Journals / Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi / 2020 / Cilt: 34 - Sayı: 3

Neutrophil/Monocyte Ratio: A new predictor of inhospital mortality in patients with spontaneous ascites infections

Nötrofil/Monosit Oranı: Spontan assit enfeksiyonlarında hastane içi mortalite için yeni bir gösterge

Pages
243–252
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Successfully predicting mortality in SAI, easily calculated by a hemogram examination, and providing inexpensive, effective and fast results, neutrophil/monocyte ratio presents as a useful marker.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To determine the clinical features and in-hospital mortality predictors of spontaneous ascites infection (SAI).
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Key Findings & Data:Materials and Methods: In this retrospective study, 496 patients with liver cirrhosis hospitalized at the gastroenterology clinic between 2015-2019 were screened.
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Conclusion & Impact:Conclusion: Successfully predicting mortality in SAI, easily calculated by a hemogram examination, and providing inexpensive, effective and fast results, neutrophil/monocyte ratio presents as a useful marker.
🔬Design:Research Article
📍Scope:2015-2019 Verileri
⚙️Variables:siroz · assit · spontan assit enfeksiyonu

Abstract

Objective: To determine the clinical features and in-hospital mortality predictors of spontaneous ascites infection (SAI). Materials and Methods: In this retrospective study, 496 patients with liver cirrhosis hospitalized at the gastroenterology clinic between 2015-2019 were screened. Of the 304 cases with ascites, 80 diagnosed with SAI were included in the study. Results: Spontoneus ascites infections (SAI) was detected in 80 (16.1%) of 496 hospitalized patients with cirrhosis. In cirrhotic patients with SAI, the most common reason for presentation to the hospital was altered mental status, which was observed in 26 (32.5%) patients. Thirty-one (38.8%) patients were diagnosed with spontaneous bacterial peritonitis, 41 (51.2%) with culture-negative neutrocytic ascites, eight (10%) with monomicrobial non-neutrocytic bacteria ascites. In-hospital mortality was observed in 25 (31.3%) patients, and one-year mortality rate was 35% with total 28 patients. A high MELD-Na score, history of SAI, presence of hepatic encephalopathy at the time of hospitalization, and a neutrophil/monocyte ratio of >9.1 were determined as the predictors of in-hospital mortality. A neutrophil/monocyte ratio of >9.1 predicted in-hospital mortality at 72% sensitivity and 62% specificity. Conclusion: Successfully predicting mortality in SAI, easily calculated by a hemogram examination, and providing inexpensive, effective and fast results, neutrophil/monocyte ratio presents as a useful marker.

Özet

Amaç: Bu çalışmanın amacı spontan assit enfeksiyonunun (SAI) klinik özelliklerinin ve hastane içi mortalite prediktörlerinin belirlenmesidir. Gereç ve Yöntem: Bu çalışma retrospektif bir çalışmadır. Ocak 2015-Haziran 2019 arasında Gastroenteroloji bilim dalında yatan 496 karaciğer siroz hastası taranmıştır. 304 assitli olgudan SAI saptanan 80 olgu çalışmaya dâhil edilmiştir. Hastaların demografik, klinik ve laboratuar verileri kaydedilmiştir. Bulgular: Siroz tanısı ile yatan 496 olgudan 80 (%16,1)’inde SAI saptanmıştır. En sık hastaneye başvuru nedeni bilinç bulanıklığı olup, 26 hastada (%32,5) gözlenmiştir. Hastaların 31 (%38,8)’i spontan bakteriyel peritonit, 41 (%51,2)’i kültür-negatif nötrositik assit ve 8(%10)’i monomikrobiyal non-nötrositik bakterassit tanısı almıştır. Hastane içi mortalite 25 (%31,3) hastada gözlenmiş olup, bir yıllık total mortalite %35 oranında, toplam 28 hastada görülmüştür. Yüksek MELD-Na skoru, öyküde SAI, yatışta hepatik ensefalopati varlığı ve nötrofil/monosit oranının >9,1 olması hastane içi mortalite prediktörleri olarak saptanmıştır. Nötrofil/monosit oranının >9,1 olması hastane içi mortaliteyi %72 sensitivite ve %62 spesifite ile predikte etmiştir. Sonuç: Nötrofil/monosit oranının, SAI’de mortaliteyi predikte etmesi, hemogram tetkikinden basit olarak hesaplanabilmesi, ucuz, efektif ve hızlı sonuç vermesi nedeniyle bir belirteç olarak kullanılabileceği düşünülmüştür.

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Cite This Article

ÇELİK, F., ÜNAL, N. G., ŞENKAYA, A., KURTULMUŞ, İ. L. A., ASLANOV, S., Aydemir, S. Ş., TEKİN, F., ÖZÜTEMİZ, A. Ö., Fulya, F., karasu, Z. (2020). Neutrophil/Monocyte Ratio: A new predictor of inhospital mortality in patients with spontaneous ascites infections. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, Cilt: 34 - Sayı: 3, 243–252. https://ajindex.com/articles/274381

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