Journals / İbn-i Sina Tıp Dergisi / 2002 / Cilt: 7 - Sayı: 3

Ekstrakorporeal sirkülasyonda intravenöz insülinle hiperkaleminin tedavisi

Treatment of hyperkalaemia with intravenous insulin during extracorporeal circulation

Pages
150–154
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was concluded that insulin in the dose of 25 units can be used safely in the treatment of hypercalcemia during ECC.

📌 3 Key Takeaways

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Objective & Hypothesis:Glucose-insulin infusion can be used in the treatment of hypercalcemiaseen in extracorporeal circulation (ECC) during cardiac surgery.
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Key Findings & Data:We aimed to investigate the rate of decrease in blood potassium level with two different doses of insulin in hyperkalaemic patients during ECC.
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Conclusion & Impact:It was concluded that insulin in the dose of 25 units can be used safely in the treatment of hypercalcemia during ECC.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hiperkalsemi · Vücut dışı dolaşım · İnsülin

Abstract

Glucose-insulin infusion can be used in the treatment of hypercalcemiaseen in extracorporeal circulation (ECC) during cardiac surgery. We aimed to investigate the rate of decrease in blood potassium level with two different doses of insulin in hyperkalaemic patients during ECC. Thirty six hyperkalaemic patients, to whom continuous retrograde warm blood cardioplegia was applied, were allocated to the study. Patients having blood potassium level of 7 mmol/L and above were allocated to the group I and of 6-6.9 mmol/L to group II. Fifty units of insulin was given intravenously as a bolus dose to the group I patients and 25 units to the group II patients. Blood potassium and glucose levels were monitored. The time to get the blood potassium level of 5.5 mmol / L, and the complications were investigated. The time to get blood potassium level of 5.5 mmol/L was 22.7$\pm$1.9 min in group I, and 15.7$\pm$0.8 min in group II. The decrease in potassium level was 1.78 mmol/L and the rate of decrease in blood potassium level was 0.078 mmol /L /min in group I, and 0.76 mmol /L and 0.048 mmol/L/min in group II, respectively. Complication (hypopotassemia and hypoglycemia) rate was higher in group I. It was concluded that insulin in the dose of 25 units can be used safely in the treatment of hypercalcemia during ECC.

Özet

Kardiak cerrahi esnasında ekstrakorporeal sirkülasyonda (ECC) görülen hiperkaleminin tedavisinde glukoz - insülin infüzyonu kullanılabilir. ECC de hiperkalemik hastalarda iki farklı dozda insülinle kan potasyum düzeyindeki azalma hızını incelemeyi amaçladık. Devamlı retrograd sıcak kan kardioplejisi uygulanan 36 hasta çalışmaya dahil edildi. Kan potasyum düzeyi 2 mmol/L ve üzeri olanlar grup 1'i ve 6-6.9 mmol/L olanlar grup 2'yi oluşturdu. Grup 1 hastalara 50 ünite insulin bolus dozda intravenöz olarak, grup 2'ye 25 ünite verildi. Kan potasyum ve glukoz düzeyleri takip edildi. Kan potasyum düzeyinin 5.5 mmol/L'ye düşme zamanı ve komplikasyonlar incelendi. Kan potasyum düzeyinin 5.5 mmol/L'ye ulaşma zamanı grup 1'de 22.7$\pm$1.9 dak. ve grup 2'de 15.7$\pm$0.8 dak. idi. Grup 1'de potasyum düzeyindeki azalma 1.78 mmol/L, azalma hızı 0.078 mmol/dak grup 2'de ise sırasıyla 0.76 mmol/L ve 0.048 mmol/L/dak idi. Komplikasyon (hipopotasemi ve hipoglisemi) oranı grup I'de daha yüksekti. ECC'de hiperkalemi tedavisinde 25 ünitelik insulin dozunun emniyetle kullanılabileceği sonucuna varıldı.

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Cite This Article

KOÇOĞLU, H., PENÇE, S., GÖKSU, S., SOYKAN, B., KOÇAK, T., YILMAZ, N. (2002). Ekstrakorporeal sirkülasyonda intravenöz insülinle hiperkaleminin tedavisi. İbn-i Sina Tıp Dergisi, Cilt: 7 - Sayı: 3, 150–154. https://ajindex.com/articles/284923

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