AI Summary & Key Takeaways
AI InsightThere were multiply cysts in 57 cases and according to the results of amniotic all cultures, normal karyotype was found in 82 cases.
📌 3 Key Takeaways
Abstract
Objective: Chromosomal defects were evaluated in amniotic cell cultures that were made for choroid plexus cysts. Materials and Methods: Amniocenthesis was made to patients that choroid plexus cysts over 4 mm were determined in rutine ultrasonography. Results: The average age of 84 cases with choroid plexus cyst determined in routine obstetric researches was 26.1 (18-37). Twelve of these patients were over 35 years old. The average of gravidity was 2, parity was 1. None of these patients had maternal systemic diseases and story of using drugs or having x-ray. There was relationship between couples in first degree only in one case and in three couples there were third degree relationship. The average ultrasonographic gestational age was 19 weeks 6 days. And any other anomalies weren't determined. When plexus cysts were evaluated, 65 cases were smaller than 8 mm and 19 cases were bigger than 8 mm. In 51 cases the cysts were bilateral. There were multiply cysts in 57 cases and according to the results of amniotic all cultures, normal karyotype was found in 82 cases. In one case reciprocal translocation, also in one case trisomy 18 (Edward's Syndrome) was determined. Conclusion: Choroid plexus cysts may be seen together with fetal chomosomal anamolies. Because of this purpose; chromosomal researches with amniocenthesis is must be offered when choroid plexus cysts are determined.
Özet
Amaç: Koroid pleksus kisti nedeniyle yapılan amniotik hücre kültürlerinde saptanan kromozom bozuklukları değerlendirildi. Gereç ve Yöntem: Rutin ultrasonografik incelemelerde 4 mm üzerinde koroid pleksus kisti saptanan olgulara amniosentez yapıldı. Amniotik hücre kültürlerinde saptanan kromozom bozuklukları değerlendirildi. Bulgular: Rutin obstetrik taramalarda koroid pleksus kisti tespit edilen 84 olgunun yaş ortalaması 26.1 (18-37) idi. 12 olgu 35 yaşın üzerindeydi. Olguların gravida ortalaması 2 parite ortalaması 1 idi. Hiçbir olguda belirgin ciddi maternal hastalık, gebelikte ilaç kullanımı veya x-ray ile karşılaşma öyküsü bulunmamaktaydı. Bir olguda 1. dereceden, 3 olguda 3. dereceden akraba evliliği tespit edildi. Fetüslerin ultrasonografik olarak ortalama gebelik yaşları 19 hafta 6 gündü ve hiçbirinde başkaca anomali tespit edilmedi. Koroid pleksus kistleri değerlendirildiğinde; 65 olguda (%77.3) 8 mm den küçük, 19 olguda ise (%22.7) 8 mm üzerinde kistler tespit edildi. 51 olguda (%60.7) kistler bilateraldi. 57 olguda (%67.8) multıpl kistler mevcuttu. Amniotik hücre kültürü sonuçlarında 82 olguda normal karyotip saptandı. Bir olguda resiprokal translokasyon, bir olguda da trizomi 18 (Edward's sendromu) tespit edildi. Sonuç: Koroid pleksus kistleri fetal kromozomal anomalilere eşlik edebilir. Bu nedenle tespit edildiğinde amniosentez ile kromozom tayinleri önerilmelidir.