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Journals / Kulak Burun Boğaz İhtisas Dergisi / 2017 / Cilt: 27 - Sayı: 3

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in malignant and precancerous laryngeal lesions

Malign ve prekanseröz larengeal lezyonlarda nötrofil lenfosit oranı ve trombosit lenfosit oranı

Suphi BULĞURCU
İLKER BURAK ARSLAN
Bünyamin DİKİLİTAŞ
İBRAHİM ÇUKUROVA
Pages
122–127
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

However, when evaluated in terms of clinical staging, PLR value was statistically different (p=0.047) while NLR value was not statistically different.Conclusion: To our knowledge, this is the first study to show that PLR can be used to differentiate precancerous laryngeal lesion and laryngeal squamous cell carcinoma.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study aims to investigate the relationship between neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients with precancerous laryngeal lesion or laryngeal squamous cell carcinoma.Patients and Methods: This retrospective study included 98 patients (92 males, 6 females; mean age 57.4±11.3 years; range 32 to 82 years) who were diagnosed to have precancerous laryngeal lesion or laryngeal squamous cell carcinoma according to histopathology result between January 2011 and June 2016.
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Key Findings & Data:Patients were divided into two groups as those with precancerous laryngeal lesion or laryngeal squamous cell carcinoma.Results: There was a statistically significant difference between the two groups in terms of NLR and PLR values (p=0.010, p=0.002, respectively).
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Conclusion & Impact:However, when evaluated in terms of clinical staging, PLR value was statistically different (p=0.047) while NLR value was not statistically different.Conclusion: To our knowledge, this is the first study to show that PLR can be used to differentiate precancerous laryngeal lesion and laryngeal squamous cell carcinoma.
🔬Design:Research Article
📍Scope:2011 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to investigate the relationship between neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients with precancerous laryngeal lesion or laryngeal squamous cell carcinoma.Patients and Methods: This retrospective study included 98 patients (92 males, 6 females; mean age 57.4±11.3 years; range 32 to 82 years) who were diagnosed to have precancerous laryngeal lesion or laryngeal squamous cell carcinoma according to histopathology result between January 2011 and June 2016. Patients were divided into two groups as those with precancerous laryngeal lesion or laryngeal squamous cell carcinoma.Results: There was a statistically significant difference between the two groups in terms of NLR and PLR values (p=0.010, p=0.002, respectively). When patients with laryngeal squamous cell carcinoma were evaluated in terms of lymph node metastasis, primary localization of tumor and differentiation of tumor; there was no statistically significant difference between NLR and PLR values. However, when evaluated in terms of clinical staging, PLR value was statistically different (p=0.047) while NLR value was not statistically different.Conclusion: To our knowledge, this is the first study to show that PLR can be used to differentiate precancerous laryngeal lesion and laryngeal squamous cell carcinoma.

Özet

Amaç: Bu çalışmada, prekanseröz larengeal lezyonu veya larengeal skuamöz hücreli karsinoması olan hastalarda nötrofil lenfosit oranı (NLO) ve trombosit lenfosit oranı (TLO) arasındaki ilişki araştırıldı.Hastalar ve Yöntemler: Bu retrospektif çalışmaya Ocak 2011 - Haziran 2016 tarihleri arasında histopatoloji sonucuna göre prekanseröz larengeal lezyon veya larengeal skuamöz hücreli karsinoma tanısı konulan 98 hasta (92 erkek, 6 kadın; ort. yaş 57.4±11.3 yıl; dağılım 32-82 yıl) dahil edildi. Hastalar prekanseröz larengeal lezyonlu veya larengeal skuamöz hücreli karsinomalı olmak üzere iki gruba ayrıldı.Bulgular: İki grup arasında NLO ve TLO değerleri açısından istatistiksel olarak anlamlı farklılık vardı (sırasıyla, p=0.010, p=0.002). Larengeal skuamöz hücreli karsinomalı hastalar lenf nodu metastazı, tümörün primer yerleşimi ve tümörün diferansiasyonu açısından değerlendirildiğinde, NLO ve TLO değerleri arasında istatistiksel olarak anlamlı farklılık yoktu. Ancak klinik evrelendirme açısından değerlendirildiğinde, TLO değeri istatistiksel olarak farklı (p=0.047), NLO değeri ise istatistiksel olarak farklı değildi.Sonuç: Bildiğimiz kadarıyla, bu çalışma, TLO'nun prekanseröz larengeal lezyon ve larengeal skuamöz hücreli karsinomanın ayrımında kullanabileceğini gösteren ilk çalışmadır.

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Cite This Article

BULĞURCU, S., ARSLAN, İ. B., DİKİLİTAŞ, B., ÇUKUROVA, İ. (2017). Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in malignant and precancerous laryngeal lesions. Kulak Burun Boğaz İhtisas Dergisi, Cilt: 27 - Sayı: 3, 122–127. https://ajindex.com/articles/274537

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