Journals / Kafkas Üniversitesi Veteriner Fakültesi Dergisi / 2016 / Cilt: 22 - Sayı: 3

Şap Hastalıklı Boğalarda Serum ve Salya Sialik Asit ve Oksidatif Stres Parametrelerindeki Değişiklikler

Serum and Saliva Sialic Acid and Oxidative Stress Parameters Changes in Bulls with Foot and Mouth Disease [1]

Pages
321–326
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, showing signs of foot and mouth disease in bulls, serum and saliva in sialic acid and oxidative stress parameters are affected very significantly.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The study comprised of 12 bulls, aged between 18-36 months, determined severe symptoms of Foot-and-mouth disease (FMD) and 10 clinically healthy bulls of similar age.
📊
Key Findings & Data:Mean serum SA, MDA, GSH and NO levels were 503.96±21.43 mg/L, 31.82±3.43 µmol/L, 63.43±2.92 mg/dL, and 6.49±0.36 nmol/L in healthy bulls and 862.01±17.35 mg/L, 82.49±9.90 µmol/L, 24.96±2.32 mg/dL, and 13.89±0.53 nmol/L in FMD cases, respectively.
💡
Conclusion & Impact:As a result, showing signs of foot and mouth disease in bulls, serum and saliva in sialic acid and oxidative stress parameters are affected very significantly.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The study comprised of 12 bulls, aged between 18-36 months, determined severe symptoms of Foot-and-mouth disease (FMD) and 10 clinically healthy bulls of similar age. Serum and saliva total sialic acid (SA), malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) levels were measured. In this study were determined acute fever, anorexia, vesicular lesions in the mouth and feet of infected animals with consequent excessive salivation, lameness and reduced productivity as clinical signs. Mean serum SA, MDA, GSH and NO levels were 503.96±21.43 mg/L, 31.82±3.43 µmol/L, 63.43±2.92 mg/dL, and 6.49±0.36 nmol/L in healthy bulls and 862.01±17.35 mg/L, 82.49±9.90 µmol/L, 24.96±2.32 mg/dL, and 13.89±0.53 nmol/L in FMD cases, respectively. Mean saliva SA, MDA, GSH and NO levels were 75.98±10.25 mg/L, 1.06±0.17 µmol/L, 0.67±0.05 mg/dL, and 1.44±0.14 nmol/L in healthy bulls and 156.49±14.07 mg/L, 1.81±0.15 µmol/L, 0.34±0.03 mg/dL, and 2.44±0.16 nmol/L in FMD cases, respectively. The differences between the two groups were statistically significant (P<0.001 and P<0.01). Mean serum and saliva GSH level was lower in FMD while all other parameters were considerable high. As a result, showing signs of foot and mouth disease in bulls, serum and saliva in sialic acid and oxidative stress parameters are affected very significantly.

Özet

Bu çalışmada 18-36 ay yaşları arasında klinik açıdan şiddetli şap belirtileri tespit edilen 12 ve aynı yaş aralığındaki sağlıklı 10 adet boğa değerlendirildi. Serum ve salyada total sialik asit (SA), malondialdehit (MDA), glutathione (GSH) ve nitrik oksit (NO) düzeyleri ölçüldü. Çalışmada klinik belirtiler olarak; akut ateş, iştahsızlık, ağızda çok yaygın veziküler lezyonlar ve buna bağlı aşırı salivasyon, şiddetli topallık ve verim düşüklüğü belirlendi. Sağlıklı boğalarda ortalama serum SA, MDA, GSH ve NO düzeyleri sırasıyla 503.96±21.43 mg/L, 31.82±3.43 µmol/L, 63.43±2.92 mg/dL ve 6.49±0.36 nmol/L, şaplı olarak değerlendirilen boğalarda ise 862.01±17.35 mg/L, 82.49±9.90 µmol/L, 24.96±2.32 mg/dL ve 13.89±0.53 nmol/L olarak belirlendi. Sağlıklı boğalardan elde edilen salyalarda ortalama SA, MDA, GSH ve NO düzeyleri sırasıyla 75.98±10.25 mg/L, 1.06±0.17 µmol/L, 0.67±0.05 mg/dL ve 1.44±0.14 nmol/L iken bu değerler şaplı olarak değerlendirilen boğalarda 156.49±14.07 mg/L, 1.81±0.15 µmol/L 0.34±0.03 mg/dL ve 2.44±0.16 nmol/L, olarak tespit edildi. İki grup arasındaki farkın istatistiksel olarak anlamlı olduğu belirlendi (P<0.001 ve P<0.01). Şaplı olarak değerlendirilen hayvanlarda serum ve salya GSH değerleri düşük, diğer parametreler ise yüksek olarak tespit edildi. Sonuç olarak şap belirtileri tespit edilen boğalardan elde edilen serum ve salyada sialik asit ve oksidatif stres parametrelerinin önemli derecede etkilendiği belirlendi.

