Journals / Kafkas Üniversitesi Veteriner Fakültesi Dergisi / 2016 / Cilt: 22 - Sayı: 6

Köpek Meme Tümörlerinde B-Mode Ekodesen Analizi ve Renkli Doppler Ultrasonografi

B-mode Echotexture Analysis and Color Doppler Sonography in Canine Mammary Tumors

Pages
961–969
DOI
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⚡ TL;DR(Too Long; Didn't Read)

On the other hand, there was a positive correlation between tumor size and GV (0.961/P<0.05) in malignant tumors

📌 3 Key Takeaways

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Objective & Hypothesis:Forty-one mammary gland tumors from twenty eight bitches were used for the study.
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Key Findings & Data:Statistical analysis of the HOM and GV parameters indicated that there was a significant difference between benign (3.10 and 1.14) and malignant tumors (1.54 and 0.57; P<0.01).
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Conclusion & Impact:On the other hand, there was a positive correlation between tumor size and GV (0.961/P<0.05) in malignant tumors
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Forty-one mammary gland tumors from twenty eight bitches were used for the study. Ultrasonographic examinations of tumor masses were performed before surgical excision and a quadratic region-of-interest (ROI) was chosen randomly on B-mode tumor images for the echotexture analyses. All tumors were evaluated histopathologically after surgery. Contrast (CONT), Mean Gradient (MG), Mean Value (MV), Homogeneity (HOM), Entropy (ENTR) and Gray Value (GV) parameters were used for the texture analyses of ultrasonographic images. Ultrasonographic image characteristics were additionally evaluated by the following macroscopic patterns: tumor shape, invasion of tumor to surrounding tissue, tumor border sharpness, echogenicity of tumor, hyperechogenic artifact, anechogenic artifact, and shadow around tumor. After B-mode ultrasonographic examination, Pulsatility Index (PI), Resistive Index (RI), Peak Systolic Flow Velocity (Vmax) and Number of Color Pixel (CP) parameters were evaluated by means of color Doppler sonography. Statistical analysis of the HOM and GV parameters indicated that there was a significant difference between benign (3.10 and 1.14) and malignant tumors (1.54 and 0.57; P<0.01). Besides, a significant difference was found between images of MalignantMixed Tumors (MMT) and Benign-Mixed Tumors (BMT) with regard to CONT and HOM (p< 0.001). In addition, MV was significantly higher in malignant tumors in comparison to the benign cases (P<0.05). A significant negative correlation was found between tumor size and MV in malignant tumor and adenocarcinoma cases (-0.991/ P<0.05; -0.999/P<0.01, respectively). On the other hand, there was a positive correlation between tumor size and GV (0.961/P<0.05) in malignant tumors

Özet

Çalışma için 28 dişi köpeğe ait olan 41 meme tümörü dokusu kullanılmıştır. Cerrahi eksizyon öncesi tümörlü kitleler B-Mode ultrasonografik muayene ile incelenmiş, görüntüler digital olarak kayıt edilmiş ve ekodesen analizi için bu görüntüler üzerinde rastgele olarak dörtlü inceleme alanları (Region of Interest) seçilmiştir. Tüm tümörlü dokular, cerrahi eksizyon sonrası histopatolojik olarak incelenmiştir. Ultrasonografik resimlerin yapısal analizleri için, Kontrast (CONT), Ortalama Gradyan (MG), Ortalama Değer (MV), Homojenite (HOM), Entropi (ENTR) ve Gri Değer (GV) parametreleri kullanılmıştır. Ultrasonografik resimler ek olarak tümör kitlesi, tümör şekli, tümörün çevre dokulara invazyonu, tümör sınır keskinliği, tümörün ekojenitesi, hiperekojenik artefakt, anekojenik artefakt ve tümör etrafındaki gölgelenme gibi makroskopik parametreler açısından da değerlendirilmiştir. B-Mod ultrasonografik muayenenin ardından, renkli Doppler ile Pulzatil İndeks (PI), Rezistif İndeks (RI), Pik Sistolik Akım Hızı (Vmax) ve Renkli Piksel Sayısı (CP) parametreleri değerlendirilmiştir. İstatistiki analizler sonucunda HOM ve GV parametreleri açısından, benign (3.10 ve 1.14) ve malign (1.54 ve 0.57; P<0.01) tümörler arasında önemli farklar bulunmuştur. Ayrıca CONT ve HOM parametreleri açısından Malign Miks Tümörler (MMT) ve Benign Miks Tümörler (BMT) arasında önemli farklar (P<0.001) bulunmuştur. Ek olarak, MV malign tümörlerde, benign tümörlere göre önemli düzeyde (P<0.05) yüksek bulunmuştur. Tümör büyüklüğü ve MV arasında, malign tümörlerde ve adenokarsinomlarda önemli düzeyde negatif korrelasyon saptanmıştır (sırası ile -0.991/P<0.05; -0.999/P<0.01). Diğer yandan malign tümörlerde tümör büyüklüğü ve GV arasında pozitif korrelasyon saptanmıştır (0.961/P< 0.05)

