Journals / Medical Network Klinik Bilimler ve Doktor / 2000 / Cilt: 6 - Sayı: 2

Effect of erythromicine infusion on gallbladder contractility in patients who need total parenteral nutrition

Eritromisin infüzyonunun total parenteral nutrisyon uygulanan hastalarda safra kesesi kontraktilitesi üzerine etkisi

Pages
191–193
DOI
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⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: We conclude that erythromicine infusion should be use as routine prophylaxis against biliary sludge and formation of gallstones in patients receiving long term total parenteral nutrition.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: This study purpose to evaluate the effect of erythromicine on gallbladder contractility in a group of patients who need total parenteral nutrition.
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Key Findings & Data:METHOD: 20 adult patients who need total parenteral nutrition longer than 10 days were evaluated for the study by ultrasonography before and after erythromicine infusion.
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Conclusion & Impact:CONCLUSION: We conclude that erythromicine infusion should be use as routine prophylaxis against biliary sludge and formation of gallstones in patients receiving long term total parenteral nutrition.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kolelitiyaz · Eritromisin · Ultrasonografi

Abstract

OBJECTIVE: This study purpose to evaluate the effect of erythromicine on gallbladder contractility in a group of patients who need total parenteral nutrition. METHOD: 20 adult patients who need total parenteral nutrition longer than 10 days were evaluated for the study by ultrasonography before and after erythromicine infusion. Gallbladder volume studies were performed by obtaining base line ultrasound measurements and than infusing erythromicine over a 10 minute period. Ultrasound measurements of the gallbladder were repeated at 0, 30, 45, 60 and 90 minutes after the initiation of erythromicine infusion. RESULTS: Time releated ultrasonographic findings and statistical reports were indicate the contractil effect of erythromicine on gallbladder. The maximum contractility was detected %82.1 and minimum %23 compared to baseline values. 10(%67) patients were demonstrate maximum contractility at 45 minutes after erythromicine infusion. CONCLUSION: We conclude that erythromicine infusion should be use as routine prophylaxis against biliary sludge and formation of gallstones in patients receiving long term total parenteral nutrition.

Özet

AMAÇ: Bu çalışmanın amacı total parenteral nutrisyon almakta olan hasta grubunda eritromisin İnfüzyonunun safra kesesi kontraktilitesine olan etkisini değerlendirmektir. YÖNTEM: Çalışma için 10 günden fazla süre ile total parenteral nutrisyon almakta olan 20 hasta eritromisin infüzyonu öncesi ve sonrasında ultrasonografi ile değerlendirilmiştir. Safra kesesi volüm çalışmaları ultrasonografik olarak bazal volüm değerleri alındıktan sonra ve eritromisinin 10 dakika süre içinde infüzyonu sonrasında yapılmıştır. Eritromisin infüzyonu sonrasında 0, 30, 45, 60 ve 90. dakikalarda safra kesesi ölçümleri ultrasonografik olarak tekrarlanmıştır. BULGULAR: Zaman bağımlı ultrasonografik bulgular ve istatistik sonuçlan eritromisinin safra kesesi üzerine olan kontraktil etkisini göstermektedir. Bazal değerlerle karşılaştırıldığında maksimum kontraktilite %82. l ve minimum kontraktilite %23 oranında değerlendirilmiştir. 10 (%67) hastada maksimum kontraktilite 45. dakikada izlenmiştir. SONUÇ: Uzun dönem total parenteral nutrisyon alan hastalarda safra çamuru ve taşı oluşumunu önlemede eritromisin İnfüzyonunun rutin proflakside kullanılabileceği görüşündeyiz.

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Cite This Article

BAŞARAN, Ö., DEMİRER, S., KARAYALÇIN, K., ÖZCAN, H., AYDINTUĞ, S. (2000). Effect of erythromicine infusion on gallbladder contractility in patients who need total parenteral nutrition. Medical Network Klinik Bilimler ve Doktor, Cilt: 6 - Sayı: 2, 191–193. https://ajindex.com/articles/278762

References (1)

  1. Sitzmann JV, Pitt HA. Stainborıı PA. Pasha ZR. Sanders RC Cholecystokinin prevents parenteral nutrition induced biliary sludge in humans. Surgery.Gynecology and Obstetrics,1990; 170:25-31. 2.Arienti V, Magri F, Boriani L, Maconi G. Bassein L, Baraldini M. et al. Effect of single dose of oral erythromycin on gastric and gallbladder emptying. Digestive Diseases and Sciences, 1994; 39:1309-1312. 3.Fiorrucci S. Effect of erythromycin on gallbladder emptying in diabetic patients with and without autonomic neuropathy and high levels of motilm Digestive Disease and Sciences, 1992; 37; 1671 -1677. 4.Barr RG, Agnesi.IN, Schaub CR. Acalculous gallbladder disease: US evaluation after slow-infusion cholecystokinin stimulation in symptomatic and asymptomatic adults. Radiology, 1997; 204:105-111. 5.Messing B, Bories C, Kunstlinger F. Bernier JJ. Does total parenteral nutrition induce gallbladder sludge formation and lithiasis? Gastroenterology, 1993; 84:1012-1019. 6.Rosslyn,IJ, Dcnbesten L, Pitt HA, Kuchenbecker S. Polarec JW. Effects of cholecystokinin on gallbladder stasis and cholesterol gallstone formation. Journal of Surgical Research,1981; 30:200-204. 7.Pitt HA, King III W, Mann LI., Roslyn J.I. Berquist WH. Anient ME. et al. Increased risk of cholelithiasis with prolonged total parenteral nutrition American Journal of Surgery, 1983; 145:106-112. 8.Mülller EL, Grace HA, Pitt HA. The effect of parenteral nutrition on biliary calcium and bilirubin. Journal of Surgical Research. 1986: 40:55-62.