AI Summary & Key Takeaways
AI InsightThe clinicopathologic features of an infant who presented with hyperinsulinemic hypoglycemia, died at the age of 18 days and had nesidioblastosis diagnosed by autopsy are presented and histopathological diagnostic difficulties are discussed together with the literature.
📌 3 Key Takeaways
Abstract
The morphoiogical abnormalities of the endocrine pancreas that underlie Persistent Neonatal Hyperinsulinemic Hypoglycemia (PNHH) and are included under the heading " nesidioblastosis" appear to be heterogeneous. Nesidioblastosis is the process of differentiation of pancreatic islets from ductular epithelium. The clinicopathologic features of an infant who presented with hyperinsulinemic hypoglycemia, died at the age of 18 days and had nesidioblastosis diagnosed by autopsy are presented and histopathological diagnostic difficulties are discussed together with the literature.
Özet
Persistan Neonatal Hiperinsülinemik Hipogliseminin (PNHH) altta yatan endokrin pankreas patolojileri "Nesidioblastosis" başlığı altında toplanır ve heterojen bir gruptur. Nesidioblastosis pankreasın duktal epitelinin pankreas adacıklarına differansiyasyonu sürecidir. Bu makalede hiperinsülinemik hipoglisemi ile seyreden, 18 günlükken eksitus olan ve otopsi ile nesidioblastosis ve atnalı böbrek tanısı konan erkek infantın klinikopatolojik özellikleri sunulmuş ve histopatolojik tanı güçlükleri literatür bilgisi eşliğinde tartışılmıştır.