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Journals / Medical Network Klinik Bilimler ve Doktor / 2004 / Cilt: 10 - Sayı: 2

Factors affecting weight gain during chemotherapy in breast cancer patients

Meme kanseri olan hastalarda kemoterapi sırasında kilo artışına etki eden faktörler

Can ATALAY
Hüseyin Y. BİRCAN
Lütfi DOĞAN
Mehmet ALTINOK
Pages
158–161
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Without dose adjustment, an increase in local recurrence and a decrease in survival might be expected.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Weight gain has been observed in early stage breast cancer patients during adjuvant chemotherapy.
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Key Findings & Data:Material and Methods: Breast cancer patients treated with adjuvant chemotherapy between May 2002 - May 2003 were evaluated prospectively.
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Conclusion & Impact:Without dose adjustment, an increase in local recurrence and a decrease in survival might be expected.
🔬Design:Research Article
📍Scope:2002 Verileri
⚙️Variables:Kilo artışı · Meme neoplazmları · Doksorubisin

Abstract

Objective: Weight gain has been observed in early stage breast cancer patients during adjuvant chemotherapy. This study aimed to determine the amount of weight gain and the factors affecting weight gain. Material and Methods: Breast cancer patients treated with adjuvant chemotherapy between May 2002 - May 2003 were evaluated prospectively. The patients' weights were measured at the start and after each cycle of chemotherapy. The patients were grouped as those with a weight gain less than and more than 3 kg. These groups and possible factors affecting weight gain were compared in terms of patient and tumor characteristics and chemotherapy applications. Results: 88 patients were included in the study. A significant relation between the amount of weight gain and patient's menopausal status, body-mass index, disease stage, tumor grade, hormonal receptor status, the presence and the number of axillary involvement was not detected. However, weight gain was significantly higher in patients who received 6 cycles compared to 4 cycles of chemotherapy (p=0.002) and treated with doxorubicin compared to epirubicin (p=0.04). In addition, increased food consumption and a decrease in exercise were reported more frequently in patients with weight gain. Conclusion: Adjusting drug doses according to the weight gain during chemotherapy would result in an effective treatment. Without dose adjustment, an increase in local recurrence and a decrease in survival might be expected.

Özet

Amaç: Erken evre meme kanserinde cerrahi sonrası kemoterapi sırasında hastalarda kilo artışı gözlemlenmektedir. Bu çalışmada, gözlemlenen bu kilo artış oranının belirlenmesi ve kilo artışına neden olan faktörlerin saptanması amaçlandı. Gereç ve Yöntem: Kliniğimizde Mayıs 2002-Mayıs 2003 tarihleri arasında cerrahi sonrası kemoterapi uygulanan meme kanserli hastalar prospektif olarak incelendi. Kemoterapinin başlangıcında ve her kür sonrasında hastaların kiloları ölçüldü. Hastalar kilo artışı 3 kg'dan az veya fazla olanlar şeklinde gruplandı. Oluşturulan bu gruplar ve kilo alımına neden olabilecek faktörler hasta ve tümör özellikleri ile kemoterapi uygulamaları açısından karşılaştırıldı. Bulgular: Çalışmaya 88 hasta alındı. Kilo artışının miktarı ile hastanın menapoz durumu, vücut-kütle endeksi, hastalığın evresi, tümörün grade'i, reseptörlerin durumu, aksillada pozitif lenf bezi olması ve bunun sayısı arasında anlamlı bir ilişki saptanmadı. Buna karşın, kilo artışı, 6 kür kemoterapi alanlarda 4 kür alanlara göre (p=0.002) ve doksorubisinli kemoterapi protokolü uygulananlarda epirubisin alanlara göre (p=0.04) anlamlı olarak daha fazla bulundu. Ayrıca, fazla yemek yeme ve egzersiz azlığı da kilo alanlarda daha sık saptandı. Sonuç: Kemoterapi sırasında ilaç dozlarının kilo artışına göre düzenlenmesi ile etkin bir tedavi sağlanabilir. Doz ayarlaması yapılmadığında meme kanseri nüksünde artış ve sağkalımda azalma beklenebilir.

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Cite This Article

ATALAY, C., BİRCAN, H. Y., DOĞAN, L., ALTINOK, M. (2004). Factors affecting weight gain during chemotherapy in breast cancer patients. Medical Network Klinik Bilimler ve Doktor, Cilt: 10 - Sayı: 2, 158–161. https://ajindex.com/articles/279112

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