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Journals / Kafkas Üniversitesi Veteriner Fakültesi Dergisi / 2016 / Cilt: 22 - Sayı: 2

Doğal Enfekte Karaciğer Kistik Ekinokokozisli Sığırlarda Plazma Sfingosin-1-fosfat, Total Sialik asit ve Adenozindeaminaz Arasından Potansiyel Biomarkerın Belirlenmesi

Determination of Potential Biomarker among Plasma Sphingosine-1-Phosphate, Total Sialic Acid and Adenosine Deaminase in Cattle with Naturally Infected Liver Cystic Echinococcosis

VAKILI Azad
Kaveh AZIMZADEH
Sohrab RASOULI
Pages
179–183
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, based on high sensitivity of TSA and ADA than S1P, they could be considered as potential biomarker in CE.

📌 3 Key Takeaways

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Objective & Hypothesis:The purpose of this trial was to assay the alterations of some blood parameters such as sphingosine 1 phosphate (S1P), total sialic acid (TSA) and adenosine deaminase (ADA) and clarification of possible potential biomarker among them in naturally infected liver cystic echinococcosis in cattle.
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Key Findings & Data:After observation of severe liver parasitic infestation (as cystic form) and blood sampling from parasitized and healthy ones, all selected biochemical analytes were clarified and results determined significant increase (P<=0.01) of aforementioned parameters in parasitized group rather than healthy ones.
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Conclusion & Impact:In conclusion, based on high sensitivity of TSA and ADA than S1P, they could be considered as potential biomarker in CE.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The purpose of this trial was to assay the alterations of some blood parameters such as sphingosine 1 phosphate (S1P), total sialic acid (TSA) and adenosine deaminase (ADA) and clarification of possible potential biomarker among them in naturally infected liver cystic echinococcosis in cattle. After observation of severe liver parasitic infestation (as cystic form) and blood sampling from parasitized and healthy ones, all selected biochemical analytes were clarified and results determined significant increase (P<=0.01) of aforementioned parameters in parasitized group rather than healthy ones. In conclusion, based on high sensitivity of TSA and ADA than S1P, they could be considered as potential biomarker in CE.

Özet

Bu çalışmanın amacı, doğal enfekte karaciğer kistik ekinokokozisli sığırlarda sfingozin-1-fosfat (S1P), total siyalik asit (TSA) ve adenozin deaminaz (ADA) için kan değerlerinin belirlenmesi ve böylece aralarından hangisinin muhtemel potansiyel bir biyomarker olabileceğinin belirlenmesidir. Parazitli olan (şiddetli kistik formu) ve sağlıklı sığırlardan kan örnekleri alındıktan sonra, belirtilen tüm biyokimyasal analizler yapıldı ve sonuçlar karşılaştırıldığında parazitli olan grupta anlamlı bir artış (P<=0.01) olduğu belirlendi. Sonuç olarak, TSA ve ADA S1P`e göre daha yüksek hassasiyetlik göstermesi sebebiyle, kistik ekinokokkozisde potansiyel biyomarker olarak değerlendirilebilir.

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Cite This Article

Azad, V., AZIMZADEH, K., RASOULI, S. (2016). Doğal Enfekte Karaciğer Kistik Ekinokokozisli Sığırlarda Plazma Sfingosin-1-fosfat, Total Sialik asit ve Adenozindeaminaz Arasından Potansiyel Biomarkerın Belirlenmesi. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 22 - Sayı: 2, 179–183. https://ajindex.com/articles/273609

References (7)

  1. Ergin S, Saribas S, Yuksel P, Zengin K, Midilli K, Adas G, Arikan S, Aslan M, Uysal H, Caliskan R, Oner A, Kucukbasmaci O, Kaygusuz A, Mamal Torun M, Kocazeybek B: Genotypic characterisation of Echinococcus granulosus isolated from human in Turkey. Afr J Microbiol Res, 4, 551-555, 2010.
  2. Latif AA, Tanveer A, Maqbool A, Siddiqi N, Kyaw-Tanner M, Traub RJ: Morphological and molecular characterisation of Echinococcus granulosus in livestock and humans in Punjab, Pakistan. Vet Parasitol, 170, 44-49, DOI: 10.1016/j.vetpar.2010.02.003 Pednekar RP, Gatne ML, Thompson RCA, Traub RJ: Molecular and morphological characterisation of Echinococcus from food producing animals in India. Vet Parasitol, 165, 58-65, 2009. DOI: 10.1016/j.vetpar. 06.021 Kowalski GM, Carey AL, Selathurai A, Kingwell BA, Bruce CR: Plasma sphingosine-1-phosphate is elevated in obesity. PLoS ONE, 8, e72449, DOI: 10.1371/journal.pone.0072449 NoferJ-R, MD, MBA: High density lipoprotein, sphingosine 1phosphate, and Atherosclerosis. J Clin Lipidology. 33, 48129, 2008. DOI: 10.1016/j. jacl.2007.11.002 Hanel P, Andreani P, Graler MH: Erythrocytes store and release sphingosine 1-phosphate in blood. FASEB J. 21, 1202-1209, 2007. DOI: 1096/fj.06-7433com Takuwa Y, Ikeda H, Okamoto Y, Takuwa N, Yoshioka K: Sphingosine- phosphate as a mediator involved in development of fibrotic diseases. Biochim Biophys Acta, 1831, 185-192, 2013. DOI: 10.1016/j.bbalip. 06.008 Guzel M, Askar TK, Kaya G, Atakisi E, Erbil Avci G: Serum sialic acids, total antioxidant capacity, and adenosine deaminase activity in cattle with therliriosis and anaplasmosis. Bull Vet Inst Pulawy, 52, 227-230, 2008.
  3. Citil M, Gunes V, Karapehlivan M, Atalan G, Marasli S: Evaluation of serum sialic acid as an inflammation marker in cattle with traumatic reticulo peritonitis. Rev Med Vet, 155, 389-392, 2004.
  4. Yurtsevan S, Uysal H: Decreased serum sialic acid, albumin-globulin ratio and total protein levels in cattle heavily infected with Theileria annulata. Ankara Üniv Vet Fak Derg, 56, 141-144, 2009.
  5. Chrostek L, Cylwik B, Panasiuk A, Brodowska-Adamusiak D, Gruszewska E: Lipid-bound sialic acid (LSA) in liver diseases of different etiologies. Annal Hepatology J, 10, 150-154, 2011.
  6. Gopi A, Madhavan SM, Sharma SK, Sahn SA: Diagnosis and treatment of tuberculosis pleural effusion in 2006. Chest, 131, 880-889, DOI: 10.1378/chest.06-2063
  7. Aydin I, Bulbul T, Polat ES, Yazar E: Serum antioxidant status and adenosine deaminase activity during the gestational per