Journals / Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi / 2020 / Cilt: 10 - Sayı: 2

Total Fenolic Contents of Ferula elaeochytris Root Extract and Its Effect on Glucose Levels

Ferula elaeochytris Kök Ekstresinin Toplam Fenolik Bileşikler ve Glukoz Seviyesi Üzerine Etkisi

Pages
154–161
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It can be concluded that Ferula elaeochytris may have a hypoglycemic effect owing to its inhibitory effect on glucose levels and Ferula elaeochytris may also have a possible antioxidant source by means of the plant has a high capacity of total phenolic content.

📌 3 Key Takeaways

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Objective & Hypothesis:Nowadays, diabetes is a metabolic disease characterized by hyperglycemia by a problem in insulin secretion, insulin action, or both.
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Key Findings & Data:In this study, according to electrochemical analysis with biosensor device, a linear decrease in glucose levels was observed depends on the decrease of enzyme-substrate interaction as a result of the addition of 100 µl cumulatively 1 minute (min) intervals of Ferula elaeochytris root extract (N=120).
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Conclusion & Impact:It can be concluded that Ferula elaeochytris may have a hypoglycemic effect owing to its inhibitory effect on glucose levels and Ferula elaeochytris may also have a possible antioxidant source by means of the plant has a high capacity of total phenolic content.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Ferula elaeochytris · biyosensör · fenolik bileşikler

Abstract

Nowadays, diabetes is a metabolic disease characterized by hyperglycemia by a problem in insulin secretion, insulin action, or both. It is known that oxidative damage plays an important role in the development of vascular and neurogenic complications of diabetes and antioxidants are effective on these pathologies. The aim of this study was to investigate the possible antidiabetic and antioxidant effects of Ferula elaeochytris root extract, commonly known as “ÇAKŞIR” in South and Southeastern Anatolia. Ferula elaeochytris was collected from the Engizek plateau of Kahramanmaraş. The plant root was prepared on a clean and dry surface and ground for grinding. The inhibitory effect of Ferula eleaochytris on glucose was determined electrochemically with the biosensor device, and total phenolic content was determined by Folin-Ciocalteu method as an indicator of antioxidant activity. In this study, according to electrochemical analysis with biosensor device, a linear decrease in glucose levels was observed depends on the decrease of enzyme-substrate interaction as a result of the addition of 100 µl cumulatively 1 minute (min) intervals of Ferula elaeochytris root extract (N=120). In addition, the total phenolic content of this plant was detected (41.45±2.38 mg GAE/g, n:3) by Folin-Ciocalteu method. It can be concluded that Ferula elaeochytris may have a hypoglycemic effect owing to its inhibitory effect on glucose levels and Ferula elaeochytris may also have a possible antioxidant source by means of the plant has a high capacity of total phenolic content. With the advanced studies to be done, it will be able to provide a more conscious utilization in accordance with the purpose of this unconsciously used plant by many people.

