Type 2 diabetes mellitus and postmenopausal osteoporosis

CONCLUSION: Presence of type 2 diabetes mellitus does not effect the severity of osteoporosis or the efficacy of antiresorptive treatment in postmenopausal osteoporotic patients.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: Although the relation between type 1 diabetes melitus and osteoporosis is well established, the effect of type 2 diabetes mellitus on bone mineral density (BMD) is still controversial.

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Key Findings & Data:This study is performed in order to evaluate the effects of type 2 diabetes mellitus on osteoporosis.

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Conclusion & Impact:CONCLUSION: Presence of type 2 diabetes mellitus does not effect the severity of osteoporosis or the efficacy of antiresorptive treatment in postmenopausal osteoporotic patients.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Postmenopoz · Osteoporoz · postmenopozal

Abstract

AIM: Although the relation between type 1 diabetes melitus and osteoporosis is well established, the effect of type 2 diabetes mellitus on bone mineral density (BMD) is still controversial. This study is performed in order to evaluate the effects of type 2 diabetes mellitus on osteoporosis. MATERIAL AND METHODS: From postmenoposal osteoporotic patients curently on follow-up in the osteoporosis outpatient clinic twenty patients with type 2 diabetes mellitus and 131 age-matched nondiabetic control patients are involved in the study. Both of the groups had received biphosphonate and calcium. Pre- and one year post-treatment bone mineral densities of the lumbar spine are compared within and between the groups. RESULTS: Two groups were similar with regard to age, body mass index, age at menopause and duration of menopause. The difference in bone mineal density values between the diabetic and nondiabetic group was not significant (0.762±0.104 vs 0.768±0.110, respectively; p>0.05). One year antiresorptive treatment resulted in significant increases in spinal BMD in both diabetic (% 5.4, p = 0.007) and nondiabetic (% 6.4, p < 0.001) groups. The change in BMD (ΔBMD) with treatment was not different between the two groups (p = 0.75). CONCLUSION: Presence of type 2 diabetes mellitus does not effect the severity of osteoporosis or the efficacy of antiresorptive treatment in postmenopausal osteoporotic patients.

Özet

AMAÇ: Tip 1 diabetes mellitusun osteoporozla ilişkisi iyi bilinmesine karşın tip 2 diabetes mellitusun kemik mineral yoğunluğuna (KMY) etkileri halen tartışmalıdır. Bu retrospektif çalışmada tip 2 diabetes mellitusun osteoporoz üzerine etkisi olup olmadığını araştırmak amacıyla yapıldı. GEREÇ VE YÖNTEM: Çalışmaya osteoporoz polikliniğinde takip altında olan 20 tip 2 diabetes mellituslu hasta ve bu hastalarla yaşları uyumlu 131 nondiabetik postmenopozal osteoporozlu hasta alındı. Her iki gruptaki hastalara bifosfonat ve kalsiyum tedavisi verilmişti. Grupların tedavi başlangıcı ve tedavinin birinci yılı sonunda kemik mineral yoğunluğu değerleri grup içinde ve gruplar arasında karşılaştırıldı. BULGULAR: Her iki grup yaş, beden kitle indeksi, menopoz yaşı ve menopoz süresi yönünden benzer idi. Tedavi öncesi diabetik grubun spinal KMY değeri ile nondiabetik kontrol grubun KMY değerleri arasındaki fark anlamlı değildi (sırasıyla 0.762±0.104 ve 0.768±0.110, p>0.05). Bir yıllık antirezorptif tedavi sonunda KMY diabetik (% 5.4, p = 0.007) ve nondiabetik (% 6.4, p < 0.001) gruplarda anlamlı artış gösterdi. İki grup arasında tedavi ile oluşan KMY artışları arasındaki fark (ΔKMY) anlamlı bulunmadı (p = 0.75). SONUÇ: Tip 2 diabetes mellitus varlığı postmenopozal osteoporozlu hastalarda osteoporoz ağırlığını ve antirezorptif tedavinin etkinliğini etkilememektedir.

Keywords

Postmenopoz Osteoporoz postmenopozal Menopoz Geriyedönük çalışma Kemik yoğunluğu Diabetes mellitus insülin bağımsız Postmenopause Osteoporosis Postmenopausal Menopause Retrospective Studies Bone Density Diabetes Mellitus Non-Insulin-Dependent

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Cite This Article

GÜLER, S., ODABAŞI, E., ÇAKIR, B., TURAN, M., KUTLU, M., ÖZDEMİR, Ç. (2001). Type 2 diabetes mellitus and postmenopausal osteoporosis. Medical Network Klinik Bilimler ve Doktor, Cilt: 7 - Sayı: 4, 434–436. https://ajindex.com/articles/278828

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