Journals / Kafkas Üniversitesi Veteriner Fakültesi Dergisi / 2011 / Cilt: 17 - Sayı: 5

Kısa-Etkili Anesteziklerin Tavşanlarda Hemodinamik Fonksiyonlara Etkilerinin Doppler Ultrasonografi ile Değerlendirilmesi

Effects of Short-Acting Anaesthetics on Haemodynamic Function as Determined by Doppler Ultrasonography in Rabbits

Pages
713–719
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, comparing baseline values, propofol anaesthesia did not significantly alter RI measured from CCA and kidney and blood flow velocities measured from AA.

📌 3 Key Takeaways

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Objective & Hypothesis:This study was carried out to determine the effects of short-acting anaesthetics on haemodynamic function determined by Doppler ultrasonography.
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Key Findings & Data:Prior to anaesthesia, Doppler parameters [peak systolic blood flow velocity (psBFV), end-diastolic blood flow velocity (edBFV), minimum diastolic blood flow velocity (mdBFV) and resistive index (RI)] were obtained from the right common carotid artery (CCA), abdominal aorta (AA) and right kidney in New Zealand rabbits (n=24).
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Conclusion & Impact:In conclusion, comparing baseline values, propofol anaesthesia did not significantly alter RI measured from CCA and kidney and blood flow velocities measured from AA.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:anestetikler · ksilazin · hemodinamik

Abstract

This study was carried out to determine the effects of short-acting anaesthetics on haemodynamic function determined by Doppler ultrasonography. Prior to anaesthesia, Doppler parameters [peak systolic blood flow velocity (psBFV), end-diastolic blood flow velocity (edBFV), minimum diastolic blood flow velocity (mdBFV) and resistive index (RI)] were obtained from the right common carotid artery (CCA), abdominal aorta (AA) and right kidney in New Zealand rabbits (n=24). Animals were then divided into 3 groups to be anaesthetized with propofol (Group P), 2.5% thiopental sodium (Group T) and xylazine/ketamine HCl (Group XK). During anaesthesia the same Doppler measurements were made. Compared with baseline values, psBFV obtained from CCA increased in Group P (P<0.02) and insignificantly changed in Groups T and XK. psBFV measured from AA in Groups T and XK decreased as compared with baseline values. In the right kidney, psBFV in Group P and edBFV in Group T increased, whereas RI value in Groups T and XK decreased. In conclusion, comparing baseline values, propofol anaesthesia did not significantly alter RI measured from CCA and kidney and blood flow velocities measured from AA. The data suggest that propofol anaesthesia in rabbits results in minimal changes in Doppler parameters.

Özet

Bu çalışma, kısa etkili anesteziklerin Doppler ultrasonografi ile saptanan hemodinamik fonksiyonlara etkilerini belirlemek amacıyla yürütüldü. Anestezi öncesi Yeni Zelanda tavşanlarının (n=24) sağ arteria carotis communis (CCA), aorta abdominalis (AA) ve sağ böbreğinden Doppler parametreleri [en yüksek sistolik kan akım hızı (psBFV), diyastol sonu kan akım hızı (edBFV), en düşük diyastolik kan akım hızı (mdBFV) ve rezistif indeks (RI)] elde edildi. Hayvanlar propofol (Grup P), %2.5 tiyopental sodyum (Grup T) ve ksilazin/ketamin HCl (Grup XK) ile anestezi altına alınarak, üç grup oluşturuldu. Anestezi sırasında aynı ölçümler tekrarlandı. Bazal değerler ile karşılaştırıldığında CCA’dan elde edilen psBFV Grup P’de yükseldi ve Grup T ve XK’daki değişim önemsizdi. Grup T ve XK’da AA’dan ölçülen psBFV bazal değerler ile kıyaslandığında azaldı. Sağ böbrekte, Grup P’nin psBFV ve Grup T’nin edBFV değerleri artarken, Grup T ve XK’da RI değeri azaldı. Sonuç olarak, propofol anestezisi bazal parametreler ile karşılaştırıldığında, CCA’deki RI, intrarenal RI ve AA’daki kan akımı hızlarını önemli ölçüde değiştirmediği tespit edildi. Veriler propofol anestezisinin tavşanlarda Doppler parametrelerini minimal düzeyde etkilediğini göstermektedir.

