SavedAdd your journal

Journals / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2019 / Cilt: 9 - Sayı: 4

Rumex crispus Extract Exerts Anti-Diabetic Properties in Streptozotocin-Induced Diabetes in Rats

Rumex crispus Ekstraktı Sıçanlarda Streptozotosin ile Oluşturulan Diyabette Anti-Diyabetik Özellikler Gösterir

Özgen ÇELİK
Evren KOÇ
Pages
1937–1943
Publication Date
2019-12-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was found that R. crispus extract reduced diabetes-related weight loss and blood glucose levels 10 days after the formation of diabetes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Rumex crispus is a natural, wild plant that grows spontaneously on riverside and wet meadows, and has been used for centuries in alternative medicine.
📊
Key Findings & Data:The animals were divided into 4 groups.
💡
Conclusion & Impact:It was found that R. crispus extract reduced diabetes-related weight loss and blood glucose levels 10 days after the formation of diabetes.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Diyabet · lipit profili · karaciğer enzimleri

Abstract

Rumex crispus is a natural, wild plant that grows spontaneously on riverside and wet meadows, and has been used for centuries in alternative medicine. In the present study, the effects of R. crispus on body weights, fasting blood glucose levels, plasma lipid profile, liver enzyme activities and antioxidant system were investigated in streptozotocin (STZ) induced diabetic rats. The animals were divided into 4 groups. Group I: control; group II: 3 mg kg-1 R. crispus; group III: 50 mg kg-1 Streptozotocin (STZ)-induced diabetes; group IV: 50 mg kg-1 STZ-induced diabetes + 3 mg kg-1 R.crispus. It was found that R. crispus extract reduced diabetes-related weight loss and blood glucose levels 10 days after the formation of diabetes. At the end of 14-day treatment period, HDL cholesterol (HDL-C) levels significantly decreased (P<0.01) while triglyceride, LDL cholesterol (LDL-C) and VLDL cholesterol (VLDL-C) levels increased in R. crispus supplemented diabetic rats (P<0.001). The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly increased in response to R. crispus (P <0.001). Total antioxidant status (TAS) significantly decreased and total oxidant status (TOS) increased in diabetic group; however, in response to R. crispus treatment, TAS significantly increased and TOS decreased relative to control group (P<0.001, for both). Supplementation of R. crispus extract shows anti-diabetic properties in rats and might have a clinical potential for diabetic individuals.

Özet

Rumex crispus, nehir kenarı ve ıslak çayırlarda kendiliğinden yetişen ve alternatif tıpta yüzyıllardır kullanılan doğal, yabani bir bitkidir. Bu çalışmada, streptozotosin (STZ) aracılığıyla diyabet oluşturulan sıçanlarda R. crispus'un canlı ağırlıkları, açlık kan glukoz seviyeleri, plazma lipid profili, karaciğer enzim aktiviteleri ve antioksidan sisteme etkileri araştırıldı. Hayvanlar 4 gruba ayrıldı. I. grup: kontrol; II. grup: 3 mg kg-1 R. crispus; grup III: 50 mg kg-1 Streptozotosin (STZ) ile diyabet oluşturulan grup; grup IV: 50 mg kg-1 STZ ile diyabet oluşturulan + 3 mg kg-1 R. crispus uygulanan grup şeklinde belirlendi. R. crispus ekstraktının, diyabet oluşumundan 10 gün sonra diyabete bağlı ağırlık kaybını ve kan glikoz seviyesini azalttığı tespit edildi. 14 günlük uygulama süresinin sonunda, R. crispus uygulanan diyabetik sıçanlarda trigliserit, LDL kolesterol (LDL-C) ve VLDL kolesterol (VLDL-C) düzeyleri artarken (P<0.001), HDL kolesterol (HDL-C) seviyeleri anlamlı derecede azaldı (P<0.01). Alanin aminotransferaz (ALT) ve aspartat aminotransferaz (AST) seviyeleri, R. crispus'a cevaben önemli ölçüde artmıştır (P<0.001). Diyabetik grupta total antioksidan seviye (TAS) anlamlı derecede azalırken, total oksidan seviyenin (TOS) artış gösterdiği belirlendi. Bununla birlikte, R. crispus tedavisine cevap olarak, TAS anlamlı şekilde artmış ve TOS kontrol grubuna göre azalmıştır (her ikisi için de P<0.001). R. crispus ekstraktının takviyesi, sıçanlarda anti-diyabetik özellikler gösterir ve diyabetik bireyler için klinik bir potansiyele sahip olabilir.

