Journals / Haseki Tıp Bülteni / 2020 / Cilt: 58 - Sayı: 4

The Effect of Residual Renal Function on Clinical and Laboratory Parameters in Peritoneal Dialysis Patients

Periton Diyalizi Hastalarında Rezidüel Renal Fonksiyonun Klinik ve Laboratuvar Parametrelerine Etkisi

Pages
344–350
DOI
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Conclusion: In our study, the positive effects of RRF on the treatment of anemia, phosphorus control and nutritional status in PD patients were shown.

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Objective & Hypothesis:Aim: To evaluate the effects of residual renal function (RRF) on anemia treatment, phosphorus control and nutritional parameters in peritoneal dialysis (PD) patients.
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Key Findings & Data:Besides anthropometric measurements, biochemical measurements, such as residual glomerular filtration rate (rGFR), normalized protein catabolic rate (nPCR), hemoglobin (Hb), serum albumin, calcium, phosphorus, ferritin, parathormone and C-reactive protein levels were recorded.
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Conclusion & Impact:Conclusion: In our study, the positive effects of RRF on the treatment of anemia, phosphorus control and nutritional status in PD patients were shown.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: To evaluate the effects of residual renal function (RRF) on anemia treatment, phosphorus control and nutritional parameters in peritoneal dialysis (PD) patients. Methods: PD patients were retrospectively analyzed. Besides anthropometric measurements, biochemical measurements, such as residual glomerular filtration rate (rGFR), normalized protein catabolic rate (nPCR), hemoglobin (Hb), serum albumin, calcium, phosphorus, ferritin, parathormone and C-reactive protein levels were recorded. Results: One hundred and fifteen patients (52 females, 63 males; mean age: 56.0±13.2 years 20-83 years) receiving PD treatment were analyzed. The patients were divided into two groups according to presence or absence of RRF (n=75 and n=40, respectively). Patients with RRF had higher body weight (80±14 kg vs 68±13 kg; p<0.001), body mass index (29±5 kg/ m² vs 25±5 kg/m²; p=0.009) and serum albumin level (3.6±0.5 vs 3.4±0.5 g/dL; p=0.027]. Patients with RRF had lower erythropoietin [29 (39%), vs. 34 (85%); p<0.001), sevelamer [17 (22.7%) vs 24 (60%); p<0.001] and calcimimetic [9 (12%) vs 14 (35%); p=0.007] usage rates and lower ferritin [159 (88-259) ng/mL vs 323 (170-495) ng/mL; p=0.001] level. rGFR was found to be positively correlated with Hb (r=0.274; p=0.017) and nPCR in patients with RRF (r=0.251; p=0.030). Conclusion: In our study, the positive effects of RRF on the treatment of anemia, phosphorus control and nutritional status in PD patients were shown.

Özet

Amaç: Periton diyalizi (PD) hastalarında rezidüel renal fonksiyonun (RRF) anemi tedavisi, fosfor kontrolü ve beslenme parametreleri üzerindeki etkilerini değerlendirmektir. Yöntemler: PD hastaları retrospektif olarak incelendi. Antropometrik ölçümlerin yanında, rezidüel glomerüler filtrasyon hızı (rGFH), normalize protein katabolik hızı (nPCR), hemoglobin (Hb), serum albümin, kalsiyum, fosfor, ferritin, parathormon ve C-reaktif protein düzeylerini içeren biyokimyasal ölçümler kaydedildi. Bulgular: PD tedavisi alan 115 hasta (52 kadın, 63 erkek; ortalama yaş 56,0±13,2 yıl, 20-83 yıl) analiz edildi. Hastalar RRF’nin olmasına (n=75) ve olmamasına (n=40) göre iki gruba ayrıldı. RRF’si olan hastalar daha yüksek vücut ağırlığı (80±14 kg vs 68±13 kg; p<0,001), vücut kitle indeksi (29±5 kg/m² vs 25±5 kg/m²; p=0,009) ve serum albümin (3,6±0,5 vs 3,4±0,5 g/dL; p=0,027) seviyelerine sahipti. RRF’li hastalar, sırasıyla daha az eritropoetin [29 (%39) vs 34 (%85); p<0,001], sevelamer [17 (%22,7) vs 24 (%60); p<0,001] ve kalsimimetik [9 (%12) vs 14 (%35); p=0,007] kullanım oranına ve daha düşük ferritin [159 (88-259) ng/mL vs 323 (170-495) ng/mL; p=0,001] düzeyine sahiptiler. RRF’li hastalarda rGFH’nin, Hb (r=0,274; p=0,017) ve nPCR (r=0,251; p=0,030) ile pozitif korelasyon gösterdiği görüldü. Sonuç: Çalışmamızda PD hastalarında RRF’nin, anemi tedavisine, fosfor kontrolüne ve beslenme belirteçlerine olan olumlu etkileri gösterildi.

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Cite This Article

DÜŞÜNCELİ, İ. H., ERGÜL, M., EREN, N., KALENDER, B. G., DERVİŞOĞLU, E. (2020). The Effect of Residual Renal Function on Clinical and Laboratory Parameters in Peritoneal Dialysis Patients. Haseki Tıp Bülteni, Cilt: 58 - Sayı: 4, 344–350. https://ajindex.com/articles/267779

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