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Journals / Medical Network Klinik Bilimler ve Doktor / 2002 / Cilt: 8 - Sayı: 6

Gastric emptying time in type I and type II diabetes mellitus

Tip I ve tip II diabetes mellituslu hastalarda mide boşalma zamanı

Hamiyet YILMAZ
Funda CERAN
Nevzat ILIMAN
Düzgün ÖZATLI
Alp BOYDAK
Aslı TUNCER
Mehmet YILDIZ
Pages
691–694
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, diabetic patients with gastroparesis should be examined for autonomic neuropathy and glycaemic control.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: In this study, evaluation of gastric emptying time in type I and type II diabetic patients was aimed.
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Key Findings & Data:MATERIAL AND METHOD: Gastric emptying of a digestible solid and liquid meal were measured with scintigraphic techniques in type I and II diabetic and control groups which each contain 25 subjects.
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Conclusion & Impact:Therefore, diabetic patients with gastroparesis should be examined for autonomic neuropathy and glycaemic control.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Diabetes mellitus · insülin bağımlı · Diabetes mellitus

Abstract

OBJECTIVE: In this study, evaluation of gastric emptying time in type I and type II diabetic patients was aimed. MATERIAL AND METHOD: Gastric emptying of a digestible solid and liquid meal were measured with scintigraphic techniques in type I and II diabetic and control groups which each contain 25 subjects. In the diabetic patients, the relationships between gastric emptying and age, sex, glycaemic control, autonomic nerve function, microalbuminuria and upper gastrointestinal symptom score were examined. RESULTS: Gastric emtying time (for solid or liquid meal or both) was delayed in 60% of type I and 52% of type II diabetic patients. In type I and type II diabetic patients, there were no significant correlations between gastric emptying time and upper gastrointestinal symptom score, age, sex, disease duration, microalbuminuria and fasting blood glucose levels. In type I diabetic patients, gastric emptying time for solid and liquid meal was positively related to autonomic neuropathy. In type II diabetic patients, while there was a positive correlation between gastric emptying time for liquid meal and autonomic neuropathy and HbA1C, there was no correlation between gastric emptying time for solid meal and any parameter studied. CONCLUSION: Diabetic gastroparesis on a large scale can be explained by autonomic neuropathy. But also, hyperglycaemia itself may be responsible for delayed gastric emptying. Therefore, diabetic patients with gastroparesis should be examined for autonomic neuropathy and glycaemic control.

Özet

AMAÇ: Tip I ve tip II diabetes mellituslu (DM) hastalarda mide boşalma zamanının incelenmesi amaçlandı. GEREÇ VE YÖNTEM: 25'er kişiden oluşan tip I ve tip II DM'li hasta ve kontrol gruplarında katı ve sıvı gıdalar için mide boşalma zamanı sintigrafik teknik ile ölçüldü. DM'li hastalarda mide boşalma zamanı ile DM süresi, yaş, cinsiyet, glisemik kontrol, mikroalbuminüri, üst gastrointestinal semptom skoru ve otonom nöropati arasındaki ilişkiler incelendi. BULGULAR: Tip I DM'li grupta %60 hastada, tip II DM'li grupta %52 hastada mide boşalma zamanı (katı veya sıvı gıdalar ya da her ikisi içinde) uzamış olarak tespit edildi. Tip I ve tip II DM'de, mide boşalma zamanı ile üst gastrointestinal semptom skoru, yaş, cinsiyet, DM süresi, mikroalbuminüri ve açlık kan şekeri arasında anlamlı korelasyon yoktu. Tip I DM'de katı ve sıvı faz mide boşalma zamanı ile otonom nöropati arasında pozitif korelasyon vardı. Tip II DM'de ise, sıvı faz mide boşalma zamanı ile HbA1C ve otonom nöropati arasında pozitif korelasyon varken, katı faz mide boşalma zamanı ile çalışılan herhangi bir parametre arasında korelasyon yoktu. SONUÇ: DM'li hastalarda görülen gastroparezi, büyük ölçüde otonom nöropati ile açıklanabilir. Ancak hipergliseminin kendisi de gastropareziye neden olabilir. Bu nedenle DM'li gastroparezisi olan hastalar, otonom nöropati ve glisemik kontrol açısından incelenmelidirler.

