Changes in serum calcium levels in healthy newborns

These results suggest that calcium regulation during fetal life is related to factors other than PTH and changes in calcium levels are related to PTH during perinatal period.

📌 3 Key Takeaways

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Objective & Hypothesis:Significant alterations in serum calcium concentration occur during the neonatal period.

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Key Findings & Data:Calcium, phosphorus, magnesium and parathyroid hormon (PTH) levels were determined in blood specimens drawn from umblical cord of 48 healthy newborn babies and from the same babies on the second and seventh days after delivery.

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Conclusion & Impact:These results suggest that calcium regulation during fetal life is related to factors other than PTH and changes in calcium levels are related to PTH during perinatal period.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Kalsiyum · Süt çocuğu · yenidoğan

Abstract

Significant alterations in serum calcium concentration occur during the neonatal period. It is important to evaluate these alterations in light of the normal dynamic changes that take place during extrauterine transition. We aimed to determine the changes in calcium concentration during the first week after delivery in healthy term newborns and to investigate the effects of supplementery calcium during pregnancy on calcium regulation of the neonate. Calcium, phosphorus, magnesium and parathyroid hormon (PTH) levels were determined in blood specimens drawn from umblical cord of 48 healthy newborn babies and from the same babies on the second and seventh days after delivery. Two groups were formed. Mothers in the first group had received suplementary calcium during pregnancy and those in the second group had not. Calcium levels on the second day were significantly lower than levels at birth (p< 0.01) and on the seventh day (p< 0.05). Parathyroid hormon levels in cord blood were significantly low compared to those on the second and seventh days (p< 0.001). There was not any significant difference between babies of supplementary calcium receiving and nonreceiving mothers in terms of calcium, phosphorus, magnesium and parathyroid levels. These results suggest that calcium regulation during fetal life is related to factors other than PTH and changes in calcium levels are related to PTH during perinatal period.

Özet

Yenidoğan döneminde serum kalsiyum (Ca) düzeylerinde anlamlı değişiklikler oluşur. Bu değişikliklerin ekstrauterin dönemin başlangıcındaki adaptasyon döneminde ortaya çıkan normal dinamik değişimlerin ışığında değerlendirilmesi önemlidir. Amacımız, zamanında doğan sağlıklı yenidoğanlarda doğumu izleyen ilk hafta içinde Ca konsantrasyonlarındaki değişiklikleri belirlemek ve gebelikte anneye Ca desteği verilmesinin yenidoğan Ca regülasyonu üzerindeki etkilerini araştırmaktır. Bu amaçla zamanında doğan 48 sağlıklı bebeğin kordon, 2. ve 7. günlerdeki kan örneklerinde Ca, fosfor, parathormon (PTH) düzeylerine ve bu bebeklerin annelerinde de doğumdan hemen önce aynı parametrelere bakıldı. Sonuçlar, annelerin Ca desteği alıp almamasına göre 2 gruba ayırarak da değerlendirildi. Bebeklerin kordon kanı Ca düzeylerine göre 2. gün değerlerinin anlamlı olarak düştüğü (p<0.01), 7. günde ise 2. güne göre değerlerin yükseldiği görüldü (p<0.05). Buna karşılık kordon kanı PTH düzeyleri 2. ve 7. gün saptanan düzeylerden anlamlı olarak düşük bulundu (p<0.0001). Ca desteği alan ve almayan annelerin bebeklerinde Ca, fosfor, magnezyum ve PTH düzeyleri açısından anlamlı fark bulunamadı. Bu sonuçlar, kordon kanında PTH düzeylerinin düşük olmasına karşın Ca düzeylerinin normal bulunmasının fetusta Ca regülasyonunun, postnatal dönemin aksine PTH dışındaki faktörlerle ilgili olduğunu düşündürdü.

Keywords

Kalsiyum Süt çocuğu yenidoğan Magnezyum Paratiroid hormonu Fosfor Gebelik Göbek bağı Calcium Infant Newborn Magnesium Parathyroid Hormone Phosphorus Pregnancy Umbilical Cord

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Cite This Article

ERSOY, B., TANSUĞ, N., İNCEBOZ, Ü., KASIRGA, E., ERTAN, P., UYANIK, B. S., ONAĞ, A. (2001). Changes in serum calcium levels in healthy newborns. Medical Network Klinik Bilimler ve Doktor, Cilt: 7 - Sayı: 2, 206–209. https://ajindex.com/articles/278670

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