Diagnosis and management in hyperandrogenism: Review

Objective & Hypothesis:Hyperandrogenism is the increase in production and/or the augmentation of the activity of androgens. 10-20% of women suffer from hyperandrogenism in a period of their lives.

📊

Key Findings & Data:Ovary and adrenal glands are the most important sources of androgen in women.

💡

Conclusion & Impact:This text is a review of pathophysiology, clinical diagnosis and the treatment strategies of hyperandrogenism.

🔬Design:Review & Systematic Survey

📍Scope:Comprehensive Sample

⚙️Variables:Hirsutizm · Hiperandrojenizm · Hirsutism

Abstract

Hyperandrogenism is the increase in production and/or the augmentation of the activity of androgens. 10-20% of women suffer from hyperandrogenism in a period of their lives. Ovary and adrenal glands are the most important sources of androgen in women. One of the most important issue in the assessment of hyperandrogenism in women is the determination of ovarian disorders. Main symptoms of hyperandrogenism in women are masculine somatic variations. Hyperandrogenism can be suspected by the presense of hirsutism and acne clinically. Also leads to menstrual disorders by effecting ovulatory function. This text is a review of pathophysiology, clinical diagnosis and the treatment strategies of hyperandrogenism.

Özet

Hiperandrojenizm, kadında androjen yapımının fazlalaşması ve/veya androjen aktivitesinin artmasıdır. Kadınların %10-20'si hayatlarının herhangi bir döneminde androjen fazlalığı ve bunun klinik problemleri ile karşılaşmaktadır. Kadınlarda androjenlerin en önemli iki kaynağı over ve adrenal glandlardır. Jinekolojide androjen metabolizması bozukluklarının değerlendirilmesinde en önemli amaç overe ait androjen metabolizması bozukluklarının tanımlanmasıdır. Androjen fazlalığı, kadınlarda başlıca erkeksi somatik değişimlerle ortaya çıkmaktadır. Klinik olarak, hirsutizm ve aknenin olması hiperandrojenizmin araştırılması için yeterli gerekçelerdir. Hiperandrojenizm, ovulatuar bozukluklara da yol açarak menstruel siklus bozuklukları ile beraber olabilir. Bu derlemede androjen fazlalığının patofizyolojisi, klinik tanı ve tedavi yöntemlerinden bahsedilmektedir.

Keywords

Hirsutizm Hiperandrojenizm Hirsutism Hyperandrogenism

🔖

Cite This Article

DUVAN, Z. C. İ., ŞİMŞEK, E., ÇETİNKAYA, E., VARDAR, G. (2005). Diagnosis and management in hyperandrogenism: Review. Medical Network Klinik Bilimler ve Doktor, Cilt: 11 - Sayı: 5, 560–567. https://ajindex.com/articles/279602

References (1)

Adashi EY, Levin PA: Pathophysiology and evaluation of ıdrenal hiperandrogenism. Semin Reprod Endocrinol 1986; 1:155-77. 2.Barbieri RL: Hyperandrogenic disorders. Clin Obstet Gynecol 1990; 33:640-54. 3. Atasü T: Kadında androjen metabolizması bozuklukları ve görülen klinik tablolar. İn Atasü T, Şahmay s (eds):Reprodüktif îndokrinoloji. Jinekolojik Endokrinoloji Derneği yayını 1990:277. 4. Speroff L, Glass RH, Kase NG: et al. (eds): Clinical 3ynecologic Endocrinology and Infertility. Baltimore, Williams& A/ilkins 1994:494-8. 5. Esperanza LE, Fenske NA. Hyperandrogenism, insulin resistance, and acanthosis nigricans (HAIR-AN syndrome): spontaneous remission in a 15-year-old girl. J Am Acad Dermatol 1996; 34:892-7. 6. Emler KB, George RM: HAIR-AN syndrome: a multisystem Dhallenge. Am Fam Physician 2001; 15:2385-90. 7.Speiser PW. Congenital adrenal hyperplasia owing to 21-hydroxylase deficiency. Endocrinol Metab Clin North Am 2001;30:31-59. 8.Aziz R, Dewailly D, Owerbach D: Nonclassical adrenal hiperplasia: current concepts J. Clin. Endocrinol. Metab 1994; 78:810. 9.Kütten f, Couillin P, Girard F, et al. Late onset adrenal hyperplasia in hirsutism. N Engl J Med 1985; 313:224-31. 10.Stanic M, Nesovic M. Congenital adrenal hyperplasia. Med Pregl1999;52:447-54. 11.Guess M, Andrew E, Gagliardi C, et al. (eds): Current Obstetric Gynecologic Diagnosis Treatment. Ninth Edition 2003:1001-11. 12. Speroff L, Azziz R, Dunaif A, et al. Diagnosis and management of polycyctic ovary syndrome. Contemporary Obstetrics and Gynecology 1998; 43(suppl):22-5. 13.Carmina E, Lobo RA. Polycystic ovaries in Hirsute women with normal mense. Am J Med 2001; 111:602-6. 14.Barnes RB. Polycystic ovary syndrome and ovarian steroiddogenesis. Seminars in Reproductive Endocrinology 1991; 9:360. 15.Kim Y, Marjoniemi VM, Diamond T, Lim A, Davis G, Murrell D. Androgenetic alopecia in a postmenopausal woman as a result of ovarian hyperthecosis. Australas J Dermatol 2003;44:62-6. Review. 16.Kazerooni T, Dehghan-Kooshkghazi M. Effects of metformin therapy on hyperandrogenism in women with polycystic ovarian syndrome. Gynecol Endocrinol 2003; 17:51-6. 17.Kuntscherova J, Michal M, Novakova R, Jahnova H. Ovarian stromal hyperthecosis,and endometrial carcinoma of the uterus.Ceska Gynekol 2000; 65:94-7. 18.Hock DL, Seifer DB. New treatments of hyperandrogenism and hirsutism. Current Reproductive Endocrinology 2000;27:576-81. 19.Redmond GP: Androjens and Women's healt. Int J Fertil 1998; 43:91. 20.Surrey E