Journals / Medical Network Klinik Bilimler ve Doktor / 2002 / Cilt: 8 - Sayı: 5

Epidemiology and risk factors in gestational trophoblastic disease

Gestasyonel trofoblastik hastalıklarda epidemiyoloji ve risk faktörleri

Pages
636–641
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: In this study it was found that the prevalence of GTH was higher when it compared with Far East countries and lower with west countries.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:OBJECTIVE: An epidemiological study and possible risk factors were evaluated for 165 gestational trophoblastic disease (GTD).
📊
Key Findings & Data:MATERIALS AND METHODS: This study was conducted at the Oncology Department of Zekai Tahir Burak Woman Health Education and Research Hospital in between 1996-1999.
💡
Conclusion & Impact:CONCLUSION: In this study it was found that the prevalence of GTH was higher when it compared with Far East countries and lower with west countries.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Risk faktörleri · Epidemiyolojik çalışmalar · Epidemiyolojik faktörler

Abstract

OBJECTIVE: An epidemiological study and possible risk factors were evaluated for 165 gestational trophoblastic disease (GTD). MATERIALS AND METHODS: This study was conducted at the Oncology Department of Zekai Tahir Burak Woman Health Education and Research Hospital in between 1996-1999. RESULTS: Out of 165 cases, 100 was diagnosed as hydatidiform mole, 45 was diagnosed as invasive hydatidiform mole and 20 was diagnosed as choriocarcinoma. The prevalence of GTD and choriocarcinoma was found 1.78 and 0.21 in 1000 birth respectively. In the respect of ages there was a significant importance between the groups(P<0.05). Even though the distribution of the gravidity was similar in the groups; The cases of primigravids were mostly seen in mole hydatidiform cases. The socioeconomic level between the groups were similar but most of the cases of GTD were from low or moderate socioeconomic level. On the other hand A Rh (+) was the most frequent blood type which was detected in the study group. CONCLUSION: In this study it was found that the prevalence of GTH was higher when it compared with Far East countries and lower with west countries. It was also concluded that having low or moderate socioeconomic level, a history of mole hydatidiform and A Rh (+) blood type could be a possible risk factors for GTD.

Özet

AMAÇ: Gestasyonel Trofoblastik Hastalık (GTH) tanısı almış olan 165 hasta'nın epidemiyolojik ve olası risk faktörleri açısından değerlendirilmesi. GEREÇ VE YÖNTEM: Bu retrospektif çalışma, Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi Onkoloji Kliniğinde 1996-1999 yılları arasında gerçekleştirildi. BULGULAR: 165 olgunun 100'ü mol hidatidiform,geriye kalan 65 hastanın 45'i invasive mol ve 20'si koryokarsinom tanısı almıştı. GTH sıklığını 1000 doğumda 1.78, koryokarsinom sıklığını 1000 doğumda 0.21 olarak saptadık. Gruplar yaş dağılımı açısından irdelendiğinde, her üç gruptaki hastaların yaş dağılımları arasında anlamlı bir farklılık mevcuttu(p<0.05). Her üç gruptaki gravida yönünden dağılım, birbirine benzemekle beraber mol hidatidiform olgularının primigravidlerdeki sıklığı dikkat çekiciydi. Gruplar arasında sosyoekonomik düzey dağılımı benzerlik gösterir iken olguların büyük bir kısmının orta ve kötü sosyoekonomik düzeye sahip olduğu, yine olguların büyük bir kısmında A Rh (+) kan grubu sıklığı dikkat çeken başka bir özellik olarak karşımıza çıkmaktaydı. SONUÇ: Çalışmamızda GTH prevelansını, uzak doğu ülkelerine yakın buna karşın batı ülkelerine göre yüksek bir değer olarak saptadık. GTH oluşumunda kötü ve orta sosyoekonomik düzey, geçirilmiş mol hidatidiform öyküsü ve ARh (+) kan grubunun birer risk faktörü olabileceğini sonucuna ulaştık.

🔖

Cite This Article

OĞUZ, S., AĞIRTAŞ, A., AYDOĞDU, T., GÜNYELİ, İ., KÜÇÜKOZAN, T. (2002). Epidemiology and risk factors in gestational trophoblastic disease. Medical Network Klinik Bilimler ve Doktor, Cilt: 8 - Sayı: 5, 636–641. https://ajindex.com/articles/278568

References (2)

  1. Berkowitz RS, Goldenstein DP. The management of molar pregnancy and gestational trophoblastic tumors. In: Knapp RC, Berkowitz RS, eds. Gynecologic Oncology. 2nd ed. New York: Me Graw-Hill, 1993; 328-38. Bagshawe KD. Risks and prognostic factors in trophoblastic neoplasia Cancer, 1976; 38:1373-85. Hammond CB. Gestational trophoblastic neoplasms: History of the current understanding. Obstet Gynecol Clin North Am, 1988; 15:435. Mungan T, Kuscu E, Dabakoglu T, Senoz S, Ugur M, Cobanoglu O. Hydatiform mole: clinical analysis of 310 patients. Int J Gynecol Obstet, 1996; 52:233-6.
  2. Hsu CT, Jang HL, Wang TT, et al. Recent changes in the epidemiology of GTN in Taiwan, Roc: Preliminary report. Asia-Oceania. J Obstet Gynecol, 1988; 14: 61. Messerli ML, Lilienfeld AM, Parmley T, et al. Risk factors for gestational troqhoblastic neoplasia. Am J Obstet Gynecol, 1985; 153-294. Grimes DA. Epidemiology of gestational trophoblastic disease. Am J Obstet Gynecol, 1984; 150:309-18. NowakMarkwitz E,Drews K,Spaczynski M.Gestational trophoblastic disease:the epidemiological analysis of 342 cases.Gineko Pol 2000; 71:767- 72. Kim SJ, Bae SN, Kim JH, Kim CH, Han KT, Chung JK, Lee JM. Epidemiology and time trends of gestational trophoblastic disease in Korea.Int J Gynaecol Obstet 1998; 60:S33-8. (Suppl 1) 10.La Vecchia C, Franceshi S, Parazzini F, et al. Risk factors for gestational trophoblastic disease in Italy. Am J Epidemiol, 1985; 121:457. 11.Parazzini F, La Vecchia, Franceschi S, et al. ABO blood groups and the risk of gestational trophoblastic disease. Tumor, 1985; 71:123. 12.Palmer JR. Advances in the epidemiology of gestational trophoblastic disease. J Repred Med, 1994; 39:155-62. 13.Zanetha G, Maggi R, Colombo M, et al. Choriocarcinoma coexistent with intrauterine pregnancy: Two additional cases and review of the literature. Int J Gynecol Cancer, 1997; 7:66. 14.Ayhan A, Yapar EG, Deren Ö, et al. Remission rates and significance prognostic factors in gestational trophoblastic tumors. J Repred Med, 1992; 37:461. 15.Zalel Y, Dgani R. Gestational trophoblastic disease following the evacuation of partial hydatidiform mole: a review of 66 cases. Eur J Obstet Gynecol ReprodBiol, 1997; 71:67-71. 16.Grimes DA. Epidemiology of gestational trophoblastic disease. Am J Obstet Gynecol, 1984; 150:309-18. 17.Martin PM. High frequency of hydatidiform mole in Alaskans. Int J Gynaecol Obstet, 1978; 15:395. 18.Kim SJ, Bae SN, Kim CJ, Han KT, Chung JK, Lee JM. Epidemiology and time trends of