Özet

Günümüzde önemli bir sorun haline gelen diyabet, insülin sekresyonu, insülin etkisi veya her ikisindeki sorunlardan kaynaklanan hiperglisemi ile karakterize bir metabolik hastalıktır. Diyabet hastalığının vasküler ve nörojenik komplikasyonlarının gelişiminde oksidatif hasarın önemli rol oynadığını ve bu patolojiler üzerinde antioksidanların etkili olduğu bilinmektedir. Güney ve Güneydoğu Anadolu bölgesinde sıkça kullanılan “ÇAKŞIR” diye bilinen Ferula elaeochytris kök ekstresinin toplam fenolik içeriği ve glukozu inhibe edici etkisinin araştırılması amaçlanmıştır. Kahramanmaraş Engizek yaylasından toplatılan Ferula elaeochytris bitkisinin kök kısmı temiz ve kuru bir zeminde kurutulduktan sonra öğütülerek, işleme alınmak üzere hazırlanmıştır. Ferula eleaochytris’in glukoz üzerine etkisi biyosensör cihazı ile elektrokimyasal olarak; antioksidan etkinliğinin bir göstergesi olarak da Folin-Ciocalteu yöntemi ile toplam fenolik içeriği tayin edilmiştir. Bu çalışmada, biyosensör cihazı ile elektrokimyasal incelemesinde, Ferula elaeochytris kök ekstresinin 100’er µl kümülatif olarak 1 dakika (dk) aralıkla eklenmesi sonucu enzim-substrat etkileşiminin azalmasına bağlı olarak glukoz seviyeleri üzerinde doğrusal bir düşüş olduğu gözlemlenmiştir (N=120). Ayrıca, bu bitkinin Folin-Ciocalteu yöntemi ile toplam fenolik içeriği 41.45±2.38 mg GAE/g (n:3) olarak tespit edilmiştir. Ferula elaeochytris’in glukoz seviyesini inhibe edici etkisinden dolayı hipoglisemik ve toplam fenolik içeriğinin yüksek kapasiteye sahip olması yönüyle ise antioksidan kaynağına sahip olduğu söylenebilir. Yapılacak olan ileri çalışmalarla, insanlar tarafından bilinçsizce kullanılan bu bitkinin yerinde ve amacına uygun daha bilinçli bir kullanımı sağlanabilir.

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Cite This Article

ESER, N., KARTLAŞMIŞ, K., UÇAR, Y., KÖKBAŞ, U. (2020). Total Fenolic Contents of Ferula elaeochytris Root Extract and Its Effect on Glucose Levels. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, Cilt: 10 - Sayı: 2, 154–161. https://ajindex.com/articles/275721

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References (15)

  1. Cahill GF. The physiology of insulin in man. Diabetes 1971;20(12):785–99
  2. Atalay M, Laaksonen DE. Diabetes, oxidative stres and physical exercise. Journal of Sports Science and Medicine 2002;1:1-14. 3. de M Bandeira S, et al. Oxidative stress as an underlying contributor in the development of chronic complications in diabetes mellitus. International Journal of Molecular Sciences 2013;14(2):3265-84
  3. Azadzoi KM, Saenz de Tejada I. Diabetes mellitus impairs neurogenic and endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle. Journal of Urology 1992;148:1587-91
  4. Keegan A, Cotter MA, Cameron NE. Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats. Diabetologia 1999;42(3):343–350
  5. Gocmen C, et al. Effects of vitamin E and sodiumselenate on neurogenic and endothelial relaxation of corpus cavernosum in the diabetic mouse. European Journal of Pharmacology 2000;398(1):93–8
  6. Saenz de Tejada I, et al. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. New England Journal of Medicine 1989;320:1025-30
  7. Cameron NE, Cotter MA. Metabolic and vascular factors in the pathogenesis of diabetic neuropathy. Diabetes 1997;46(2):31–7
  8. Poli F, et al. Antiproliferative effects of daucane esters from Ferula communis and Ferula arrigonii on human colon cancer cell lines. Phytotherapy 2005;19(2):152-7
  9. Low PA, Nickander KK, Tritschler HJ. The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy. Diabetes 1997;46(2):38-42
  10. Kose EO, et al. Chemical composition, antimicrobial and antioxidant activity of essential oil of endemic Ferula lycia Boiss. Journal of medicinal plant research 2010;4(17):1698-703
  11. Lhuillier A, et al. Daucane sesquiterpenes from Ferula hermonis. Journal of Natural Products 2005;68(3):468–71
  12. Macho A, et al. Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line. Biochemical Pharmacology 2004;68(5):875–83
  13. Abu-Zaiton AS. Anti-diabetic activity of Ferula assafoetida extract in normal and alloxan-induced diabetic rats. Pakistan Journal of Biological Sciences 2010;13(2):97-100
  14. Fatehi M, Farifteh F, Fatehi-Hassanabad Z. Antispasmodic and hypotensive effects of Ferula asafoetida gum extract. The Journal of Ethnopharmacology 2004;91(2-3):321-4
  15. Singh R. In vitro evaluation of aqueous