Extensive chondroid differentiation in a Wilms tumor following chemotherapy: Clinical relevance and implications

Reporting of such cases is extremely important to recognize tumor morphological heterogeneity, particularly postchemotherapy, and developing consensus for selecting further treatment and clinical follow-up.

📌 3 Key Takeaways

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Objective & Hypothesis:Wilms tumor (WT) is the most common childhood tumor of the kidney, which histologically mimics various stages of nephrogenesis.

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Key Findings & Data:Spectrum of chemotherapy induced histopathological changes has been described in literature, and is one of the most important predictors of disease outcome and survival rates.

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Conclusion & Impact:Reporting of such cases is extremely important to recognize tumor morphological heterogeneity, particularly postchemotherapy, and developing consensus for selecting further treatment and clinical follow-up.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Özet

Wilms tumor (WT) is the most common childhood tumor of the kidney, which histologically mimics various stages of nephrogenesis. Spectrum of chemotherapy induced histopathological changes has been described in literature, and is one of the most important predictors of disease outcome and survival rates. Extensive chondroid differentiation and absence of necrosis in a post-chemotherapy nephrectomy specimen of a radiologically proven Wilms tumor is an unusual finding. Herein, we present the case of 6-year-old girl from South Africa who received a 10-week course of chemotherapy upon radiological diagnosis of WT, and post-surgery nephrectomy specimen revealed extensive mature cartilage island formation on histology raising diagnostic dilemma. Reporting of such cases is extremely important to recognize tumor morphological heterogeneity, particularly postchemotherapy, and developing consensus for selecting further treatment and clinical follow-up.

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Cite This Article

KUMARI, K., NARANJE, P., NAKRA, T., KAUSHAL, S., ROY, D., DAVERA, S., AGARWALA, S., BISWAS, A., IYER, V. K., DINDA, A. K. (2020). Extensive chondroid differentiation in a Wilms tumor following chemotherapy: Clinical relevance and implications. Pediatric Urology Case Reports, Cilt: 7 - Sayı: 1, 1–6. https://ajindex.com/articles/285530

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