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Journals / Medical Network Klinik Bilimler ve Doktor / 2001 / Cilt: 7 - Sayı: 1

Topical and systemic prophylactic antibiotics in acute appendicitis: Randomized prospective study

Akut apandisitte topikal ve sistemik profilaktik antibiyotik uygulamaları: Karşılaştırmalı prospektif randomize çalışma

A. Haldun ÖZCAN
Turgut ÇAVUŞOĞLU
Haluk TÜMER
Alper DOĞU
M. Reha ÖZGÜVEN
Mehmet PETEK
Savaş TEZEL
Pages
59–61
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: It has been shown that preincisional sufficient tissue saturation is more important than the application way of the antibiotics.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: This study was designed to compare the use of topical and systemic prophytactic antibiotics in acute appendicitis.
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Key Findings & Data:MATERIAL AND METHODS: 163 patients operated because of acute appendicitis between November 1998-January 2000 in 3.
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Conclusion & Impact:CONCLUSION: It has been shown that preincisional sufficient tissue saturation is more important than the application way of the antibiotics.
🔬Design:Research Article
📍Scope:2000 Verileri
⚙️Variables:Ameliyat sonrası dönem · Apandisit · Antibiyotik proflaksisi

Abstract

AIM: This study was designed to compare the use of topical and systemic prophytactic antibiotics in acute appendicitis. MATERIAL AND METHODS: 163 patients operated because of acute appendicitis between November 1998-January 2000 in 3. Department of General Surgery, were randomized as preincisional metronidazole and iv cefazolin(Group A), iv metronidazole and iv cefazolin(Group B), preincisional cefoxitine(Group C) and iv cefoxitine(Group D). The patients were evaluated for the postoperative infection signs and discharge. RESULTS: Postoperative infection was detected at 1 patient for each groups of iv metronidazole and iv cefazolin(Group B), preincisional cefoxitine(Group C) and iv cefoxitine(Group D). E.Coli was isolated in all wound cultures. There was no significant difference between the groups for infection .(p>0.05). The use of single or combined anti-aerob and anti-anaerob antibiotics maintains effective prophylaxis at prevention of post-appendectomy sepsis. CONCLUSION: It has been shown that preincisional sufficient tissue saturation is more important than the application way of the antibiotics.

Özet

AMAÇ: Bu çalışmada akut apandisitte topikal ve sistemik profilaktik antibiyotik kullanımının karşılaştırılması planlanmıştır. GEREÇ VE YÖNTEM: Kasım 1998 ile Ocak 2000 tarihleri arasında, 3. Genel Cerrahi Kliniğinde akut apandisit nedeniyle opere edilen 163 hasta, preinsizyonel metronidazol ve intravenöz cefazolin (Grup A), intravenöz metronidazol ve intravenöz cefazolin (Grup B), preinsizyonel cefoxitin (Grup C), intravenöz cefoxitin (Grup D) gruplarına randomize olarak alındı. Postoperatif dönemde hastalar enfeksiyon bulguları ve pürülan akıntı yönünden değerlendirildi. BULGULAR: Postoperatif dönemde intravenöz metronidazol ve intravenöz cefazolin (Grup B), preinsizyonel cefoksitin (Grup C), intravenöz cefoksitin (Grup D) gruplarında birer hastada enfeksiyon gözlendi. Alınan kültürlerin tümünde E.coli üredi. Gruplar arasında enfeksiyon oluşumu açısından anlamlı fark gözlenmedi (p>0.05). Postappendektomi sepsisin önlenmesinde, aeorob ve anaerob organizmalara etkili tek ya da kombine antibiyotiklerin preoperatif uygulanması etkin bir proflaksi sağlamaktadır. SONUÇ: Antibiyotiğin veriliş yolundan çok insizyon öncesinde yeterli doku düzeyi oluşacak şekilde uygulanması yeterli gibi görünmektedir.

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Cite This Article

ÖZCAN, A. H., ÇAVUŞOĞLU, T., TÜMER, H., DOĞU, A., ÖZGÜVEN, M. R., PETEK, M., TEZEL, S. (2001). Topical and systemic prophylactic antibiotics in acute appendicitis: Randomized prospective study. Medical Network Klinik Bilimler ve Doktor, Cilt: 7 - Sayı: 1, 59–61. https://ajindex.com/articles/278657

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