BIOLOGICAL ACTIVITY STUDIES OF SOME SYNTHESIZED NOVEL FURAN AND PYRAN DERIVATIVES

Objective & Hypothesis:In this study, some novel furan and pyran derivatives 1-[4-(1-hydroxyethyl)-2-methyl-5-phenyl-4,5 dihydrofuran-3-il]ethanone (1); 1-(4-Hydroxymethyl-5,5-dimethyl-2-phenyl-4,5-dihydro-furan-3-il)ethanone (2); Ethyl 2-methyl-5-phenyl-5-styryl-4,5-dihydro-furan-3-carboxylate (3); Ethyl 4-hydroxymethyl-2,5,5-trimethyl-4,5-dihydro-furan-3-carboxylate (4); Ethyl 4-(1-hydroxy-ethyl)-2-methyl-5-phenyl-4,5-dihydro-furan-3-carboxylate (5) Ethyl 5-hydroxy-2,6,6-trimethyl-5,6-dihydro-4H-pyran-3-carboxylate (6) were synthesized as mentioned in our previous report [1].

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Key Findings & Data:Bacillus licheniformis M30 , Bacillus megaterium M22, Bacillus circulans M34, Bacillus subtilis B1 , Bacillus subtilis M33 , Bacillus cereus B9, Staphylococcus aureus ATCC 653, Micrococcus luteus M3 and gram-negative i.e.

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Conclusion & Impact:Their antibiogram tests showed better results than some known antibiotics.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Antibacterial Activity · Antifungal Activity · Furan

Abstract

In this study, some novel furan and pyran derivatives 1-[4-(1-hydroxyethyl)-2-methyl-5-phenyl-4,5 dihydrofuran-3-il]ethanone (1); 1-(4-Hydroxymethyl-5,5-dimethyl-2-phenyl-4,5-dihydro-furan-3-il)ethanone (2); Ethyl 2-methyl-5-phenyl-5-styryl-4,5-dihydro-furan-3-carboxylate (3); Ethyl 4-hydroxymethyl-2,5,5-trimethyl-4,5-dihydro-furan-3-carboxylate (4); Ethyl 4-(1-hydroxy-ethyl)-2-methyl-5-phenyl-4,5-dihydro-furan-3-carboxylate (5) Ethyl 5-hydroxy-2,6,6-trimethyl-5,6-dihydro-4H-pyran-3-carboxylate (6) were synthesized as mentioned in our previous report [1]. The in vitro novel furan and pyran derivatives were investigated for antibacterial activity against gram-positive bacteria i.e. Bacillus licheniformis M30 , Bacillus megaterium M22, Bacillus circulans M34, Bacillus subtilis B1 , Bacillus subtilis M33 , Bacillus cereus B9, Staphylococcus aureus ATCC 653, Micrococcus luteus M3 and gram-negative i.e. Escherichia coli ATCC 25922 , and as a fungus Pseudomonas aeruginosa P7. The antibacterial and antifungal activities were determined by the disc diffusion method (DISC) and minimum inhibition concentration (MIC) against the tested gram-positive and gram-negative bacteria and fungus. The inhibition zones were compared with those of reference discs which were studied in our previous work [2]. Reference discs used for control were as follows ketoconazole, ampicillin, tetracycline, penicillin, chloramphenicol, and gentamicin. From the results it could be said that some of the chemical compound can be used as a raw medicine sources. Their antibiogram tests showed better results than some known antibiotics.

Keywords

Antibacterial Activity Antifungal Activity Furan Pyran

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Cite This Article

SARİ, E., ASLAN, H., DADI, Ş., ÖKTEMER, A., LOĞOĞLU, E. (2017). BIOLOGICAL ACTIVITY STUDIES OF SOME SYNTHESIZED NOVEL FURAN AND PYRAN DERIVATIVES. Gazi University Journal of Science, Cilt: 30 - Sayı: 4, 49–55. https://ajindex.com/articles/254864

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