SavedAdd your journal

Journals / Journal of Clinical Research in Pediatric Endocrinology / 2017 / Cilt: 9 - Sayı: 2

Congenital Hypothyroidism and Bone Remodeling Cycle

NAZMİ MUTLU KARAKAŞ
Sibel Tulgar KINIK
Beril ÖZDEMİR
Nursel MURATOĞLU ŞAHİN
M. Agah TEKİNDAL
Ayşegül HABERAL
Pages
106–110
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our results suggest that with effective vitamin D treatment and thyroxin replacement, congenital hypothyroidism is not a deleterious factor for bone turnover.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The present study aimed to evaluate the biochemical markers of bone turnover in children with congenital hypothyroidism during the course of treatment as compared to healthy children selected as controls.Methods: The study included 31 children with congenital hypothyroidism and 29 healthy children.
📊
Key Findings & Data:In both groups, we evaluated serum procollagen type-1 N-terminal propeptide (PINP) and tartrate-resistant acid phosphatase type 5b isoform (TRACP 5b) levels as bone turnover markers.
💡
Conclusion & Impact:Our results suggest that with effective vitamin D treatment and thyroxin replacement, congenital hypothyroidism is not a deleterious factor for bone turnover.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The present study aimed to evaluate the biochemical markers of bone turnover in children with congenital hypothyroidism during the course of treatment as compared to healthy children selected as controls.Methods: The study included 31 children with congenital hypothyroidism and 29 healthy children. In both groups, we evaluated serum procollagen type-1 N-terminal propeptide (PINP) and tartrate-resistant acid phosphatase type 5b isoform (TRACP 5b) levels as bone turnover markers. Results: In both groups, thyroid hormone levels were within normal limits. The levels of vitamin D were significantly higher in the cases with congenital hypothyroidism. Although PINP levels were not found to be different, TRACP 5b levels which are related to osteoclastic activities were significantly higher in the control group. Conclusion: We did not detect an increase in bone resorption in patients with congenital hypothyroidism, despite long-term treatment with LT4. Our results suggest that with effective vitamin D treatment and thyroxin replacement, congenital hypothyroidism is not a deleterious factor for bone turnover.

🔖

Cite This Article

KARAKAŞ, N. M., KINIK, S. T., ÖZDEMİR, B., ŞAHİN, N. M., TEKİNDAL, M. A., HABERAL, A. (2017). Congenital Hypothyroidism and Bone Remodeling Cycle. Journal of Clinical Research in Pediatric Endocrinology, Cilt: 9 - Sayı: 2, 106–110. https://ajindex.com/articles/270480

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Klein AH, Meltzer S, Kenny FM. Improved prognosis in congenital hypothyroidism treated before age three months. J Pediatr 1972;81:912-915.
  2. Dussault JH, Coulombe P, Laberge C, Letarte J, Guyda H, Khoury K. Preliminary report on a mass screening program for neonatal hypothyroidism. J Pediatr 1975;86:670-674.
  3. Gogakos AI, Duncan Basset JH, Williams GR. Thyroid and bone. Arch Biochem Biophys 2010;503:129-136. Epub 2010 Jun 23 Leger J, Ruiz JC, Guibourdenche J, Kindermans C, Garabedian M, Czernichow P. Bone mineral density and metabolism in children with congenital hypothyroidism after prolonged L-thyroxine therapy. Acta Pediatr 1997;86:704-710.
  4. Stall GM, Harris S, Sokoll LJ, Dawson-Hugues B. Accelerated bone loss in hypothyroid patients overtreated with L-thyroxine. Ann Intern Med 1990;113:265-269.
  5. Diamond T, Nery L, Hales I. A therapeutic dilemma: suppresive doses of thyroxine significiantly reduce bone mineral measurements in both premenopausal and postmenopausal women with thyroid carcinoma. J Clin Endocrinol Metab 1991;72:1184-1188.
  6. Franklyn JA, Betteridge J, Daykin J, Holder R, Oates GD, Parle JV, Lilley J, Heath DA, Sheppard MC. Long-term thyroxine treatment and bone mineral density. Lancet 1992;340:9-13.
  7. Marcocci C, Golia F, Bruno-Bossio G, Vignali E, Pinchera A. Carefully monitored levothyroxine suppressive therapy in not associated with bone loss in premenopausal women. J Clin Endocrinol Metab 1994;78:818-823.
  8. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M, Kappy M; Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008;122:398-417. Jürimae J. Interpretion and application of bone turnover markers in children and adolescents. Curr Opin Pediatr 2010;22:494-500.
  9. Civitelli R, Armanento-Villareal R, Napoli N. Bone turnover markers: understanding their value in clinical trails and clinical practice. Osteoporos Int 2009;20:843-851. Epub 2009 Feb 4 Bassett JH, Williams GR. Critical role of the hypothalamic-pituitary- thyroid axis in bone. Bone 2008;43:418-426. Epub 2008 May 16 Papadimitriou A, Papadimitriou DT, Papadopoulou A, Nicolaidou P, Fretzayas A. Low TSH levels are not associated with osteoporosis in childhood. Eur J Endocrinol 2007;157;221-223.
  10. Engler H, Oettli RE, Riesen WF. Biochemical markers of bone turnover in patients with tyhroid dysfunctions and in euthyroid controls: a cross- sectional stud