Journals / Haseki Tıp Bülteni / 2013 / Cilt: 51 - Sayı: 3

Association between obesity and C-reactive protein in type 2 diabetic patients

Diyabetik obez hastalarda obezitenin yüksek duyarlıklı C-reaktif protein (Hs-CRP) ile ilişkisi

Pages
120–124
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Hs-CRP levels were observed to be increased with weight gain.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Obesity is a major health problem causing major illnesses and diseases.
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Key Findings & Data:In this study, we aimed to differentiate type 2 diabetic normal, overweight and obese people to investigate the relationship of obesity with C-reactive protein (Hs-CRP), an inflammatory identifier.
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Conclusion & Impact:Hs-CRP levels were observed to be increased with weight gain.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: Obesity is a major health problem causing major illnesses and diseases. In this study, we aimed to differentiate type 2 diabetic normal, overweight and obese people to investigate the relationship of obesity with C-reactive protein (Hs-CRP), an inflammatory identifier. Methods: The study was conducted on a total of 129 patients (64 female, 65 male) with type 2 diabetes mellitus between May 2010 and September 2010. Study consisted of three groups, classified according to body mass; 16 normal weight, 55 overweight and 58 obese patient. Hs-CRP levels were measured by immunoassay chemiluminescence. All data were statistically analyzed. Results: A significant difference in hs-CRP levels was determined between the groups (p<0.05). Hs-CRP levels in subjects with normal body weight were found to be significantly lower than in obese ones (p<0.05). There was no significant difference in age, cholesterol parameters and HbA1c between the groups. No significant difference was observed in BMI between genders (p<0.05). Based on BMI, the rate of obese women was considerably higher than the rate of overweight and normal women (p<0.05). Similarly, the rate of overweight and normal men was significantly higher than the rate of obese men (p<0.05). Conclusion: Hs-CRP levels in people with normal body weight were confirmed to be significantly lower than those in obese people (p<0.05). Hs-CRP levels were observed to be increased with weight gain.

Özet

Amaç: Obezite diğer hastalıkları da beraberinde getiren önemli bir sağlık sorunudur. Çalışmamızda tip 2 diabetes mellitus (DM) tanısı olan normal, fazla kilolu ve obez olguları ayırıp, obezitenin inflamatuvar bir belirteç olan Hs-CRP üzerine etkisini incelemeyi amaçladık. Yöntem: Çalışma 2010 Mayıs ve 2010 Eylül ayları arasında Diyabet Polikliniği’mize başvuran 64’ü kadın, 65’i erkek tip 2 DM tanılı toplam 129 olgu üzerinde yapıldı. Çalışmaya vücut kitle indeksine (VKİ) göre sınıflandırılan 16 normal kilolu, 55 fazla kilolu, 58 obez toplam üç grup dahil edildi. Hs-CRP kemilüminesan immunoassay ile ölçüldü. Tüm veriler istatistiksel olarak değerlendirildi. Bulgular: Olguların VKİ durumuna göre Hs-CRP ölçüm değerleri arasında istatistiksel olarak anlamlı farklılık saptanmıştır (p<0.05). Normal kilolu olguların Hs-CRP düzeyleri obez olgulardan anlamlı düzeyde düşük olarak saptanmıştır (p<0.05), diğerleri arasında anlamlı fark yoktur. Yaşları, kolesterol parametreleri ve HbA1c arasında anlamlı bir farklılık saptanmamıştır. VKİ’ye göre olguların cinsiyetleri arasında istatistiksel olarak ileri düzeyde anlamlı farklılık saptanmıştır (p<0.05). VKİ obez olan kadın olguların oranı VKİ fazla kilolu ve normal kilolu kadın olguların oranından anlamlı düzeyde yüksektir (p<0.05). Aynı şekilde VKİ fazla kilolu ve normal kilolu erkek olguların oranı vücut kitle indeksi obez olan erkek olguların oranından anlamlı düzeyde yüksektir (p<0.05). Sonuç: Normal kilolu olguların Hs-CRP düzeyleri obez olgulardan anlamlı düzeyde düşük olarak saptanmıştır (p<0.05). Hs-CRP düzeyi kilo artışıyla birlikte artış göstermiştir.

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Cite This Article

BAŞER, M., MAVİŞ, O., ÖZGÜR, R., ÖZDEMİR, A. A., ÖZKESKİN, A., KÜÇÜKDEMİRCİ, Ö., ELİBOL, T. (2013). Association between obesity and C-reactive protein in type 2 diabetic patients. Haseki Tıp Bülteni, Cilt: 51 - Sayı: 3, 120–124. https://ajindex.com/articles/267956

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