Journals / Okmeydanı Tıp Dergisi / 2015 / Cilt: 31 - Sayı: 0

Effects of Diabetes Mellitus on Neurological Disorders

Diyabet ve Nörolojik Hastalıklar

Pages
45–51
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The objective of this paper is to describe the neurological complications of diabetes mellitus and emphasize the importance of patient education in good diabetic control and early diagnosis in preventing these complications.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Diabetes mellitus is one of the most common diseases in the world having unfavorable effects on the patients.
📊
Key Findings & Data:Poor diabetic control increases the risk of neuropathy which can be prevented by education of patients.
💡
Conclusion & Impact:The objective of this paper is to describe the neurological complications of diabetes mellitus and emphasize the importance of patient education in good diabetic control and early diagnosis in preventing these complications.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Diabetes mellitus is one of the most common diseases in the world having unfavorable effects on the patients. It is associated with a number of neurological conditions including peripheral nerve disorders, stroke and dementia. Peripheral nerve disorders are the most common complications of diabetes mellitus. Poor diabetic control increases the risk of neuropathy which can be prevented by education of patients. The association between DM and dementia appears to be stronger for vascular cognitive impairment than for Alzheimer's disease, suggesting cerebrovascular disease may be an important factor in cognitive impairment in DM. Although the exact mechanisms by which DM affects the brain remain unclear, changes to brain vasculature, disturbances of cerebral insulin signaling, insulin resistance, glucose toxicity, oxidative stress, accumulation of advanced glycation end products, hypoglycemic episodes, and alterations in amyloid metabolism may all be involved. The objective of this paper is to describe the neurological complications of diabetes mellitus and emphasize the importance of patient education in good diabetic control and early diagnosis in preventing these complications.

Özet

Diabetes mellitus hâlen dünyada oldukça sık görülen bir hastalık olup, hastaların günlük yaşamlarını olumsuz etkilemektedir. Diyabetin periferik sinir hastalıkları, inme ve demans gibi nörolojik hastalıklarla da ilişkisi bilinmektedir. Bunların arasında en sık görülen hastalık periferik sinir hastalığı olup, kötü diyabetik kontrolün oluşum riskini arttırdığı ve hastaların eğitimi ile önlenebileceği bildirilmiştir. Diyabetli hastalarda vasküler demans Alzheimer hastalı- ğından daha sık görülmekte ve bu nedenle serebrovasküler hastalıkların diyabetteki kognitif yıkımla ilişkili olabileceği düşünülmektedir. Diyabetin beyni etkileme mekanizmaları net olarak ortaya konmamakla birlikte, damar yapısının etkilenmesi, insülin rezistansı, glukoz toksisitesi, oksidatif stres, glikolizasyon son ürünlerinin birikimi, hipoglisemik epizodlar ve amiloid metabolizmasındaki değişikliklerin etkili olduğu düşünülmektedir. Bu makalenin amacı, diyabetin nörolojik komplikasyonlarını tanımlamak ve bu komplikasyonların önlenmesinde hasta eğitimi, iyi diyabet kontrolünün sağlanması ve erken tanının önemini vurgulamaktır.

🔖

Cite This Article

ÜNAL, E., AKAN, O., ÜÇLER, S. (2015). Effects of Diabetes Mellitus on Neurological Disorders. Okmeydanı Tıp Dergisi, Cilt: 31 - Sayı: 0, 45–51. https://ajindex.com/articles/291772

References (7)

  1. Said G. Diabetic neuropathy-A Review. Nat Clin Prac Neurol 2007;3:331-340. http://dx.doi.org/10.1038/ncpneuro0504 Albers JW. Diabetic Neuropathy: Mechanisms, Emer- ging Treatments and Subtypes. Curr Neurol Neurosci- Rep 2014;14:473. http://dx.doi.org/10.1007/s11910-014-0473-5 Charnogursky G. Neurological Complications of diabe- tes. Curr Neurol Neurosci Rep 2014;14:457. http://dx.doi.org/10.1007/s11910-014-0457-5 Emre M. Nöroloji Temel Kitabı, birinci baskı. bölüm 2. 2013;535-540. Zarko S. Amınoff M.Neurology and General Medicine. 4. baskı (395-405).
  2. Idris I, Thomson GA, Sharma JC. Diabetes mellitus and stroke. Int J Clin Pract 2006;60(1):48-56. http://dx.doi.org/10.1111/j.1368-5031.2006.00682.x
  3. Rohit R. Das, MD, Seshadri S. Diabetes and Stroke. DM Current Cardiovascular Risk Reports 2009;3:35- 41. Merel JA, Biessels GJ. Diabetes, hyperglycaemia, an- dacute ischaemic stroke, Lancet Neurol 2012;11:261- 271. http://dx.doi.org/10.1016/S1474-4422(12)70005-4
  4. Kernan WN, Ovbiagele B, Black HR. Guidelines for the Prevention of Stroke in patients with stroke and Transient Ischemic Attack. DOI:10.1161/STR.000000000000002 29.World Health Organization and Alzheimer's Disease International. Dementia. A public health priority. Ava- ilable at: http://www.who.int/mental_health/publicati- ons/dementia_report_2012/en/.Accessed 18 Aug 2013.
  5. Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 2006;5:64-74. http://dx.doi.org/10.1016/S1474-4422(05)70284-2 Ninomiya T. Diabetes mellitus and dementia: Curr Diab Rep 2014;14:487. http://dx.doi.org/10.1007/s11892-014-0487-z Stewart R. Cardiovascular factors in Alzheimer's disea- se. J Neurol Neurosurg Psychiatry 1998;65:143-147. http://dx.doi.org/10.1136/jnnp.65.2.143
  6. Launer LJ, Miller ME, Williamson JD, et al. Effects of intensive glucose lowering on brain structure and- function in people with type 2 diabetes (accordmind): a randomize dopen-labelsub study. Lancet Neurol 2011;10:969-972 http://dx.doi.org/10.1016/S1474-4422(11)70188-0 de Galan BE, Zoungas S, Chalmers J, et al. ADVANCE Collaborative Group. Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascu- lar Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial. Diabetologia 2009;52:2328-2336. http://dx.doi.org/10.1007/s00125-009-1484-7
  7. Zhao WQ, Alkon DL. Role of insulinandinsuli