Journals / Organic Communications / 2020 / Cilt: 13 - Sayı: 2

Efficient synthesis and characterization of novel isoxazole derivatives including dihdyropyrazole and methanoisoindole moieties

Pages
57–64
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, the synthesis and characterization of a series of novel hybrid molecules containing pyrazole and isoxazole rings ((3aS,4S,4aR,7aS,8S,8aS)-6-(4-(1-acetyl-5-(4- (aryl/heteroaryl))-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-3-methyl-4,4a,8,8a-tetrahydro-3aH-4,8-methanoisoxazolo [4,5-f] isoindole-5,7(6H,7aH)-dione derivatives) were reported.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Isoxazole and pyrazole derivatives have a wide range of biological activity and they are of great interest to medicinal chemist.
📊
Key Findings & Data:Isoxazole and pyrazole derivatives have a wide range of biological activity and they are of great interest to medicinal chemist.
💡
Conclusion & Impact:In this study, the synthesis and characterization of a series of novel hybrid molecules containing pyrazole and isoxazole rings ((3aS,4S,4aR,7aS,8S,8aS)-6-(4-(1-acetyl-5-(4- (aryl/heteroaryl))-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-3-methyl-4,4a,8,8a-tetrahydro-3aH-4,8-methanoisoxazolo [4,5-f] isoindole-5,7(6H,7aH)-dione derivatives) were reported.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Isoxazole and pyrazole derivatives have a wide range of biological activity and they are of great interest to medicinal chemist. In this study, the synthesis and characterization of a series of novel hybrid molecules containing pyrazole and isoxazole rings ((3aS,4S,4aR,7aS,8S,8aS)-6-(4-(1-acetyl-5-(4- (aryl/heteroaryl))-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-3-methyl-4,4a,8,8a-tetrahydro-3aH-4,8-methanoisoxazolo [4,5-f] isoindole-5,7(6H,7aH)-dione derivatives) were reported.

🔖

Cite This Article

GÜRDERE, M. B., ERTÜRK, F., BUDAK, Y., CEYLAN, M. (2020). Efficient synthesis and characterization of novel isoxazole derivatives including dihdyropyrazole and methanoisoindole moieties. Organic Communications, Cilt: 13 - Sayı: 2, 57–64. https://ajindex.com/articles/288457

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. Özbek, O.; Usta, N.C.; Gürdere, M.B.; Aslan, O.N.; Budak, Y.; Ceylan, M. Synthesis and antibacterial screening of novel 2-(4-(aryl) thiazol-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-ethanoisoindole-1,3(2H)-dione derivatives. Phosphor. Sulfur Silic. Relat. Elem. 2017, 192, 1153-1157
  2. Gürdere, M.B.; Kamo, E.; Budak, Y.; Sahin Yağlıoğlu, A.; Ceylan, M. Synthesis and anticancer and cytotoxic effects of novel 1,4-phenylene-bis-N-thiocarbamoylpyrazole and 1,4-phenylene-bispyrazolylthiazole derivatives. Turk. J. Chem. 2017, 41, 179-189
  3. Yakalı, G.; Karabıyık, H.; Göksu, G.; Aygün M.; Öcal, N.; García-Granda, S. Supramolecular chiralitysensing DNA-mimicry of a norbornane derivative decorated with isoxazoline and methylpyrolidine-2,5- dione ring. J. Mol. Struct. 2013, 1041, 164-174
  4. Gürdere, M.B.; Özbek, O.; Ceylan, M. Aluminum chloride–catalyzed C-alkylation of pyrrole and indole with chalcone and bis-chalcone derivatives. Synt. Commun. 2016, 46, 322-331
  5. Budak, Y.; Çakir A.D.; Özbek, O.; Gürdere, M.B.; Ceylan, M. Iodine-catalyzed addition of thiophenol to isoindolsubstitue chalcones. BSEU J. Sci. 2020, 7, 161-169
  6. Ye, N.; Zhu, Y-M.; Chen, H-J.; Liu, Z.; Mei, F. C.; Wild, C.; Chen, H.; Cheng, X.; Zhou, J. Structureactivity relationship studies of substituted 2-(Isoxazol-3-yl)-2-oxo-N′-phenyl-acetohydrazonoyl cyanide analogues: Identification of potent exchange proteins directly activated by cAMP (EPAC) antagonists. J. Med. Chem. 2015, 58, 6033-6047
  7. Pankaj, V.; Khairnar, T.H.; Lung, Yi-J.; Lin, C.-Y.; Wu, S. R.; Koppolu, A.; Edukondalu, P.; Karanam, W. L. An intramolecular Wittig approach toward heteroarenes: Synthesis of pyrazoles, isoxazoles, and chromenone-oximes. Org. Lett. 2019, 21(11), 4219-4223
  8. Daidone, G.; Raffa, D.; Maggio, B.; Plesica, F.; Cutili, V.M; Mangano, N.G.; Casuro, A. Synthesis and pharmacological activities of novel 3-(isoxazol-3-yl)-quinazolin-4(3H)-one derivatives. Arch. Pharm. 1999, 332, 50-54
  9. Bibi, H.; Nadeem, H.; Abbas, M. Synthesis and anti-nociceptive potential of isoxazole carboxamide derivatives. BMC Chem. 2019, 29, 13(1):6
  10. Çalışkan, B.; Sinoplu, E.; İbiş, K.; Güzelcan, A. E.; Atalay, Ç. R.; Banoglu, E. Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents J. Enzyme Inhib. Med. Chem. 2018, 33(1), 1352-1361
  11. Pallepati, K.; Kancharlapalli, V. R.; Shaik, A. B. Synthesis, characterization and antitubercular evaluation of some