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Journals / International Journal of Medical Biochemistry / 2020 / Cilt: 3 - Sayı: 2

Change in vitamin B12 level in breast milk according to the week of delivery in Turkish women

Fatih YEŞİLDAL
Esin KOÇ
Hakan ÖZTÜRK
Taner ÖZGÜRTAŞ
Pages
96–100
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to these results, preterm delivery infants do not require additional vitamin B12 supplementation unless there is a pathology of the maternal or infant vitamin metabolism, or there is a problem performing breastfeeding.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Vitamin B12 is one of the most important micronutrients in breast milk, as a deficiency can lead to growth and developmental retardation in infants.
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Key Findings & Data:The aim of this study was to investigate differences in the level of vitamin B12 in breast milk in preterm, late preterm, and term groups according to the number of gestational weeks at delivery, and how vitamin B12 content in breast milk changed during the first 28 days of lactation.
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Conclusion & Impact:According to these results, preterm delivery infants do not require additional vitamin B12 supplementation unless there is a pathology of the maternal or infant vitamin metabolism, or there is a problem performing breastfeeding.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: Vitamin B12 is one of the most important micronutrients in breast milk, as a deficiency can lead to growth and developmental retardation in infants. The aim of this study was to investigate differences in the level of vitamin B12 in breast milk in preterm, late preterm, and term groups according to the number of gestational weeks at delivery, and how vitamin B12 content in breast milk changed during the first 28 days of lactation. Methods: A total of 30 mothers (n=10 each for preterm, late preterm, and term delivery groups) were included in the study. Breast milk samples were collected from the participants on day 3, 7, and 28 after delivery. The level of vitamin B12 was analyzed in each sample using the Advia Centaur XP autoanalyzer (Siemens Healthineers GmbH, Erlangen, Germany). Analysis of variance (ANOVA) and post hoc Tukey tests were used for group comparisons. Results: There was a significant difference in the level of vitamin B12 between the 3 groups based on the week of delivery (ANOVA test, p=0.012). In addition, regardless of the number of days of lactation, a significant difference was found between the preterm (954.1±462.8 ng/L) and term (647±253.2 ng/L) groups in the post hoc Tukey pairwise comparison results (p=0.010). The vitamin B12 level in the 28th day breast milk samples was significantly different between the preterm group (1104.1±431.9 ng/L) and the term group (547.1±274.4 ng/L) (p=0.030). Conclusion: In the term delivery group, the highest level of vitamin B12 was seen in the colostrum, and was lower in transition milk and mature milk. In contrast, in the preterm delivery group, mature milk contained a higher level of vitamin B12 than the colostrum. The vitamin B12 level in breast milk in the preterm group was higher on the 28th day of lactation compared with the term group. This may be a compensation mechanism to prevent possible retardation of growth in the preterm group. According to these results, preterm delivery infants do not require additional vitamin B12 supplementation unless there is a pathology of the maternal or infant vitamin metabolism, or there is a problem performing breastfeeding.

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Cite This Article

YEŞİLDAL, F., KOÇ, E., ÖZTÜRK, H., ÖZGÜRTAŞ, T. (2020). Change in vitamin B12 level in breast milk according to the week of delivery in Turkish women. International Journal of Medical Biochemistry, Cilt: 3 - Sayı: 2, 96–100. https://ajindex.com/articles/270345

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References (14)

  1. Kramer MS, Kakuma R. Optimal duration of exclusive breastfeeding. Cochrane Database Syst Rev 2012;(8):CD003517
  2. Allen LH. B vitamins in breast milk: relative importance of maternal status and intake, and effects on infant status and function. Adv Nutr 2012;3(3):362–9
  3. Allen L, Shrimpton R. The International Research on Infant Supplementation study: implications for programs and further research. J Nutr 2005;135(3):666S–9S
  4. Lartey A, Manu A, Brown KH, Dewey KG. Predictors of micronutrient status among six- to twelve-month-old breast-fed Ghanaian infants. J Nutr 2000;130(2):199–207
  5. Allen LH, Hampel D. Water-Soluble Vitamins in Human Milk Factors Affecting Their Concentration and Their Physiological Significance. Nestle Nutr Inst Workshop Ser 2019;90:69–81
  6. Pepper MR, Black MM. B12 in fetal development. Semin Cell Dev Biol 2011;22:619–23
  7. Dror DK, Allen LH. Vitamin B-12 in Human Milk: A Systematic Review. Adv Nutr. 2018;9(suppl_1):358S–66S
  8. Sandberg DP, Begley JA, Hall CA. The content, binding, and forms of vitamin B12 in milk. Am J Clin Nutr 1981;34(9):1717– 24
  9. Deegan KL, Jones KM, Zuleta C, Ramirez-Zea M, Lildballe DL, Nexo E, et al. Breast milk vitamin B-12 concentrations in Guatemalan women are correlated with maternal but not infant vitamin B-12 status at 12 months postpartum. J Nutr 2012;142(1):112–6
  10. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington (DC): National Academies Press (US); 1998
  11. Doets EL, In 't Veld PH, Szczecińska A, Dhonukshe-Rutten RA, Cavelaars AE, van 't Veer P, et al. Systematic review on daily vitamin B12 losses and bioavailability for deriving recommendations on vitamin B12 intake with the factorial approach. Ann Nutr Metab 2013;62(4):311–22
  12. Hirai C, Ichiba H, Saito M, Shintaku H, Yamano T, Kusuda S. Trophic effect of multiple growth factors in amniotic fluid or human milk on cultured human fetal small intestinal cells. J Pediatr Gastroenterol Nutr 2002;34(5):524–8
  13. Yesildal F, Koc E, Tas A, Ozgurtas T. Angiopoietins in Human Breast Milk. Breastfeed Med 2016;11:366–9
  14. Hampel D, Shahab-Ferdows S, Islam MM, Peerson JM, Allen LH. Vitamin Concentrations in Human Milk Vary with Time within Feed, Circadian Rhythm, and Single-Dose Supplementa