In our study, we aimed to reveal the relationship between habitual abortion with folate and vitamin B12 levels.
📌 3 Key Takeaways
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Objective & Hypothesis:Objective: Although several pathophysiological mechanisms are defined in the etiology of habitual abortion, still causes half of the cases haven’t been clarified yet.
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Key Findings & Data:It has been reported that folate and vitamin B12 are effective in early pregnancy complications.
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Conclusion & Impact:In our study, we aimed to reveal the relationship between habitual abortion with folate and vitamin B12 levels.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Folat · Habitüel abort · Vitamin B12
Abstract
Objective: Although several pathophysiological mechanisms are defined in the etiology of habitual abortion, still causes half of the cases haven’t been clarified yet. It has been reported that folate and vitamin B12 are effective in early pregnancy complications. In our study, we aimed to reveal the relationship between habitual abortion with folate and vitamin B12 levels.
Özet
Amaç: Habitüel abortus etiyolojisinde birçok patofizyolojik mekanizma tanımlanmış olsa da vakaların yarısının nedeni hala aydınlatılamamıştır. Folat ve B12 vitamininin erken gebelik komplikasyonları üzerinde etkili olduğu bildirilmektedir. Biz de çalışmamızda habitüel abortus ile folat ve vitamin B12 düzeyleri arasındaki ilişkiyi ortaya koymayı amaçladık.
YILMAZ, Z., GÜVEY, H., ÇELIK, S., ÇALIŞKAN, C. S., YAŞAR, B., YAZICIOĞLU, B., TÜRE, E., ULUBAŞOĞLU, H. (2021). The Role of Vitamin B12 and Folate in Habitual Abortion. Online Türk Sağlık Bilimleri Dergisi, Cilt: 6 - Sayı: 3, 347–352. https://ajindex.com/articles/293852
Von Eye Corleta H. It is time to respect the American Society for Reproductive Medicine definition of recurrent pregnancy loss. Fertil Steril. 2010;94(4):e61. doi:10.1016/j.fertnstert. 2010.06.020 Regan L, Backos M, Rai R. Royal College of Obstetricians & Gynaecologists. The investigation and treatment of couples with recurrent first-trimester and second trimester miscarriage. Guideline No. 17, 2011. https://www.rcog.org.uk/globalassets/documents/guidelines/gtg_17.pdf. Accessed November 8, 2020.
Fritz M, Goldberg J, McClure RD et al. The Practice Committee of the American Society for Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion. 2012. https://www.fertstert.org/action/showPdf?pii=S0015-0282%2812%2900701-7. Accessed November 8,2020.
Silver RM, Branch DW, Goldenberg R, Iams JD, Klebanoff MA. Nomenclature for pregnancy outcomes Time for a change. American Collage of Obsterics and Gynecology. 2011;118(6):1402-1408. doi:10.1097/AOG.0b013e3182392977 Pei C, Kim YJ, Baek K. Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects. Obstet Gynecol. 2019;62(4):212-223. doi:10.5468/ogs.2019.62.4.212 Solé-Navais P, Cavallé-Busquets P, Fernandez-Ballart JD, Murphy MM. Early pregnancy B vitamin status, one carbon metabolism, pregnancy outcome and child development. Biochimie. 2016;126:91-96. doi:10.1016/j.biochi.2015.12.003 Yang T, Gu Y, Wei X et al. Periconceptional folic acid supplementation and vitamin B 12 status in a cohort of Chinese early pregnancy women with the risk of adverse pregnancy outcomes. J Clin Biochem Nutr. 2017;60(2):136-142. doi:10.3164/jcbn.16-45
Sukumar N, Rafnsson SB, Kandala N, Bhopal R, Yajnik CS, Saravanan P. Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta analysis. Am J Clin Nutr. 2016;103:1232-1251. doi:10.3945/ajcn.115.123083 Dror DK, Allen LH. Interventions with Vitamins B6, B12 and C in pregnancy. Pediatr Perinat Epidemiol. 2012;26(1):55-74. doi:10.1111/j.1365-3016.2012.01277.x George L, Mills JL, Johansson ALV, et al. Plasma folate levels and risk of spontaneous abortion. J Am Med Assoc. 2002;288(15):1867-1873. doi:10.1001/jama.288.15.1867. Mujawar SA, Patil VW, Daver RG. Study of serum homocysteine, folic acid and vitamin B12 in patients with preeclampsia. Indian J Clin Biochem. 2011;26(3):257-260. doi:10.1007/s12291-011-0109-3
Puri M, Kaur L, Walia GK, Mukhopadhhyay R, Pal M. MTHFR C