Adhesion molecules (VCAM-1 and ICAM-1) in preeclampsia

Objective & Hypothesis:Objective: To investigate the circulating levels of adhesion molecules (VCAM-I, ICAM-I) as the markers for activation of the immune system, emphasize the existence of endothelial damage and the role of adhesion molecules in preeclamptic patients.

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Key Findings & Data:Material and Methods: 47 patients with preeclampsia and eclampsia were compared to 42 healthy pregnant women.

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Conclusion & Impact:These results may indicate the immune activation in the pathophysiologic mechanisms of preeclampsia.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Hücre içi adezyon molekülü-1 · Enzim bağlı immünosorbent tayini · Preeklampsi

Abstract

Objective: To investigate the circulating levels of adhesion molecules (VCAM-I, ICAM-I) as the markers for activation of the immune system, emphasize the existence of endothelial damage and the role of adhesion molecules in preeclamptic patients. Material and Methods: 47 patients with preeclampsia and eclampsia were compared to 42 healthy pregnant women. Peripheral venous blood samples were obtained and serum levels of VCAM-I, ICAM-I were measured by using enzyme-linked immunoassay (ELISA). Results: Concentrations of VCAM-I and ICAM-I were significantly higher (p<0.0005) in preeclamptic women compared to healthy pregnant patients. The results were similar when the patients were clinically grouped as mild and severe preeclampsia. Conclusions: Increased circulating levels of adhesion molecules (VCAM-I and ICAM-I) may contribute to the endothelial damage that occurs with preeclampsia and eclampsia. This increment does not correlate with the severity of the disease. These results may indicate the immune activation in the pathophysiologic mechanisms of preeclampsia.

Özet

Amaç: Preeklampsideki endotel hasarı ve immün aktivasyonunun belirteci olarak dolaşımdaki adhezyon moleküllerinin (VCAM-1 ve ICAM-1) varlığını araştırmak ve hastalığın derecesi ile bağlantısına karar vermek. Gereç ve Yöntem: Preeklampsi ve eklampsi tanısı konan 47 hasta , aynı gebelik haftalarında 42 sağlıklı gebe ile karşılaştırıldı. Periferik kan örnekleri alındı ve serum VCAM-1 ve ICAM-1 seviyeleri ELISA enzyme-linked immunoassay) yöntemi kullanılarak ölçüldü. Bulgular: VCAM-1 ve ICAM-1 seviyeleri preeklamptik hasta grubunda belirgin olarak yüksek bulundu (p‹0.0005). Hasta grup preeklampsinin derecesine göre hafif ve ağır olarak ayrıldığında sonuçlarda farklılık tespit edilmedi. Sonuç: Adhezyon molekülleri (VCAM-1 ve ICAM-1) preeklampside oluşan endotel hasarına bağlı olarak dolaşımda artar. Bu artış hastalığın derecesine bağlı olmayıp preeklampsinin etiyopatogenezinde etkili olan immün aktivasyona bağlıdır.

Keywords

Hücre içi adezyon molekülü-1 Enzim bağlı immünosorbent tayini Preeklampsi Hücre adezyon molekülleri Vasküler hücre adezyon molekülü-1 ELISA Intercellular Adhesion Molecule-1 Enzyme-Linked Immunosorbent Assay Pre-Eclampsia Cell Adhesion Molecules Vascular Cell Adhesion Molecule-1

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Cite This Article

ÇAM, Ç., ÇAM, M., TURAN, C., KARATEKE, A., ALTINOK, T. (2005). Adhesion molecules (VCAM-1 and ICAM-1) in preeclampsia. Medical Network Klinik Bilimler ve Doktor, Cilt: 11 - Sayı: 1, 74–76. https://ajindex.com/articles/278393

References (9)

Roberts JM. Pregnancy related hypertension. In. Creasy RK, Resnik R, eds. Maternal-fetal medicine: prnciples and practice, 2nd ed. Philadelphia: Saunders, 1989:777-823
Harlan JD. Neutrophil-mediated vascular injury. Acta Med Scand 1987; 75:123-9
Gearing AJH, Newman W. Circulating adhesion molecules in disease. Immunol Today 1993; 14:506-12
Greer IA, Dawes J, Johnston TA, Calder AA. Neutrophil activation is confined to the maternal circulation in pregnancy-induced hypertension. Obstet Gynecol 1991; 78:28-32
Lyall F, Greer IA, Boswell F, Macara LM, Wlker JJ, Kingdom JC. The adhesion molecule VCAM-I is selectively elevated in the serum in preeclampsia. Br J Obstet Gynecol 1994; 101:485-7
Krauss T, Kuhn W, Lakoma C, Hellmut GA. Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk for development of preeclampsia. Am J Obstet Gynecol 1997; 177:443-9
Krauss T, Emons G, Kuhn W, Augustin HG. Predictive value of routinecirculating soluble endothelial cell adhesion molecule measurements during pregnancy. Clin Chem 2002; 48:5418-25
Budak E,.Madazlı R, Aksu MF, et al. Vascular cell adhesior molecule-l and leucocyte activation in preeclampsia and eclampsia. Int J Gyn and Obstet 1998; 63:115-21
Coata G, Pennacchi L, Bini V, Liotta L, Di Renzo GC J Matem Fetal Neonatal Med. 2002; 12:28-34.