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Journals / Gazi University Journal of Science / 2013 / Cilt: 26 - Sayı: 1

Synthesis, Characterization and the Photodynamic Activity against Some Gram negative and positive Bacteria of Novel Subphthalocyanine Derivative

Bircan DİNDAR
Mine INCE
Özlem SEVEN
Pages
1–10
Publication Date
2013-03-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This new amphiphilic macromolecule was especially found as an effective photosensitizer against gram positive bacteria in PDT, in particular.

📌 3 Key Takeaways

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Objective & Hypothesis:A specific tris(3,5-di-tert-butyl-4-hydroxyphenyl)Subphthalocyaninehydroxyde (SubPc-1) derivative was synthesized and the structure of SubPc-1 was confirmed by UV-Vis, Fluorescence, FTIR, 1H NMR, 13C NMR and MALDI-TOF-MS spectroscopy.
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Key Findings & Data:In addition, the singlet oxygen produced capacity of amphiphilic SubPc-1 was determined for PDT studies.
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Conclusion & Impact:This new amphiphilic macromolecule was especially found as an effective photosensitizer against gram positive bacteria in PDT, in particular.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Subphthalocyanine · photosensitizer · biological activity

Abstract

A specific tris(3,5-di-tert-butyl-4-hydroxyphenyl)Subphthalocyaninehydroxyde (SubPc-1) derivative was synthesized and the structure of SubPc-1 was confirmed by UV-Vis, Fluorescence, FTIR, 1H NMR, 13C NMR and MALDI-TOF-MS spectroscopy. Its thermal stability and photostability tests were checked by using TGA and solar simulator, respectively. In addition, the singlet oxygen produced capacity of amphiphilic SubPc-1 was determined for PDT studies. Besides, the photodynamic activity of this novel product against some of gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and gram positive bacteria (Staphylococus aureus, Enterococcus faecalis) has been investigated by using a xenon lamp which emits light in the ultraviolet-visible region and is simulated for solar light as the illumination source. It was determined that the peripheral hydrophilic groups provided great opportunities in inactivation and solubility studies. This new amphiphilic macromolecule was especially found as an effective photosensitizer against gram positive bacteria in PDT, in particular.

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Cite This Article

DİNDAR, B., INCE, M., SEVEN, Ö. (2013). Synthesis, Characterization and the Photodynamic Activity against Some Gram negative and positive Bacteria of Novel Subphthalocyanine Derivative. Gazi University Journal of Science, Cilt: 26 - Sayı: 1, 1–10. https://ajindex.com/articles/255408

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