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Journals / Gazi University Journal of Science / 2011 / Cilt: 24 - Sayı: 3

Chlorpyrifos Induced Cardiotoxicity in Rats and the Protective Role of Quercetin and Catechin

Hatice BAS
Yusuf KALENDER
Pages
387–395
Publication Date
2011-11-25
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, catechin and quercetin significantly reduce chlorpyrifos induced cardiotoxicity in rats, but they aren’t protect completely.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, chlorpyrifos, catechin, quercetin and catechin- or quercetin+chlorpyrifos were given to Wistar rats for 4 weeks.
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Key Findings & Data:Chlorpyrifos increased the levels of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT); decreased glutathione peroxidase (GPx) and glutathione–S-transferase (GST) activities in heart compared to the control.
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Conclusion & Impact:As a result, catechin and quercetin significantly reduce chlorpyrifos induced cardiotoxicity in rats, but they aren’t protect completely.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Chlorpyrifos · Flavonoids · Antioxidant Enzymes

Abstract

In this study, chlorpyrifos, catechin, quercetin and catechin- or quercetin+chlorpyrifos were given to Wistar rats for 4 weeks. Chlorpyrifos increased the levels of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT); decreased glutathione peroxidase (GPx) and glutathione–S-transferase (GST) activities in heart compared to the control. In catechin- and quercetin+chlorpyrifos groups, we observed the protective effects of flavonoids on examining parameters. Light microscopic investigations revealed that chlorpyrifos induced histopathological alterations in heart. Milder histopathological changes were observed co-treated with catechin- or quercetin+chlorpyrifos. As a result, catechin and quercetin significantly reduce chlorpyrifos induced cardiotoxicity in rats, but they aren’t protect completely.

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Cite This Article

BAS, H., KALENDER, Y. (2011). Chlorpyrifos Induced Cardiotoxicity in Rats and the Protective Role of Quercetin and Catechin. Gazi University Journal of Science, Cilt: 24 - Sayı: 3, 387–395. https://ajindex.com/articles/255540

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