🔖

Cite This Article

ÇELİK, Ö., KOÇ, E. (2019). Rumex crispus Extract Exerts Anti-Diabetic Properties in Streptozotocin-Induced Diabetes in Rats. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 9 - Sayı: 4, 1937–1943. https://ajindex.com/articles/257434

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Alezandro MR, Granato D, Genovese MI, 2013. Jaboticaba (Myrciaria jaboticaba (Vell.) Berg), a Brazilian Grape-Like Fruit, Improves Plasma Lipid Profile in Streptozotocin-Mediated Oxidative Stress in Diabetic Rats. Food Research International, 54: 650–659.
  2. Aouacheri O, Saka S, Krim M, Messaadia A, Maidi I, 2015. The Investigation of the Oxidative Stress-Related Parameters in Type 2 Diabetes Mellitus. Canadian Journal of Diabetes, 39: 44–49.
  3. Atila G, Uslu H, Beytut E, Koç E, Ersan Y, 2015.
  4. Anti-Hyperglycaemic, Anti-Oxidant and Anti-Hyperlipidaemic Effects of Momordica charantia L. on Streptozotocin-Induced Diabetic Rats. Indian Journal of Traditional Knowledge, 14: 382–386.
  5. Caner C, Özeç AV, Aydın H, Topalkara A, Arıcı MK, Erdoğan H, Toker Mİ, 2012.
  6. Comparison of Total Oxidative Stress, Total Antioxidant Capacity, Paraoxonase, Arylesterase, Lipid Peroxidase Levels in Humor Aquos and Serum at Diabetic and Nondiabetic Patients with Cataract. Turkish Journal of Ophthalmology, 42: 47–52.
  7. Coruh I, Gormez A, Ercisli S, Sengul M, 2008.
  8. Total Phenolic Content, Antioxidant, and Antibacterial Activity of Rumex crispus Grown Wild in Turkey. Pharmaceutical Biology, 46: 634–638.
  9. Degirmenci I, Ustuner MC, Kalender Y, Kalender S, Gunes HV, 2005. The Effects of Acarbose and Rumex patientia L. on Ultrastructural and Biochemical Changes of Pancreatic B Cells in Streptozotocin-Induced Diabetic Rats. Journal of Ethnopharmacology, 97: 555–559.
  10. Elzaawely AA, Tawata S, 2012. Antioxidant Capacity and Phenolic Content of Rumex dentatus L. Grown in Egypt. Journal of Crop Science and Biotechnology, 15: 59–64.
  11. Ha BG, Yonezawa T, Son MJ, Woo JT, Ohba S, Chung U-I, Yagasaki K, 2014.
  12. Antidiabetic Effect of Nepodin, A Component of Rumex Roots, and its Modes of Action in Vitro and In vivo. BioFactors, 40: 436–447.
  13. Hamdan II, Afifi FU, 2004. Studies on the In vitro and In vivo Hypoglycemic Activities of Some Medicinal Plants Used in Treatment of Diabetes in Jordanian Traditional Medicine. Journal of Ethnopharmacology, 93: 117–121.
  14. Kim HJ, Jung CL, Park IS, Suh H-J, Kwon OO, Kim J-S, 2013. Nrf2-Mediated Induction of Phase 2 Detoxifying Enzymes by Curled dock (Rumex crispus L.) Seed Extract. Food Science and Biotechnology, 22: 795–802.
  15. Lupi R, Del Guerra S, Mancarella R, Novelli M, Valgimigli L, Pedulli GF, Paolini M, Soleti A, Filipponi F, Mosca F, 2007. Insulin Secretion Defects of Human Type 2 Diabetic Islets are Corrected In vitro by A New Reactive Oxygen Species Scavenger. Diabetes & Meta