🔖

Cite This Article

UZLU, E., KARAPEHLİVAN, M., ERDOĞAN, H. M., KIZILTEPE, Ş., ERKILIÇ, E. E., DEVECİ, H. A., GÖKÇE, E., KAYA, İ., ÇİTİL, M. (2016). Şap Hastalıklı Boğalarda Serum ve Salya Sialik Asit ve Oksidatif Stres Parametrelerindeki Değişiklikler. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 22 - Sayı: 3, 321–326. https://ajindex.com/articles/272448

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (6)

  1. Thompson D, Muriel P, Russell D, Osborne P, Bromley A, Rowland M, Creigh-Tyte S, Brown C: Economic costs of the foot and mouth disease outbreak in the United Kingdom in 2001. Rev Sci Tech OffInt Epiz,, 675-687, 2002.
  2. Alexandersen S, Zhang Z, Donaldson AI, Garland AJ: The Patho- genesis and diagnosis of foot-and-mouth disease. J Comp Pathol, 129, 36, 2003. DOI: 10.1016/S0021-9975(03)00041-0
  3. Alexandersen S, Mowat N: Foot-and-mouth disease: Host range and pathogenesis. Curr Top Microbiol Immunol, 288, 9-42, 2005. DOI: 1007/3-540-27109-0_2 Carrillo C, Tulman ER, Delhon G, Lu Z, Carreno A, Vagnozzi A, Kutish GF, Rock DL: Comparative genomics of foot-and-mouth disease virus. J Virol, 79, 6487-6504, 2005. DOI: 10.1128/JVI.79.10.6487-6504.2005
  4. Domingo E, Pariente N, Airaksinen A, Gonzalez-Lopez C, Sierra S, Herrera M, Grande-Pérez A, Lowenstein PR, Manrubia SC, Lázaro E, Escarmís C: Foot-and-mouth disease virus evolution: Exploring pathways towards virus extinction. Curr Top Microbiol Immunol, 288, 149-173, 2005. DOI: 10.1007/3-540-27109-0_7 Grubman MJ, Baxt B: Foot-and-mouth disease. Clin Microbiol Rev, 17, 493, 2004. DOI: 10.1128/CMR.17.2.465-493.2004
  5. Sellers R, Gloster J: Foot-and-mouth disease: A review of intranasal infection of cattle, sheep and pigs. Vet J, 177, 159-168, 2008. DOI: 1016/j.tvjl.2007.03.009 De la Rua R, Watkins GH, Watson PJ: Idiopathic mouth ulcers in sheep (letter). Vet Rec, 149, 30-31, 2001. Watson P: The differential diagnosis of FMD in sheep in the UK in 2001. State Vet J, 20-24, 2002. Kitching RP: Clinical variation in foot and mouth disease: Cattle. Revue Sci Tech, Office Internat Epizoo, 21, 499-504, 2002. Watson P: Differential diagnosis of oral lesions and FMD in sheep. In Pract, 26, 182-191, 2004. DOI: 10.1136/inpract.26.4.182 Kitching RP, Hutber AM, Thrusfield MV: A review of foot-and-mouth disease with special consideration for the clinical and epidemiological factors relevant to predictive modelling of the disease. Vet J, 169, 197-209, DOI: 10.1016/j.tvjl.2004.06.001 Ryan E, Gloster J, Reid SM, Li Y, Ferris NP, Waters R, Juleff N, Charleston B, Bankowski B, Gubbins S, Wilesmith JW, King DP, Paton DJ: Clinical and laboratory investigations of the outbreaks of foot-and- mouth disease in southern England in 2007. Vet Rec, 163, 139-147, 2008. DOI: 10.1136/vr.163.5.139 Schauer R: Chemistry, metabolism and biological functions of sialic acid. Carbohydrate Chem Biochem, 40, 131-234, 1982.
  6. Haq M, Haq S, Tutt P, Crook M: Serum total sia