Serum immunoglobulin levels in diabetic patients

CONCLUSION: We suggested that higher serum IgA levels might be correlated with diabetic microvascular complications, diabetes duration and glucose regulation.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: In this study we aimed to investigate the relationship between serum immunoglobulins and diabetic complications, glucose regulation diabetes duration and treatment regimens.

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Key Findings & Data:MATERIAL AND METHOD: Fiftysix type II diabetic patients (mean age 54.4±14.4) and 20 non-diabetic patients (mean age 50.1 ± 16.2) were included to the study.

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Conclusion & Impact:CONCLUSION: We suggested that higher serum IgA levels might be correlated with diabetic microvascular complications, diabetes duration and glucose regulation.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Serum globulinleri · Hemoglobin A · glikozillenmiş

Abstract

OBJECTIVE: In this study we aimed to investigate the relationship between serum immunoglobulins and diabetic complications, glucose regulation diabetes duration and treatment regimens. MATERIAL AND METHOD: Fiftysix type II diabetic patients (mean age 54.4±14.4) and 20 non-diabetic patients (mean age 50.1 ± 16.2) were included to the study. Clinical and biochemical parameters of the patients were recorded. Serum immunoglobulin levels were measured. RESULTS: Serum IgA levels of patients with diabetes for more than 5 years were higher significantly than other groups (p<0.05). There was no correlation between serum IgG and IgM levels and diabetes duration. Patients with higher HbA1c-levels (HbA1c> %10) had higher levels of IgA (p<0.05) while IgG and IgM levels did not changed significantly. Patients with diabetic microvascular complications had higher levels of IgA too(p<0.05). Diabetic patients with retinopathy and neuropathy had lower levels of IgG, Serum IgA levels of patients treated with insulin were higher significantly. CONCLUSION: We suggested that higher serum IgA levels might be correlated with diabetic microvascular complications, diabetes duration and glucose regulation.

Özet

AMAÇ: Bu çalışmada, diabetes mellituslu olgularda serum İmmunglobulin düzeyleri ile mikrovasküler komplikasyonlar, glukoz regülasyonu, diabet süresi ve tedavi rejimi arasındaki ilişki araştırıldı. YÖNTEM: 56 Tip II diabetik (yaş ort 54.4±14.4) ve 20 nondiabetik (yaş ort:50.1 ±16.2) çalışmaya alındı. Olguların klinik ve biokimyasal parametreleri kaydedildi. Serum İmmunglobulin düzeyleri ölçüldü. BULGULAR: Diabet süresi 5 yıldan fazla olanlarda Ig A düzeyi kontrol grubu ve diabet süresi 5 yıldan az olanlara göre yüksek bulundu(p %10) IgA düzeyleri diğer olgulara göre anlamlı derecede yüksekti (p<0.05).Glukoz regülasyonu ile IgG ve IgM düzeyleri arasında ilişki bulunmadı. Nefropati, nöropati ve retinopati ile komplike olan diabetiklerde IgA düzeyi anlamlı oranda yüksekti (p<0.05). Retinopatisi ve nöropatisi olan vakalarda IgG düzeyleri düşük saptandı.İnsülin kullanan hastalarda IgA düzeyi kontrol grubuna göre yüksek bulundu. SONUÇ: Bu çalışma diabetiklerde yüksek IgA düzeyi ile diabetik mikrovasküler komplikasyonlar, diabet süresi ve glukoz regülasyonu arasında ilişkinin varlığını düşündürmektedir.

Keywords

Serum globulinleri Hemoglobin A glikozillenmiş Diabetes mellitus Hemoglobinler İmmünoglobulinler Serum Globulins Glycosylated Diabetes Mellitus Hemoglobins Immunoglobulins

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Cite This Article

SERMEZ, Y., KOZDAĞ, G., ORUÇ, N., KALELİ, İ., KESKİN, A., KAPTANOĞLU, B. (2000). Serum immunoglobulin levels in diabetic patients. Medical Network Klinik Bilimler ve Doktor, Cilt: 6 - Sayı: 1, 20–23. https://ajindex.com/articles/278755

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