Journals / Kafkas Üniversitesi Veteriner Fakültesi Dergisi / 2012 / Cilt: 18 - Sayı: 4

Theileriosisli sığırlarda oksidatif stresin paraoksonaz aktivitesi, ısı şok protein ve lipid profili düzeyleri ile belirlenmesi

The determination of oxidative stress by paraoxonase activity, heat shock protein and lipid profile levels in cattle with theileriosis

Pages
647–651
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, serum lipid profile could play role in pathogenesis of theileriosis because of the biochemical changes, such as degeneration of liver and increased levels of lipolysis for compansate the energy requirement which was increased due to theileriosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Theileriosis is a common illness that cause large economic losses.
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Key Findings & Data:In the study, 15 healty cattle and 15 cattle with tropical theileriosis, between 1-3 years old, were used.
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Conclusion & Impact:In conclusion, serum lipid profile could play role in pathogenesis of theileriosis because of the biochemical changes, such as degeneration of liver and increased levels of lipolysis for compansate the energy requirement which was increased due to theileriosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:karaciğer · Theileria · kan lipitleri

Abstract

Theileriosis is a common illness that cause large economic losses. The aim this study was to define the oxidative status by determining the changes in levels of malondialdehyde, heat shock protein, paraoxonase activity and lipid profile (triglycerides, total cholesterol, very low-density lipoprotein, low-density lipoprotein, high-density lipoprotein) in cattle with tropical theileriosis. In the study, 15 healty cattle and 15 cattle with tropical theileriosis, between 1-3 years old, were used. Plasma malondialdehyde (P<0.001) and heat shock protein 27 (P<0.01) levels were determined significantly higher in cattles with Theileriosis than the control group. On the other hand, serum paraoxonase level was significantly lower than the control group. According to lipid profile analyses, while serum trigliserid (P<0.001) and very low-density lipoprotein (P<0.01) levels were found significantly higher in cattles with theileriosis, serum total cholesterol (P<0.001), low-density lipoprotein (P<0.001) and high-density lipoprotein (P<0.001) levels were found significantly lower in cattles with theileriosis than the control group. In conclusion, serum lipid profile could play role in pathogenesis of theileriosis because of the biochemical changes, such as degeneration of liver and increased levels of lipolysis for compansate the energy requirement which was increased due to theileriosis. In addition, determination of serum paraoxonase activity and heat shock protein 27 levels may be useful tools in the determination of oxidative stress in tropical theileriosis.

Özet

Theileriosis, yaygın olarak görülen ve büyük ekonomik kayıplara neden olan bir hastalıktır. Bu çalışmada; theileriosisli sığırlarda, akut dönemde oksidatif stres etkisinin ısı şok protein düzeyleri, paraoksonaz aktivitesi ve lipid profili analizi (trigliserid, total kolesterol, çok düşük dansiteli lipoprotein, düşük dansiteli lipoprotein, yüksek dansiteli lipoprotein) ile ortaya konulması amaçlanmaktadır. Çalışma, 1-3 yaş arasında 15 sağlıklı ve 15 theileriosisli sığırda gerçekleştirilmiştir. Theileriosisli sığırlarda plazma malondialdehit (P<0.001) ve ısı şok protein 27 (P<0.01) düzeyleri kontrol grubuna göre yüksek bulunmuştur. Serum paraoksonaz düzeyi ise, kontrol grubuna göre düşük (P<0.001) bulunmuştur. Yapılan lipid profili analizlerinde ise, Theileriosisli sığırlarda kontrol grubuna göre serum trigliserid (P<0.001) ve çok düşük dansiteli lipoprotein (P<0.01) düzeyleri yüksek bulunurken, total kolesterol (P<0.001), düşük dansiteli lipoprotein (P<0.001) ve yüksek dansiteli lipoprotein (P<0.001) düzeyleri ise düşük bulunmuştur. Sonuç olarak, Theileriosiste artan enerji ihtiyacının karşılanması için yağların lipolizinin artması ve karaciğer hasarının oluşması gibi çeşitli biyokimyasal değişimler nedeni ile plazma lipid profili theileriosisin patogenezinde rol oynayabileceği düşünülmektedir. Ayrıca serum paraoksonaz aktivitesi ve ısı şok protein 27 düzeyinin belirlenmesi, tropikal theileriosisde oksidatif stres etkisinin belirlenmesinde yararlı bir indikatör olabileceği kanısına varılmıştır.

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Cite This Article

TURUNÇ, V., AŞKAR, T. K. (2012). Theileriosisli sığırlarda oksidatif stresin paraoksonaz aktivitesi, ısı şok protein ve lipid profili düzeyleri ile belirlenmesi. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 18 - Sayı: 4, 647–651. https://ajindex.com/articles/273079

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