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Journals / Medical Network Klinik Bilimler ve Doktor / 2001 / Cilt: 7 - Sayı: 1

Investigation of lipid peroxidation and activities of glutathione peroxidase and superoxide dismutase in serum and leukocyte of patients with leukemia

Lösemili hastalarda lipid peroksidasyonu, serum ve lökosit içi glutatyon peroksidaz ve süperoksit dismutaz aktivitelerinin araştırılması

Sinan BAHÇACI
FATİH GÜLTEKİN
İdris AKKUŞ
HÜSAMETTİN VATANSEV
OSMAN ÇAĞLAYAN
Erkan ATAŞ
Pages
79–83
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: Oxidative stress increases in both serum end leukocyte, but no significant changes occur in antioxidant enzymes in patient with leukaemia, and all of these should be considered in the treatment of leukaemia.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: To investigate possible roles of free radicals in leukaemia and to establish activities of antioxidant enzymes.
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Key Findings & Data:MATERIAL AND METHODS: This study was carried out on 17 patients (13 M, 4 F) with leukaemia, aged between 2-21 years and 18 healthy controls (7 M, 11 F) aged between 5-22 years.
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Conclusion & Impact:CONCLUSION: Oxidative stress increases in both serum end leukocyte, but no significant changes occur in antioxidant enzymes in patient with leukaemia, and all of these should be considered in the treatment of leukaemia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Lösemi · Lökositler · Malondialdehit

Abstract

AIM: To investigate possible roles of free radicals in leukaemia and to establish activities of antioxidant enzymes. MATERIAL AND METHODS: This study was carried out on 17 patients (13 M, 4 F) with leukaemia, aged between 2-21 years and 18 healthy controls (7 M, 11 F) aged between 5-22 years. Malondialdehyte (MDA) and d-reactive oxygen metabolites (d-ROM) levels and glutathion peroxidase (GSH-Px) activity were determined in both serum and leukocyte, and SOD activity was determined in leukocyte. RESULTS: Both serum and leukocyte MDA and d-ROM levels were significantly increased in leukaemia group relative to controls (p<0,05). There was no significant difference as to leukocyte SOD and, both serum and leukocyte GSH-Px activities between control and leukaemia groups (p>0,05). CONCLUSION: Oxidative stress increases in both serum end leukocyte, but no significant changes occur in antioxidant enzymes in patient with leukaemia, and all of these should be considered in the treatment of leukaemia.

Özet

AMAÇ: Serbest radikallerin lösemideki rolleri ile antioksidan enzim aktivitelerinin araştırılması. GEREÇ VE YÖNTEM: Bu çalışma, 2-21 yaşları arasında klinik ve laboratuar bulguları ile lösemi teşhisi konmuş 17 hasta (13 erkek, 4 kadın) ile hiç bir klinik şikayeti olmayan 5-22 yaşları arasında 18 sağlıklı kişi (7 erkek, 11 kadın) üzerinde gerçekleştirildi. Hem serum hem de lökosit içi malondialdehit (MDA) ve d-reaktif oksijen metabolitleri (d-ROM) düzeyleri ve glutatyon peroksidaz (GSH-Px) aktivitesi ile lökosit içi süperoksit dismutaz (SOD) aktivitesi tayin edildi. BULGULAR: Hasta grubunda hem serum hem de lökosit içi MDA ve d-ROM düzeylerinin kontrol grubuna göre önemli oranda artmış olduğu bulundu (p 0,05). SONUÇ: Lösemide gerek serum gerekse lökosit içi oksidatif stresin önemli oranda arttığı buna karşılık antioksidan enzim aktivitesinde önemli bir değişiklik olmadığı ve bu durumun tedavide dikkate alınması gerektiği kanaatine varıldı.

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Cite This Article

BAHÇACI, S., GÜLTEKİN, F., AKKUŞ, İ., VATANSEV, H., ÇAĞLAYAN, O., ATAŞ, E. (2001). Investigation of lipid peroxidation and activities of glutathione peroxidase and superoxide dismutase in serum and leukocyte of patients with leukemia. Medical Network Klinik Bilimler ve Doktor, Cilt: 7 - Sayı: 1, 79–83. https://ajindex.com/articles/278658

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