Journals / Okmeydanı Tıp Dergisi / 2012 / Cilt: 28 - Sayı: 2

The association between C-Reactive protein levels and severity of the disease in stable chronic obstructive pulmonary disease patients

Stabil kronik obstrüktif akciğer hastalığında hastalık ağırlığı ile C-reaktif protein düzeyi arasındaki ilişki

Pages
103–107
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In our study, the relationship between systemic inflammation and stage of the disease in stable COPD patients has been shown.It was concluded that higher levels of CRP were associated with higher stage of the disease.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of the study was to evaluate the relationship between C-Reactive Protein (CRP) levels and severity of disease in patients with chronic obstructive pulmonary disease (COPD).
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Key Findings & Data:Methods: Fifty-three stable COPD patients (38 males-15 females) with median age of 56.19±9.87 years were included in the study.
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Conclusion & Impact:Conclusion: In our study, the relationship between systemic inflammation and stage of the disease in stable COPD patients has been shown.It was concluded that higher levels of CRP were associated with higher stage of the disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of the study was to evaluate the relationship between C-Reactive Protein (CRP) levels and severity of disease in patients with chronic obstructive pulmonary disease (COPD). Methods: Fifty-three stable COPD patients (38 males-15 females) with median age of 56.19±9.87 years were included in the study. Patients were divided as a Group 1 (Stage I-II) with 31 patients and Group 2 (Stage III-IV) with 22 patients. Group 1 and 2 were compared according to CRP levels detected in the stable period. Results: There was a significant correlation between the stage of COPD and the levels of CRP. CRP levels were significantly higher in Group 2 (Stage III-IV) COPD patients than Group 1 (p<0.01). Conclusion: In our study, the relationship between systemic inflammation and stage of the disease in stable COPD patients has been shown.It was concluded that higher levels of CRP were associated with higher stage of the disease.

Özet

Amaç: Çalışmamızda Kronik Obstrüktif Akciğer Hastalığı (KOAH) olan hastalarda hastalığın ağırlığı ile C-reaktif protein (CRP) düzeyi arasında ilişki olup olmadığı araştırıldı. Yöntemler: Stabil durumda KOAH’ı olan 53 hasta (38 erkek-15 kadın), yaş ortalaması 56.19±9.87 olan çalışmaya dahil edildi. Çalışmaya alınan hastalar Grup 1 (Evre I-II 31 hasta), Grup 2 (Evre III-IV 22 hasta) olarak 2 gruba ayrıldı. Grup 1 ve Grup 2’deki hastalar CRP düzeyleri açısından karşılaştırıldı. Bulgular: KOAH evresi ile CRP düzeyi arasında anlamlı ilişki saptandı. Grup 2 (Evre III-IV) KOAH grubunda CRP düzeyi, Grup 1 (Evre I-II) olgulara göre anlamlı derecede daha yüksek bulundu (p<0.01). Sonuç: Çalışmamızda; stabil KOAH olgularındaki sistemik inflamasyonun hastalık evresi ile ilişkili olduğu gösterildi. Artmış CRP düzeylerinin hastalık evresi artışı ile birlikte olduğu sonucuna varıldı.

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Cite This Article

AYNACI, A., AYNACI, E., YILDIZ, B. P., ORTAKÖYLÜ, G., ÇAĞLAR, E. (2012). The association between C-Reactive protein levels and severity of the disease in stable chronic obstructive pulmonary disease patients. Okmeydanı Tıp Dergisi, Cilt: 28 - Sayı: 2, 103–107. https://ajindex.com/articles/291881

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References (13)

  1. Broekhuizen R, Wouters EFM, Creutzberg EC, Schols AMWJ. Raised CRP levels mark metabolic and functional impairment in advanced COPD. Thorax 2006
  2. 61(1):17-22. http://dx.doi.org/10.1136/thx.2005.041996 PMid:16055618 PMCid:2080712 2. Pepys MB, Hirschfield GM. C-reactive protein. A critical update. J Clin Invest 2003
  3. PMid:12813013 PMCid:161431 3. Malo O, Sauleda J, Busquets X, et al. Systemic inflammation during exacerbations of chronic obstructive pulmonary disease. Arch Bronconeumol 2002
  4. PMid:11953269 4. Hutchinson WL, Koe GW, Frochlich M, et al. Immunoradiometric assay of circulating C-reactive protein: Age-related values in the adult general population. Clin Chem 2000
  5. Vigushin DM, Pepys MB, Hawkins PN. Metabolic and scintigraphic studies of radioiodinated human C-reaktive protein, in health and disease. J Clin Invest 1993
  6. http://dx.doi.org/10.1172/JCI116336 PMid:8473487 PMCid:288106 6. Donaldson GC, Seemungal TAPatel IS, et al. Airway and systemic inflammation and decline in lung function in patients with COPD. Chest 2005
  7. 128(4):1995-2004. http://dx.doi.org/10.1378/chest.128.4.1995 PMid:16236847 7. Wedzicha JA, Seemungal TA, MacCallum PK, et al. Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinojen and serum IL-6 levels. Thromb Haemost 2000
  8. PMid:10959691 8. Folsom AR. Epidemiology of fibrinogen. Eur Heart J 1995
  9. 16(suppl A):21-24. 9. De Maat MP, Pietersma A, Kofflard M, et al. Association of plasma fibrinogen levels with coronary artery disease, smoking and inflammatory markers. Atherosclerosis 1996
  10. http://dx.doi.org/10.1016/0021-9150(95)05716-1 10. Minoguchi K, Yokoe T, Tazaki T, et al. Increased carotid intima-media thickness and serum inflammatory markers in obstructive sleep apnea. Am J Respir Crit Care Med 2005
  11. 172(5):625-630. http://dx.doi.org/10.1164/rccm.200412-1652OC PMid:16120716 11. Thakore AH, Guo CY, Larson MG, et al. Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study). Am J Cardiol 2007
  12. 99(11):1598-1602. http://dx.doi.org/10.1016/j.amjcard.2007.01.036 PMid:17531588 12. Hiroyasu I, Shimamoto T, Sato S. Passive Smoking and Plasma Fibrinojen Concentrations. Am J Epidemiol 1996
  13. http://dx.doi.org/10.1093/oxfordjournals.aje.a008893 PMid:8956627 13. Mannino DM, Ford ES, Redd SC. Obstructive and restrictive lung disease a