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Journals / Kafkas Üniversitesi Veteriner Fakültesi Dergisi / 2016 / Cilt: 22 - Sayı: 2

Tiroidektomize Ratlarda Serum IL-1?, IL-6, IL-10 ve TNF-? Seviyeleri

Serum IL-1?, IL-6, IL-10 and TNF-? Levels in Thyroidectomized Rats

SİNAN KANDIR
Ercan KESKIN
Pages
297–300
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, the obtained data suggest that elevated levels of cytokines could be as a consequence of thyroidectomy operation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study was conducted to determine the serum levels of interleukin (IL)-1?, IL-6, IL-10 and tumor necrosis factor alpha (TNF-?) in thyroidectomized rats.
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Key Findings & Data:Hypothyroidism was confirmed by elevated thyroid stimulating hormone (TSH) and decreased free tri-iodothyronine (fT3) levels (P<0.05) in thyroidectomized group.
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Conclusion & Impact:In conclusion, the obtained data suggest that elevated levels of cytokines could be as a consequence of thyroidectomy operation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This study was conducted to determine the serum levels of interleukin (IL)-1?, IL-6, IL-10 and tumor necrosis factor alpha (TNF-?) in thyroidectomized rats. Hypothyroidism was performed by surgical thyroidectomy in rats. Four weeks after from surgical procedure, selected cytokines levels were evaluated. Hypothyroidism was confirmed by elevated thyroid stimulating hormone (TSH) and decreased free tri-iodothyronine (fT3) levels (P<0.05) in thyroidectomized group. Serum IL-1?, IL-6, IL-10 levels have shown slight increase, whereas only TNF-? level (P<0.05) were significant statistically in thyroidectomized rats compared with control group. In conclusion, the obtained data suggest that elevated levels of cytokines could be as a consequence of thyroidectomy operation.

Özet

Bu çalışmada, tiroidektomize ratların serum interlökin (IL)-1?, IL-6, IL-10 and TNF-? düzeylerinin belirlenmesi amaçlanmıştır. Hipotiroidizm cerrahi yolla tiroidektomi yapılarak gerçekleştirildi. Cerrahi işlemden sonraki 4. haftada, seçili sitokinlerin seviyeleri ölçüldü. Hipotiroidizm, tiroidektomize grubun tiroid uyarıcı hormon (TSH) düzeyindeki artış (P<0.05) ve serbest tri-iyodotironin (fT3) düzeyindeki azalış (P<0.05) ile teyit edildi. Tiroidektomize ratların serum IL-1?, IL-6, IL-10 seviyelerinin kontrol grubuna kıyasla hafif düzeyde yükseldiği ancak, sadece TNF-? düzeyindeki artışın istatistiki olarak anlamlı (P<0.05) olduğu görüldü. Sonuç olarak elde edilen veriler, sitokin seviyelerindeki yükselmenin, tiroidektomi operasyonunun bir sonucu olabileceğini düşündürmektedir.

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Cite This Article

KANDIR, S., KESKIN, E. (2016). Tiroidektomize Ratlarda Serum IL-1?, IL-6, IL-10 ve TNF-? Seviyeleri. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 22 - Sayı: 2, 297–300. https://ajindex.com/articles/274142

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