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Cite This Article

YILMAZ, H., CERAN, F., ILIMAN, N., ÖZATLI, D., BOYDAK, A., TUNCER, A., YILDIZ, M. (2002). Gastric emptying time in type I and type II diabetes mellitus. Medical Network Klinik Bilimler ve Doktor, Cilt: 8 - Sayı: 6, 691–694. https://ajindex.com/articles/278606

References (16)

  1. Horowitz M, Harding PE, Maddox A, Wishart JM, Akkermans L-M, Chatterton BE. Gastric and oesophageal emptying in patients with type II diabetes mellitus. Diabetologia 1989; 32:151-9.
  2. Buysschaert M, Moulart M, Urbain CL, et al. impaired gastric emptying in diabetic patients with cardiac autonomic neuropathy. Diabetes Care 1987; 10:448-52.
  3. Merio R, Festa A, Bergmann H, et al. Slow gastric emptying in type I diabetes: relation to autonomic and peripheral neuropathy, blood glucose and glycaemic control. Diabetes Care 1997; 20:419-23.
  4. Keshavarzian A, Iber FL, Vaeth J. Gastric emptying in patients with insulin- requiring diabetes mellitus. Am.J.Gastroenterology 1987; 82:29-35.
  5. Fraser RJ, Horowitz M, Maddox A, Harding PE, Chatterton BE, Dent J, Hyperglycaemia slows gastric emptying in type I diabetes mellitus. Diabetologia 1990; 33:675-80.
  6. Samsom M, Akkermans LM, Jebbink RJ, Isselt H, Henegouwen B, Smount AJ. Gastrointestinal motor mechanisms in hyperglycaemia induced delayed gastric emptying in type I diabetes mellitus. Gut 1997; 40:641-6.
  7. Lyrenas EB, Olsson EH, Arvidsson UC, Orn TJ, Spjuth JH. Prevalence and determinants of solid and liquid gastric emptying in unstable type I diabetes. Relationship to postprandial blood glucose concentrations. Diabetes Care 1997; 20:413-8.
  8. Schade D, Drumm D, Duckworth W, Eaton PL. The etiology of incapacitating, brittle diabetes. Diabetes Care 1985; 8:12-20.
  9. Kong MF, Horowitz M, Jones K, Wishart JM, Harding PE. Natural history of diabetic gastroparesis. Diabetes Care 1999; 22:503-7.
  10. Ewing DJ, Clarke BF. Diagnosis and management of diabetic autonomic neuropathy. British medical journal 1982; 285:916-8.
  11. Houghton LA, Read NW, Heddle R, et al. Relationship of the motor activity of the antrum, pylorus, and duodenum to gastric mtying of a solid-liquid mixed meal. Gastroenterology 1988; 94:1285-91.
  12. Mearin F, Camilleri M, Malagelada JR. Pyloric dysfunction in diabetics with recurrent nausea and vomiting. Gastroenterology 1986; 90:1919-25.
  13. Fraser R, Horowitz M, Dent J. Hyperglycaemia stimulates pyloric motility in normal subjects. Gut 1991; 32:475-8.
  14. Güvener N, Akçan Y, Paksoy I, et al. Helicobacter pylori associated gastric pathology in patients with type II diabetes mellitus and its relationship with gastric emptying: the Ankara study. Exp Clin Endocrin Diabet 1999; 107:172-6.
  15. Brown CK, Khanderia U. Use of metoclopramide, domperidone, and cisapride in the management of diabetic gastroparesis. Clin Pharm 1990; 9:357-65.
  16. Frazee LA, Mauro