AI Summary & Key Takeaways
AI InsightWe present a case of prolonged neuromuscular block after mivacurium infusion in an unexpected patient with plasma cholinesterase deficiency whom neuromuscular monitoring was not performed.
📌 3 Key Takeaways
Abstract
Mivacurium chloride is a short-acting, nondepolarizing, bis-benzylisoquinolium neuromuscular blocking drug, metabolized by plasma cholinesterase. Mivacurium has not revealed a cumulative neuromuscular blockade when adminestered to patients with normal plasma cholinesterase activity. It is a suitable drug for the maintenance of neuromuscular blockade due to rapid rate of recovery of patients with normal plasma cholinesterase acti-vitiy. Patients with atypical enzym gene may show extremely prolonged response to mivacurium. We present a case of prolonged neuromuscular block after mivacurium infusion in an unexpected patient with plasma cholinesterase deficiency whom neuromuscular monitoring was not performed.
Özet
Mivakuryum klorid plazma kolinesterazı tarafından metabolize olunan kısa etki süreli, bis-benzylisoquinolium yapısında nondepolarizan bir nöromüsküler bloker drogtur. Mivakuryum normal plazma kolinesterazı olan hastalara uygulandığında birikici etki göstermez. Plazma kolinesterazı olan hastalarda nöromüsküler bloğun idamesinde uygun bir drogtur. Atipik enzim genine sahip hastalar mivacuriuma aşırı uzamış cevap gösterebilirler. Mivakuryum infüzyonu sonrası, nöromüsküler monitörizasyon uygulanmayan, plazma kolines-teraz eksikliği bilinmeyen bir hastada uzamış nöromüsküler blok vakası sunduk.