Journals / Medical Network Klinik Bilimler ve Doktor / 2004 / Cilt: 10 - Sayı: 4

Brown tumors associated with primary hyperparathyroidism simulating metastatic disease

Metastatik hastalığı taklit eden primer hiperparatiroidiye bağlı Brown tümörü

Pages
418–422
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Although bone lesions due to primary hyperparathyroidism are rarely seen recently, they must be suspected in the differential diagnosis of the patients with bone pain and multiple osteolitic lesions.

📌 3 Key Takeaways

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Objective & Hypothesis:Brown tumor is a term used to designate the end-stage bone disease associated with primary or secondary hyperparathyroidism.
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Key Findings & Data:In hyperparathyroidism, due to increased osteoclastic activity, bone resorption and cystic changes are observed.
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Conclusion & Impact:Although bone lesions due to primary hyperparathyroidism are rarely seen recently, they must be suspected in the differential diagnosis of the patients with bone pain and multiple osteolitic lesions.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hiperparatiroidi · primer · Hiperkalsemi

Abstract

Brown tumor is a term used to designate the end-stage bone disease associated with primary or secondary hyperparathyroidism. In hyperparathyroidism, due to increased osteoclastic activity, bone resorption and cystic changes are observed. Primary hyperparathyroidism is usually diagnosed following the incidental finding of hypercalcemia in biochemistry tests. Here, three female patients presenting with leg pain and inability to walk were admitted to the hospital with the diagnosis of primary or metastatic bone tumor and parathyroidectomy was performed due to an adenoma. Patients became asymptomatic after surgery. Although bone lesions due to primary hyperparathyroidism are rarely seen recently, they must be suspected in the differential diagnosis of the patients with bone pain and multiple osteolitic lesions.

Özet

Brown tümörü, primer veya sekonder hiperparatiroidiye bağlı gelişen kemik lezyonlarının son dönemdeki haline verilen isimdir. Hiperparatiroidide osteoklastik aktivite artışına bağlı olarak kemiklerde rezorpsiyon ve kistik değişiklikler görülür. Primer hiperparatiroidi tanısı günümüzde rutin biyokimya incelemeleri sırasında rastlantısal olarak saptanan hiperkalsemi ile konulmaktadır. Bacak ağrısı ve yürüyememe şikayetleri ile başvuran üç kadın hasta primer kemik tümörü veya multipl kemik metastazı tanısı ile hastaneye yatırılmış ve tetkikler sonucunda paratiroid adenomu saptanarak paratiroidektomi uygulanmıştır. Cerrahi sonrası hastaların semptomları düzelmiştir. Günümüzde primer hiperparatiroidiye bağlı kemik lezyonlarına sık rastlanmasa da kemik ağrıları ve multipl osteolitik lezyonu bulunan hastalarda ayırıcı tanıda düşünülmelidir.

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Cite This Article

KURUKAHVECİOĞLU, O., ATALAY, C., HÜSEYİNOVA, S., ALTINOK, M. (2004). Brown tumors associated with primary hyperparathyroidism simulating metastatic disease. Medical Network Klinik Bilimler ve Doktor, Cilt: 10 - Sayı: 4, 418–422. https://ajindex.com/articles/278444

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