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Journals / Organic Communications / 2020 / Cilt: 13 - Sayı: 1

ZrCl4-catalyzed one-pot multi-component synthesis of hexahydropyrano pyrimidinone derivatives

Parshuram M. PİSAL
Ajay S. SAWANT
Vinod T. KAMBLE
Ravi VARALA
Syed F. ADİL
Mujeeb KHAN
Mohammed Rafiq H. SİDDİQUİ
Pages
28–32
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This method has various benefits such as easy availability of starting materials, lower cost, higher yield and shorter reaction time.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, zirconium tetrachloride is used as a highly efficient catalyst for the one-pot three component reaction of 3,4-dihydro(2H)-pyran, urea and benzaldehyde in ethanol, producing corresponding hexahydropyrano pyrimidinone derivatives in good yields, with excellent diastereoselectivity.
📊
Key Findings & Data:In this study, zirconium tetrachloride is used as a highly efficient catalyst for the one-pot three component reaction of 3,4-dihydro(2H)-pyran, urea and benzaldehyde in ethanol, producing corresponding hexahydropyrano pyrimidinone derivatives in good yields, with excellent diastereoselectivity.
💡
Conclusion & Impact:This method has various benefits such as easy availability of starting materials, lower cost, higher yield and shorter reaction time.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

In this study, zirconium tetrachloride is used as a highly efficient catalyst for the one-pot three component reaction of 3,4-dihydro(2H)-pyran, urea and benzaldehyde in ethanol, producing corresponding hexahydropyrano pyrimidinone derivatives in good yields, with excellent diastereoselectivity. This method has various benefits such as easy availability of starting materials, lower cost, higher yield and shorter reaction time.

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Cite This Article

PİSAL, P. M., SAWANT, A. S., KAMBLE, V. T., VARALA, R., ADİL, S. F., KHAN, M., SİDDİQUİ, M. R. H. (2020). ZrCl4-catalyzed one-pot multi-component synthesis of hexahydropyrano pyrimidinone derivatives. Organic Communications, Cilt: 13 - Sayı: 1, 28–32. https://ajindex.com/articles/288476

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References (13)

  1. Erlanson, D. A.; McDowell, R. S.; O'Brien, T. Fragment-based drug discovery. J. Med. Chem. 2004, 47 (14), 3463-3482
  2. Spring, D. R. Chemical genetics to chemical genomics: Small molecules offer big insights. Chem. Soc. Rev. 2005, 34 (6), 472-482
  3. Galloway, W. R. J. D.; Isidro-Llobet, A.; Spring, D. R. Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules. Nat. Commun. 2010, 1 (6), 1 -13
  4. David, B.; Wolfender, J.-L.; Dias, D. A. The pharmaceutical industry and natural products: Historical status and new trends. Phytochem. Rev. 2015, 14 (2), 299-315
  5. Butler, M. S. The role of natural product chemistry in drug discovery. J. Nat. Prod. 2004, 67 (12), 2141 - 2153
  6. Davoll, J.; Clarke, J.; Elslager, E. F. Antimalarial substances
  7. Folate antagonists. 4.Antimalarial and antimetabolite effects of 2,4-diamino-6-[(benzyl)amino]pyrido[2,3-d]pyrimidines. J. Med. Chem. 1972, 15 (8), 837-839
  8. Grivsky, E. M.; Lee, S.; Sigel, C. W.; Duch, D. S.; Nichol, C. A. Synthesis and antitumor activity of 2,4- diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine.J. Med. Chem. 1980, 23 (3), 327-329
  9. Broom, A. D.; Shim, J. L.; Anderson, G. L. Pyrido[2,3-d]pyrimidines. IV. Synthetic studies leading to various oxopyrido[2,3-d]pyrimidines. J. Org. Chem. 1976, 41 (7), 1 095-1099
  10. Ghorab, M. M.; Hassan, A. Y. Synthesis and antibacterial properties of new dithienyl containing pyran, pyrano[2,3-b] pyridine, pyrano[2,3-d]pyrimidine and pyridine derivatives. Phosphor. Sulfur Sil. Rel. Elem. 1998, 141 (1), 251 -261. [1 0] Furuya, S.; Ohtaki, T. Pyrido[2,3-d]pyrimidines and their use as endothelin antagonists. Eur. Patent 1994, 608565. [1 1 ] Coates, W. Preparation of pyrimidopyrimidine derivatives useful as bronchodilators, vasodilators, antiallergic. Eur. Patent 1990, 351058. [1 2] Kitamura, N.; Onishi, A. Eur. Patent 1984,163599
  11. Levitt, G. Herbicidal sulfonamides. In Denmark Patents: 1 979: DK401878A [14] Anastas, P. T.; Heine, L. G.; Williamson, T. C. Green Chemical Syntheses and Processes: Introduction. In Green Chemical Syntheses and Processes, ed.; American Chemical Society: 2000; Vol. 767
  12. Kaur, R.; Chaudhary, S.; Kumar, K.; Gupta, M. K.; Rawal, R. K. Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review. Eur. J. Med. Chem. 2017, 132, 108
  13. Maiti, B.; Chanda, K. Diversity oriented synthesis of benzimidazole-based biheterocyclic molecules by combinatorial