An efficient synthesis of 3-aryl-2-cyclohexylamino-6,7-dihydro-1H-indole-4(5H)-ones using ferric perchlorate as the catalyst via four-component reaction between cyclohexylisocyanide, an aldehyde, a cyclic 1,3-dicarbonyl compound and ammonium acetate in acetonitrile is described.Key Words: cyclohexylisocyanide, cyclic 1,3-dicarbonyl compound, multi-component reaction;1H-Indole-4(5H)-ones.
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Objective & Hypothesis:An efficient synthesis of 3-aryl-2-cyclohexylamino-6,7-dihydro-1H-indole-4(5H)-ones using ferric perchlorate as the catalyst via four-component reaction between cyclohexylisocyanide, an aldehyde, a cyclic 1,3-dicarbonyl compound and ammonium acetate in acetonitrile is described.Key Words: cyclohexylisocyanide, cyclic 1,3-dicarbonyl compound, multi-component reaction;1H-Indole-4(5H)-ones.
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Key Findings & Data:An efficient synthesis of 3-aryl-2-cyclohexylamino-6,7-dihydro-1H-indole-4(5H)-ones using ferric perchlorate as the catalyst via four-component reaction between cyclohexylisocyanide, an aldehyde, a cyclic 1,3-dicarbonyl compound and ammonium acetate in acetonitrile is described.Key Words: cyclohexylisocyanide, cyclic 1,3-dicarbonyl compound, multi-component reaction;1H-Indole-4(5H)-ones.
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Conclusion & Impact:An efficient synthesis of 3-aryl-2-cyclohexylamino-6,7-dihydro-1H-indole-4(5H)-ones using ferric perchlorate as the catalyst via four-component reaction between cyclohexylisocyanide, an aldehyde, a cyclic 1,3-dicarbonyl compound and ammonium acetate in acetonitrile is described.Key Words: cyclohexylisocyanide, cyclic 1,3-dicarbonyl compound, multi-component reaction;1H-Indole-4(5H)-ones.
An efficient synthesis of 3-aryl-2-cyclohexylamino-6,7-dihydro-1H-indole-4(5H)-ones using ferric perchlorate as the catalyst via four-component reaction between cyclohexylisocyanide, an aldehyde, a cyclic 1,3-dicarbonyl compound and ammonium acetate in acetonitrile is described.Key Words: cyclohexylisocyanide, cyclic 1,3-dicarbonyl compound, multi-component reaction;1H-Indole-4(5H)-ones.
BAGHERNEJAD, B., OSKOOIE, H. A., HERAVI, M. M. (2010). Ferric Perchlorate-Catalyzed Multicomponent Synthesis of 3-aryl-2-cyclohexylamino-6,7-dihydro -1H-indole- 4(5H)-ones. Gazi University Journal of Science, Cilt: 23 - Sayı: 1, 27–32. https://ajindex.com/articles/255042