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Journals / Medical Network Klinik Bilimler ve Doktor / 2004 / Cilt: 10 - Sayı: 2

A study of thrombomodulin levels in ERCP

ERCP işleminde serum trombomodulin düzeylerinin araştırılması

Mehmet ASİL
EMİN ALTIPARMAK
Aydın Şeref KÖKSAL
Seyfettin KÖKLÜ
Levent FİLİK
Oğuz ÜSKÜDAR
İbrahim HAZNEDAROĞLU
Burhan ŞAHİN
Pages
131–139
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There is also a need for further studies of the relation between TM levels in acute pancreatitis and other prognostic parameters.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to examine serum thrombomodulin (TM) levels before and after ERCP in patients with cholestasis, with attention to related parameters for the evaluation of post-ERCP activation of endothelium.
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Key Findings & Data:Material and Methods: 30 patients (11 male, 19 female) underging ERCP in our clinic were included in the study.
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Conclusion & Impact:There is also a need for further studies of the relation between TM levels in acute pancreatitis and other prognostic parameters.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kolanjiyopankreatografi · endoskopik retrograd · Pankreatit

Abstract

Objective: The aim of this study was to examine serum thrombomodulin (TM) levels before and after ERCP in patients with cholestasis, with attention to related parameters for the evaluation of post-ERCP activation of endothelium. Material and Methods: 30 patients (11 male, 19 female) underging ERCP in our clinic were included in the study. Patients ages ranged from 22 to 78 years, with an average of 56 13 years. Results: In patients underging ERCP, TM levels were significantly higher after the procedure than before (p 0.05). In patients receving endoscopic sphincterotomy (ES), TM levels levels after ERCP were increased to a statistically significant degree (p 0.05), while in patients not receving ES; levels before and after the procedure were not statistically distinguishable (p 0.05). In patients who had episodes of post- ERCP pancreatitis, post-ERCP serum TM concentrations were significantly higher than before the precedure, while in patients who did not develop pancreatitis, there was no significant difference. In this study, with TM levels being taken in early period of 6 hours after ERCP, high post-ERCP TM concentrations appeared to be predictive of post-ERCP pancreatitis. Conclusion: In order to determine the relation between serum TM concentrations, ERCP and post-ERCP pancreatitis in patients with cholestatic joundice, there is a need for comparison to levels in controlled, prospective and larger studies. There is also a need for further studies of the relation between TM levels in acute pancreatitis and other prognostic parameters.

Özet

Amaç: Bu çalışmada çeşitli nedenlerden ERCP yapılan ve kolestazı olan hastalarda işlem öncesi ve işlem sonrası serum TM düzeylerinin incelenmesi, TM düzeylerinin çeşitli parametrelerle ilişkisinin araştırılması ve ERCP sonrası endotel aktivasyonunun değerlendirilmesi amaçlandı. Gereç ve Yöntem: Kliniğimizde ERCP yapılan 30 hasta çalışma kapsamına alındı. Çalışma grubunu oluşturan 30 hastanın 11'i erkek (%36.7) ve 19'u kadındı (%63.3). Hastaların yaş ortalaması 56±13 yıl (aralık 22-78 yıl) idi. Bulgular:Bu çalışmada ERCP yapılan hastalarda işlem sonrası serum TM düzeylerinin, işlem öncesi düzeylere göre anlamlı derecede yüksek olduğu saptandı (p<0.05). EST yapılan hastalarda ERCP sonrası serum TM düzeylerinde istatistiksel olarak anlamlı artışlar saptanırken (p 0.05), EST yapılmayan hastalarda işlem öncesi ve sonrası değerler arasında fark saptanmadı (p 0.05). Post -ERCP pankreatit gelişen vakalarda ERCP sonrası serum TM konsantrasyonları işlem öncesi değerlerden anlamlı derecede daha yüksek bulunurken, pankreatit gelişmeyen vakalarda aradaki fark anlamlı değildi. Bu çalışmada ERCP'den 6 saat sonra erken dönemde serum TM düzeylerine bakıldığı göz önüne alınırsa, ERCP sonrası yüksek TM konsantrasyonlarının post-ERCP pankreatit gelişimini tahmin etmek açısında prediktif değeri olabilir. Sonuç: Kolestatik sarılığı olan hastalarda serum TM konsantrasyonlarının sağlıklı bireylerle karşılaştırılması, ERCP ve post-ERCP pankreatitle olan ilişkisinin ortaya konabilmesi için daha geniş, kontrollü ve zaman içerisinde TM düzeylerinin takip edildiği prospektif çalışmalara ihtiyaç vardır. Akut pankreatitlerde serum TM düzeylerinin çeşitli prognostik parametrelerle ilişkisini araştıran çalışmalara ihtiyaç vardır.

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Cite This Article

ASİL, M., ALTIPARMAK, E., KÖKSAL, A. Ş., KÖKLÜ, S., FİLİK, L., ÜSKÜDAR, O., HAZNEDAROĞLU, İ., ŞAHİN, B. (2004). A study of thrombomodulin levels in ERCP. Medical Network Klinik Bilimler ve Doktor, Cilt: 10 - Sayı: 2, 131–139. https://ajindex.com/articles/279136

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