preproliferative retinopathy and neovascular glaucoma groups Conclusions: It was thought that hyperhomocysteinemia may be a risk factor for type II diabetic microvascular lesions but it did not seem a valuable marker which indicates the progression of lesions observed in neovascular glaucoma .
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Homosistein · Glokom · neovasküler

Abstract

Purpose: To evaluate plasma homocysteine levels being a risk factor for microvascular lesions and its role for the progression of microvascular lesions seen in type II diabettes mellitus. Material and Methods: Plasma homocysteine levels of NIDDM patients with preproliferative retinopathy (n=20) and neovascular glaucoma (n=20) were determined. Flouressence polarisation immunoassay method were used to determine homocysteine levels by Abbot IMX instrument. Results: Type II diabetic patients (preproliferative retinopathy and neovascular glaucoma group, n=40) had higher plasma homocystein levels than those of controls (n=30) (p<0.01). There was no significant difference between homocystein levels of preproliferative retinopathy and control groups. Homocysteine levels of neovascular glaucoma group were found significantly higher than those of control group (p<0.001). Any significant difference could not be detected between homocysteine levels of preproliferative retinopathy and neovascular glaucoma groups Conclusions: It was thought that hyperhomocysteinemia may be a risk factor for type II diabetic microvascular lesions but it did not seem a valuable marker which indicates the progression of lesions observed in neovascular glaucoma .

Özet

Amaç: Tip II diabetes mellitusda plazma homosistein düzeyinin; küçük damar lezyonları için risk faktörü olup olmadığını ve küçük damar lezyonunun ilerlemesindeki rolünü değerlendirmek. Gereç ve Yöntem: Tip II diabetli 20 preproliferatif retinopatili ve 20 neovasküler glokomlu hastanın plazma homosistein düzeyleri ölçüldü. Plazma homosistein düzeyleri floresan polarizasyon immunoassay yöntemi ile, Abbot IMX cihazında ölçüldü. Bulgular: Tip II diabetik hastaların (preproliferatif retinopati ve neovasküler glokomlu, n=40) plazma homosistein düzeyleri kontrollerden (n=30) anlamlı derecede daha yüksek bulundu (p<0.01). Preproliferatif retinopati ve kontrol gruplarının homosistein düzeyleri arasında anlamlı fark bulunamadı. Neovasküler glokom grubunun homosistein düzeyleri kontrol grubundan anlamlı olarak yüksek bulundu (p<0.001). Preproliferatif retinopati ve neovasküler glokom gruplarının homosistein düzeyleri arasında anlamlı fark bulunamadı. Sonuç: Hiperhomosisteineminin tip II diabetteki küçük damar damar lezyonları için bir risk faktörü olabileceği fakat neovasküler glokomda gözlenen retinopatinin ilerlemesini göstermesi açısından değerli bir belirteç olmadığı düşünüldü.

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Cite This Article

YÜCEL, İ., YÜCEL, G., MÜFTÜOĞLU, F. (2004). Plasma homocysteine levels in type II diabetes mellitus with retinopathy and neovascular glaucoma. MN Oftalmoloji, Cilt: 11 - Sayı: 2, 145–148. https://ajindex.com/articles/296172

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