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Journals / MN Oftalmoloji / 2011 / Cilt: 18 - Sayı: 2

Retinal nerve fiber layer thickness and macular thickness in amblyopic eyes

Ambliyopide retina sinir lifi ve maküla kalınlığı

Emine ÇATAK
Huban ATİLLA
Reşat DUMAN
Pages
127–131
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Therefore it can be concluded that amblyopia does not have an effect on the thickness of the fovea and peripapillary nerve fiber layer and low visual acuity of the amblyopic eyes can not be explained by the anatomical changes of the nerve fiber layer.

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Objective & Hypothesis:Aim: To compare the peripapillary retinal nerve fiber layer (RNFL) thickness and central macular thickness (CMT) of amblyopic and presumed normal eyes with optic coherence tomography (OCT) in amblyopic subjects.
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Key Findings & Data:Material and Method: In this prostective study, 50 eyes of 25 patients who were diagnosed as amblyopia for the first time between March and May 2010 at Ankara University Pediatric Ophthalmology and Strabismus Deparment were included.
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Conclusion & Impact:Therefore it can be concluded that amblyopia does not have an effect on the thickness of the fovea and peripapillary nerve fiber layer and low visual acuity of the amblyopic eyes can not be explained by the anatomical changes of the nerve fiber layer.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: To compare the peripapillary retinal nerve fiber layer (RNFL) thickness and central macular thickness (CMT) of amblyopic and presumed normal eyes with optic coherence tomography (OCT) in amblyopic subjects. Material and Method: In this prostective study, 50 eyes of 25 patients who were diagnosed as amblyopia for the first time between March and May 2010 at Ankara University Pediatric Ophthalmology and Strabismus Deparment were included. A detailed ophthalmologic examination, keratometry, axial length measurement and RNFL, CMT measurements with OCT (Cirrus-Carl Zeiss) were performed in all subjects. The peripapillary RNFL, SMT and axial length measurements were compared between the amblyopic and fellow eyes. Results: The average age of the patients was 14.5 years (7-30). Lateralization in 11 amblyopic eyes were right and 14 eyes were left. According to the etiology; 68% of the cases had anisometropia, 20% had strabismus and12% had deprivation due to ptosis and congenital cataract. The peripapillary RNFL thickness in amblyopic eyes were (respectively inferior, superior, nasal, temporal quadrants) 122.3±20.4μm, 116.3±18.8 μm, 65.9±14.2 μm, 68.3±23.8 μm, in the fellow eye 124.0±19.2 μm, 117.9±16.8 μm, 69.9±15.6 μm, 65.6±13.1 μm. The mean CMT of the amblyopic and fellow normal eyes was 249.2±30.8 μm and 258.5 ±37.6 μm. The mean axial length was 22.0±1.5 mm in amblyopic eyes and 22.6±1.0 mm in fellow eyes. Regarding the peripapillary RNFL, CMT and axial length measurements, there were no statistically significant difference between the amblyopic and the fellow eyes. Conclusion: In this study between different types of amblyopia no significant difference was found between amblyopic and normal fellow eyes regarding the peripapillary RNFL, CMT and axial length measurements. Therefore it can be concluded that amblyopia does not have an effect on the thickness of the fovea and peripapillary nerve fiber layer and low visual acuity of the amblyopic eyes can not be explained by the anatomical changes of the nerve fiber layer.

Özet

Amaç: Ambliyop olgularda, ambliyop ve sağlam kabul edilen diğer gözdeki retina sinir lifi tabakası (RSLT) ve santral maküla kalınlığının (SMK), optik koherans tomografi (OKT) yöntemi ile ölçülerek sonuçlarının karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya Mart 2010-Mayıs 2010 tarihleri arasında, Ankara Üni ver si - tesi Tıp Fakültesi Pediyatrik Oftalmoloji ve Şaşılık Servisi’ne ilk kez başvuran ve ambliyopi tanısı alan 25 hastanın 50 gözü dahil edildi. Tüm olgulara tam bir oftalmolojik muayene, keratometri, aksiyel uzunluk ölçümü Orbscan (Alcon) ve OKT (Cirrus-Carl Zeiss) ile peripapiller RSLT ve SMK ölçümü yapıldı. Hastaların ambliyop gözleri ile diğer gözleri RSLT kalınlığı, SMK ve aksiyel uzunluk yönünden karşılaştırıldı. Bulgular: Çalışmaya dahil edilen olguların yaş ortalaması 14,56 yıl (7-30) idi. Olguların 11’inde (%44) sağ göz, 14’ünde (%56) sol göz ambliyop idi. Etyolojiye göre değerlendirildiğinde; olguların %68’inde anizometropi, %20’sinde şaşılık ve %12’sinde deprivasyon ambliyopisi vardı. Ambliyop gözdeki peripapiller RSLT kalınlığı kadranlara göre (sırası ile alt, üst, nazal, temporal) 122,3±20,4μm, 116,3±18,8 μm, 65,9±14,2 μm, 68,3±23,8 μm iken, diğer gözde 124,04±19,2 μm, 117,9±16,8 μm, 69,9±15,6 μm, 65,6±13,1 μm olarak bulundu. Ortalama SMK ise, ambliyopik gözde 249,2±30,8 μm iken, diğer gözde 258,5±37,6 μm idi. Ambliyop gözdeki aksiyel uzunluk 22,0±1,5 mm iken diğer gözde 22,6±1,0 mm olarak ölçüldü. Tüm ölçümlerde aradaki farklar istatistiksel olarak anlamlı bulunmadı. Sonuç: Bu çalışmada farklı etyolojiye bağlı ambliyopilerde, daha az gören ambliyop gözler ile diğer gözler arasında RSLT kalınlığı, SMK ve aksiyel uzunluk yönünden anlamlı fark bulunmadığı ve az görmenin sinir lifi tabakasındaki anatomik değişiklik ile açıklanamayacağı düşünülebilir.

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Cite This Article

ÇATAK, E., ATİLLA, H., DUMAN, R. (2011). Retinal nerve fiber layer thickness and macular thickness in amblyopic eyes. MN Oftalmoloji, Cilt: 18 - Sayı: 2, 127–131. https://ajindex.com/articles/295773

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