Journals / MN Oftalmoloji / 2019 / Cilt: 26 - Sayı: 1

Early Changes in Retinal Nerve Fiber Layer Thickness in Patients with Type 1 Diabetes Without Diabetic Retinopathy

Diyabetik Retinopati Gelişmemiş Tip 1 Diyabetli Hastalarda Retina Sinir Lifi Tabakası Kalınlığında Erken Dönemde Gelişebilecek Değişiklikler

Pages
12–36
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Thinner retinal nerve fiber laye in diabetic patients may indicate that metabolic controls in these patients are irregular.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We aimed to investigate early changes that may occur in the retinal nerve fiber layer thickness in patients with type 1 diabetes who have not developed diabetic retinopathy.
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Key Findings & Data:Material and Method: Sixty patients with type 1 diabetes and thirty healthy individiuls were included in the study.
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Conclusion & Impact:Thinner retinal nerve fiber laye in diabetic patients may indicate that metabolic controls in these patients are irregular.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to investigate early changes that may occur in the retinal nerve fiber layer thickness in patients with type 1 diabetes who have not developed diabetic retinopathy. Material and Method: Sixty patients with type 1 diabetes and thirty healthy individiuls were included in the study. Thirty patients diagnosed with diabetes mellitus in less than 10 years were included in group 1, and thirty patients diagnosed for 10 years or longer were identified as group 2. Age, gender, refraction, visual acuity, intraocular pressure, central corneal thickness, duration of diabetes, HbA1c, serum glucose lev- els were recorded. Retinal nerve fiber laye thickness was measured in 4 different quadrants. One way Anova test were used for statistical analy- sis, p<0.05 was considered significant. Results: In group 1; the mean age of thirty patients (17 female, 13 male) with diabetes mellitus was 25.3 ± 4.2 years; the mean age of thirty patients (19 female, 11 male) was 27.1 ± 3.6 years in group 2. The mean age of thirty healthy individuals (18 female, 12 male) was 24.8 ± 3.1 years. In group 1, 2 and control group retinal nerve fiber laye thickness values was average; 100.3 ± 5.7 μm, 97.5 ± 8.5 μm, 106.4 ± 6.2 μm, inferior quadrant; 128 ± 11.6 μm, 110 ± 9.3 μm, 135 ± 14.7 μm, superior quadrant; 118.3 ± 14.13 μm, 105 ± 11.3 μm, 130.3 ± 15.12 μm, nasal quadrant; 85±12.9 μm, 87 ± 12.3 μm, 87±15.8 μm, temporal quadrant; 70.3 ± 9.2 μm, 72.1 ± 8.7 μm, 74.2 ± 10.3 μm respectively. Conclusion: Compared to the control group; we found that the retinal nerve fiber laye thicknesses of patients in group 1 and group 2 were thinner. We think that the thinning of retinal nerve fiber laye in early period may be related to irregular metabolic control of the patients and the duration of diabetes. Thinner retinal nerve fiber laye in diabetic patients may indicate that metabolic controls in these patients are irregular.

Özet

Amaç: Diyabetik retinopati gelişmemiş tip 1 diyabetli hastalarda retina sinir lifi tabakası kalınlığında erken dönemde gelişebilecek deği- şiklikleri araştırmayı amaçladık. Gereç ve Yöntem: 60 tip 1 diyabetli hasta ve 30 sağlıklı birey çalışmaya dahil edildi. Diyabetli hastalardan 10 yıldan daha kısa süredir tanı alan 30 hasta; grup 1, 10 yıl ve daha uzun süredir tanı alan 30 hasta; grup 2 olarak belirlendi. Tip 1 diyabetli haricinde sistemik ya da oküler hastalık hikayesi olanlar, indirekt oftalmoskopla yapılan fundus muayenesinde diyabetik retinapatisi olan hastalar çalışmaya alınmadı. Yaş, cin- siyet, refraksiyon, görme keskinliği, göz içi basıncı, santral korneal kalınlık, diyabetli süresi, HbA1c, serum glikoz seviyeleri kaydedildi. Retina si- nir lifi tabakası kalınlığı 4 farklı kadranda ölçüldü. İstatistiksel analizlerde One way Anova testi kullanıldı, p<0,05 olması anlamlı kabul edildi. Bulgular: Grup 1’de 17’si kadın, 13’ü erkek 30 diyabetli hastanın yaş ortalaması 25,3±4,2, grup 2’de 19’u kadın 11’i erkek 30 diyabetli hastanın yaş ortalaması 27,1 ± 3,6, kontrol grubunda ise 18’i kadın, 12’si erkek 30 sağlıklı bireyin yaş ortalaması 24,8±3,1 idi. Tüm hastaların sağ gözleri değerlendirildi. Grup 1, grup 2 ve kontrol grubunda retina sinir lifi tabakası kalınlık değerleri sırasıyla; ortalama; 100,3±5,7 μm, 97,5±8,5 μm, 106,4±6,2 μm, alt kadran; 128±11,6 μm, 110±9,3 μm 135±14,7 μm, üst kadran; 118,3±14,13 μm, 105±11,3 μm, 130,3 ± 15,12 μm, nazal kadran; 85±12,9 μm, 87±12,3 μm, 87±15,8 μm, temporal kadran; 70,3±9,2 μm, 72,1±8,7 μm, 74,2±10,3 μm idi. Sonuç: Kontrol grubuyla kıyaslandığında; grup 1 ve grup 2’deki hastaların retina sinir lifi tabakası kalınlıklarının daha ince olduğu be- lirlenmiştir. Erken dönemde retina sinir lifi tabakasındaki incelmenin; olguların metabolik kontrollerinin düzensiz olması ve diyabetin süresi ile ilişkili olabileceğini düşünmekteyiz. Diyabetik hastaların retina sinir lifi tabakası kalınlığındaki incelme, bu hastalardaki metabolik kontrollerin düzensiz olduğunu gösterebilir.

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Cite This Article

ONDAS, O., BOZKURT, E. (2019). Early Changes in Retinal Nerve Fiber Layer Thickness in Patients with Type 1 Diabetes Without Diabetic Retinopathy. MN Oftalmoloji, Cilt: 26 - Sayı: 1, 12–36. https://ajindex.com/articles/295358

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