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Cite This Article

MÜLAZIMOĞLU, S. B., BECERİKLİSOY, H. B., SCHAFER-SOMI, S., KAYA, M., BUMİN, A., ÖZENÇ, E., GÜLTİKEN, N., KANCA, H., GÜNEN, M. Z., KUTSAL, O., EMRE, B., EVANGELOS, K., ASLAN, S. (2016). Köpek Meme Tümörlerinde B-Mode Ekodesen Analizi ve Renkli Doppler Ultrasonografi. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 22 - Sayı: 6, 961–969. https://ajindex.com/articles/272460

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References (9)

  1. Madewell BR, Theilen GH: Tumors of the mammary gland. In, Theilen GH, Madewell BR (Eds): Veterinary Cancer Medicine. 327-344, Lea & Febiger, Philadelphia, 1987.
  2. Macewen EG, Withrow SJ: Tumours of the mammary gland. In, MacEwen EG, Winthrow SJ (Eds): Small Animal Clinical Oncology. 3rd ed., 356-379,
  3. WB Saunders, Philadelphia, 1996. Priester WA: Multiple primary tumors in domestic animals: A preliminary view with particular emphasis on tumors in dogs. Cancer,, 1845-1848, 1977. DOI: 10.1002/1097-0142(197710)40:4+_____1845::AID- CNCR2820400812>3.0.CO;2-8
  4. Brodey RS, Goldschmidt MH, Roszl JR: Canine mammary gland neoplasms. J Am Anim Hosp Assoc, 19, 61-90, 1983. Gorman NT: The Mammary Glands. In, White RAS (Ed): Manual of Small Animal Oncology. 201-205, British Small Animal Veterinary Association, Cheltenham, 1991.
  5. Hellmen E, Bergstrom R, Holmberg L, Spangberg IB, Hansson K, Lindgren A: Prognostic factors in canine mammary tumours: A multivariate study of 202 consecutive cases. Vet Pathol, 30, 20-27, 1993. DOI: 10.1177/030098589303000103 Frese K, Durchfeld B, Eskens U: Classification and biological behaviour of skin's and mammary tumors in dogs and cats. Prakt Tierartzt, 70, 69-, 1989.
  6. Nyman HT, Kristensen AT, Lee MH, Martinussen T, Mcevoy FJ: Characterization of canine superficial tumors using gray-scale B mode, color flow mapping, and spectral doppler ultrasonography - A multivariate study. Vet Radiol Ultrasound, 47, 192-198, 2006. DOI: 10.1111/j.1740- 2006.00127.x Poulsen-Nautrup C, Tobias CR: Atlas und Lehrbuch der Ultraschalldiagnostik bei Hund und Katze. Schlütersche Verlagsanstalt, Hannover, 1999.
  7. Simon D, Schönröck D, Ueberschär S, Siebert J, Nolte I: Mammatumoren des hundes: Diagnostik und therapie. Tierärztl Prax, 29, 50, 2001.
  8. Marquardt C, Burkhardt E, Failing K: Sonographic examination of mammary tumors in bitches. Part I: Individual criteria detectable by sonography and their correlation with tumor dignity. Tierärztl Prax, 31, 283, 2003.
  9. Marquardt C, Wehrend A, Burkhardt E: Sonographic examination of mammary tumors in bitches. Part II: Preoperative sonographic evaluation of dignity. Tierärztl Prax, 33, 23-26, 2005. Hitzer U: Untersuchungen zur sonographischen Darstellung der primären Multiplizität von caninen Mammatumoren. Dissertation, Berlin, Peters-Engl C, Medl M, Mirau M, Wanner C, Bilgi S, Sevelda P, Obermair A: Color-coded and spectral Doppler flow in breast carcinomas Relationship with the tumor microvasculature. Breast Cancer Res Treat,,