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Cite This Article

KAYA, M., PEKCAN, Z., ŞEN, Y., ÖZGERMEN, D. B. B., ŞENEL, O. O., BUMİN, A. (2011). Kısa-Etkili Anesteziklerin Tavşanlarda Hemodinamik Fonksiyonlara Etkilerinin Doppler Ultrasonografi ile Değerlendirilmesi. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 17 - Sayı: 5, 713–719. https://ajindex.com/articles/273132

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References (13)

  1. Szatmari V, Sotonyi P, Vörös K: Normal duplex Doppler waveforms of the major abdominal blood vessels in dogs. A review. Vet Radiol Ultrasound, 42, 93-107, 2001.
  2. Riesen S, Schimd V, Gaschen L, Busato A, Lang J: Doppler measurement of splanchnic blood flow during digestion in unsedated normal dogs. Vet Radiol Ultrasound, 43, 554-560, 2002.
  3. Novellas R, Gopegui RR, Espada Y: Effects of sedation with midazolam and butorphanol on resistive and pulsatility indices in healthy dogs. Vet Radiol Ultrasound, 48, 276-280, 2007.
  4. Astrand H, Sandgren T, Ahlgren AR, Lanne T: Non-invasive ultra-sound measurements of aortic intima-media thickness: implications for in vivo study of aortic wall stress. J Vascular Surg, 37, 1270-1276, 2003.
  5. Drelich-Zbroja A, Jargiello T, Szymanska A, Krzyzanowski W, El-Furah M, Szczerbo-Trojanowska M: The diagnostic value of levovist in Doppler imaging of visceral arteries in patients with abdominal angina before and after angioplasty. Eur J Ultrasound, 16, 225-235, 2003.
  6. Lee H, Chang D, Lee Y, Eom K, Choi H, Seo K, Choi M, Yoon J: Use of color Doppler imaging for determining the resistive index of the medial long posterior ciliary artery in clinically normal conscious dogs. Am J Vet Res, 63, 211-214, 2002.
  7. Hofmeister EH, Williams CO, Braun C, Moore PA: Propofol versus thiopental: Effects on peri-induction intraocular pressures in normal dogs. Vet Anaesth Analg, 35, 275-281, 2008.
  8. Hall LW, Clarke KM, Trim CM: General pharmacology of the injectable agents used in anaesthesia. In, Veterinary Anaesthesia. 10rd ed, pp. 113-129. WB Saunders Co. 2001
  9. VanNatta ME, Rex DK: Propofol alone titrated to deep sedation versus propofol in combination with opioids and/or benzodiazepines and titrated to mo derate sedation for colonoscopy. Am J Gastroenterol, 101: 2209-2217, 2006.
  10. Difilippo SM, Norberg PJ, Suson UD, Savino AM, Reim DA: A comparison of xylazine and medetomidine in an anaesthetic combination in New Zealand white rabbits. Contemp Top Lab Anim Sci, 43, 32-34, 2004.
  11. Muir WW, Skarda RT, Milne DW: Evaluation of xylazine and ketamine hydrochloride anesthesia in horses. Am J Vet Res, 38, 195-201, 1977.
  12. Rivers BJ, Walter PA, Letourneau JG, Finlay DE, Ritenour ER, King VL, O’Brien TD, Polzin DJ: Duplex Doppler estimation of resistive index in arcuate arteries of sedated, normal female dogs: Implications for use in the diagnosis of renal failure. J Am Anim Hosp Assoc, 33, 69-76, 1997.
  13. Lee SW, Hankes GH, Purohit RC, Bartels JE, Cartee RE, Pablo L, Conti JC: