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Journals / Medical Network Klinik Bilimler ve Doktor / 2000 / Cilt: 6 - Sayı: 6

Serum retinol, beta-carotene, zinc, copper, copper / zinc levels in patients with stomach cancer

Mide kanserinde serum retinol, beta-karoten, çinko, bakır, bakır / çinko değerleri

Nesrin UZUNOĞLU
Kadirhan SUNGUROĞLU
Pages
694–699
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: It was concluded that, beta-carotene, Cu, and Cu/Zn ratio may have a diagnostic value with the other diagnostic criteria in gastric cancers.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: We have investigated the correlation of retinol, beta-carotene, zinc (Zn), copper (Cu), Cu/Zn ratio and their variations according to stage and therapy in gastric cancer.
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Key Findings & Data:MATERIAL AND METHOD: The above parameters were analyzed in sera of 67 patients with gastric cancer and 28 healthy controls.
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Conclusion & Impact:CONCLUSION: It was concluded that, beta-carotene, Cu, and Cu/Zn ratio may have a diagnostic value with the other diagnostic criteria in gastric cancers.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Beta karoten · Adenokarsinom · Bakır

Abstract

AIM: We have investigated the correlation of retinol, beta-carotene, zinc (Zn), copper (Cu), Cu/Zn ratio and their variations according to stage and therapy in gastric cancer. MATERIAL AND METHOD: The above parameters were analyzed in sera of 67 patients with gastric cancer and 28 healthy controls. Serum retinol and beta-carotene were determined by spectrophotometric method while Zn and Cu by atomic absorption. RESULTS: Serum beta-carotene values were found to be decreased serum Cu and Cu/Zn ratios were found to be increased in patients when compared to controls. Statistical significancies were p<0.001, p< 0.01, p<0.05 respectively. Pre and post operative evaluation according to stages revealed that Zn and Cu levels were statistically different in stage III (p<0.05). In correlation analysis a significant relation were found between serum Zn and beta-carotene (r:+0.248, p<0.05). CONCLUSION: It was concluded that, beta-carotene, Cu, and Cu/Zn ratio may have a diagnostic value with the other diagnostic criteria in gastric cancers.

Özet

AMAÇ: Mide kanserinde (adenokarsinom) serum retinol, beta-karoten, çinko (Zn), bakır (Cu), Cu/Zn oram arasındaki korelasyonu, evrelere ve tedaviye göre değişimleri inceledik. GEREÇ VE YÖNTEM: 67 mide kanseri hastası ve 28 kontrolde serumda yukarıdaki parametreleri tayin ettik.Serum da retinol ve beta-karoten spektrofotometrik yöntemle, Zn ve Cu'ı atomikabsorbsiyonla tayin ettik. BULGULAR: Serum beta-karoteni düşük, serum Cu ve Cu/Zn oranı değerlerini kontrolden yüksek ve istatistiksel olarak anlamlı bulduk (sırasıyla p<0.001, p<0.0J, p<0.05). Ameliyat olan ve olmayan vakaların evrelere göre incelenmesinde evre IU'de Zn ve Cu'da istatistiksel olarak anlamlı fark bulduk (p<0.05). Korelasyon analizinde serum Zn ve beta-karoten arasında pozitif ilişki tespit ettik (r:+0.248, p<0.05). SONUÇ: Bu çalışmada serum beta-karoten, Cu, Cu/Zn oranı 'nın diğer tanı kriterleri ile birlikte mide kanserinde tanısal bir değeri olabileceği sonucuna varıldı.

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Cite This Article

UZUNOĞLU, N., SUNGUROĞLU, K. (2000). Serum retinol, beta-carotene, zinc, copper, copper / zinc levels in patients with stomach cancer. Medical Network Klinik Bilimler ve Doktor, Cilt: 6 - Sayı: 6, 694–699. https://ajindex.com/articles/278825

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