Prognostic factors in cervical adenocarcinoma

Key Findings & Data:MATERIALS AND METHODS: A retrospective study was performed on 43 patients diagnosed to have adenocarcinoma of the uterine cervix between January 1992 - January 2000.

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Conclusion & Impact:CONCLUSION: Presence of LVSI has a negative effect on the prognosis of cervical adenocarcinoma.

🔬Design:Review & Systematic Survey

📍Scope:2000 Verileri

⚙️Variables:Sağkalım · Sağkalım oranı · Geriyedönük çalışma

Abstract

OBJECTIVE: To determine the prognosis and prognostic factors in cases with adenocarcinoma of the uterine cervix. MATERIALS AND METHODS: A retrospective study was performed on 43 patients diagnosed to have adenocarcinoma of the uterine cervix between January 1992 - January 2000. Medical records were reviewed and crude 5-year survival rate, 5-year disease specific survival rate and 5-year disease free survival rates were calculated via Kaplan-Meier survival analysis. Prognostic factors were evaluated with log-rank test as univariate analysis and Cox regression test as multivariate analysis. RESULTS: The mean age of the patients was 52.8±11.7 (26-76) years. Median follow up period was 35 months. Crude 5-year survival rate, 5-year disease specific survival rate and 5-year disease free survival rates were 80.02%, 84.08% and 64.6%, respectively. Lymphovascular space invasion (LVSI) (p=0.01) and tumor size more than 4 cm (p=0.006) were found to have significant effect on the 5-year disease specific survival rate. Cox regression analysis revealed that presence of LVSI was a poor prognostic factor on the 5-year disease free survival rate (p=0.01, CI= 1.8 - 786). CONCLUSION: Presence of LVSI has a negative effect on the prognosis of cervical adenocarcinoma.

Özet

AMAÇ: Serviks adenokarsinomu (adeno Ca) tanısı alan olgularda prognozu ve prognoza etki eden faktörleri belirlemek. GEREÇ VE YÖNTEM: Ocak 1992-Ocak 2000 tarihleri arasında kliniğimizde serviks adeno Ca tanısı alan ve tedavi edilen 43 hasta retrospektif olarak araştırıldı. Tıbbi kayıtlar gözden geçirildi ve Kaplan- Meier sağ kalım analizi kullanılarak kaba beş yıllık sağ kalım, hastalığa özgü beş yıllık sağ kalım ve beş yıllık hastalıksız yaşam oranları belirlendi. Prognostik faktörlerin incelenmesinde univariate analiz yöntemi olarak log-rank test, multivariate analiz yöntemi olarak Cox regresyon analizi kullanıldı. BULGULAR: Hastaların ortalama yaşının 52.8±11.7 (26-76) olduğu belirlendi. Ortanca takip süresinin 35 ay olduğu bulundu. Kaba beş yıllık sağ kalım, hastalığa özgü beş yıllık sağ kalım ve beş yıllık hastalıksız yaşam oranlarının sırasıyla %80.02, %84.08 ve %64.6 olduğu belirlendi. Log-rank test sonucunda lenfovasküler alan invazyonu (LVSI) pozitifliği (p=0.01) ve tümör çapının 4 cm'den büyük olmasının (p=0.006) hastalığa özgü beş yıllık sağ kalıma etki eden faktörler olduğu belirlendi. Cox regresyon analizi sonucunda sadece LVSI pozitifliğinin beş yıllık hastalıksız sağ kalım için olumsuz bir prognostik faktör olduğu saptandı (p=0.01, CI=1.8-786). SONUÇ: LVSI pozitifliği serviks adeno Ca olgularında prognozu olumsuz yönde etkilemektedir.

Keywords

Sağkalım Sağkalım oranı Geriyedönük çalışma Serviks neoplazmları Adenokarsinom Seyir Survival Survival Rate Retrospective Studies Cervix Neoplasms Adenocarcinoma Prognosis

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Cite This Article

MEYDANLI, M. M., TULUNAY, G., ÇALIŞKAN, E., ÖZGÜL, N., KÖSE, M. F. (2001). Prognostic factors in cervical adenocarcinoma. Medical Network Klinik Bilimler ve Doktor, Cilt: 7 - Sayı: 5, 702–707. https://ajindex.com/articles/278726

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