As a result, sodium selenite significantly reduces lead nitrate induced testicular toxicity both groups.
📌 3 Key Takeaways
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Objective & Hypothesis:In this study, diabetic and non-diabetic male rats were given to sodium selenite, lead nitrate and sodium selenite plus lead nitrate through gavage.
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Key Findings & Data:At the end of the 4th week, lipid peroxidation and antioxidant enzyme activities was investigated compared to control group.
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Conclusion & Impact:As a result, sodium selenite significantly reduces lead nitrate induced testicular toxicity both groups.
In this study, diabetic and non-diabetic male rats were given to sodium selenite, lead nitrate and sodium selenite plus lead nitrate through gavage. At the end of the 4th week, lipid peroxidation and antioxidant enzyme activities was investigated compared to control group. No significant differences were observed between control and sodium selenite treated groups. By the end of the fourth week, lead nitrate led to increase the levels of MDA, and decrease in antioxidant activities compared with the control group in diabetic and non-diabetic rats. As a result, sodium selenite significantly reduces lead nitrate induced testicular toxicity both groups.
APAYDIN, F., KALENDER, S., DEMİR, F., BAŞ, H. (2014). Effects of Sodium Selenite Supplementation on Lead Nitrate-induced Oxidative Stress in Lung Tissue of Diabetic and Non-diabetic Rats. Gazi University Journal of Science, Cilt: 27 - Sayı: 2, 847–853. https://ajindex.com/articles/254832
Shabani, A., Rabbani, A., “Lead nitrate induced apoptosis in alveolar macrophages from rat lung”, Toxicology 149: 109-114, (2000).
Khalaf, A.A., Moselhy, W.A., Abdel-Hamed, M.I., “The protective effect of green tea extract on lead induced oxidative and DNA damage on rat brain”. Neorotoxicity 33: 280-289, (2012).
Liu, M., Xu, Y., Chen, Y., Li, J., Zhao, F., Zheng, G., Jing, J., Ke, T., Chen, J., Luo, W., “The effect of sodium selenite on lead induced cognitive dysfunction”, Neurotoxicology 36: 82-88 (2013).
Moreira, E.G., Rosa, G.J.M., Barros, S.B.M., Vassilieff, V.S., Vassilieff I., “Antioxidant defense in rat brain regions after developmental lead exposure”, Toxicology 169: 145–151, (2001).
Ercal, N., Neal, R., Treeratphan, P., Lutz, P.M., Hammond, T.C., Dennery, P.A., Spitz, D.R., “A role for immunoglobulin levels in lead-exposed Fisher 344 rats”, Arch. Environ. Contam. Toxicol. 39: 251–256, (2000). suppressing serum Shalan, M.G., Mostafa, M.S., Hassouna, M.M., El,Nabi, S.E.H., El-Rafeie, A., “Amelioration of lead toxicity on rat liver with Vitamin C and silymarin supplements”, Toxicology 206: 1–15, (2005).
Mousa, H.M., Al-Qarawi, A.A., Ali, B.H., Abdel Rahman, H.A., ElMougy, S.A., “Effect of lead exposure on the erythrocytic antioxidant levels in goats”, J. Vet. Med. A 49: 531–534 (2002).
Berrahal, A.A., Nehdi, A., Hajjaji, N., Gharbi, N., El- Fazaa, S., “Antioxidant enzymes activities and bilirubin level in adult rat treated with lead”, C.R. Biologies 330, 581-588, (2007).
El-Neweshy, M.S., El-Sayed, Y.S., “Influence of supplementation vitamin C on lead-induced histopathological Experimental and Toxicologic Pathology 63: 221- 227 (2011). in male rats”, Jihen, E., Imed, M., Fatima, H., Abdelhamid, K., “Protective effects of selenium (Se) and Zinc (Zn) on cadmium (Cd) toxicity in the liver of the rat: Effects on the oxidative stress”, Ecotoxicology and Environmental Safety 72: 1559-1564 (2009).
Kalender, S., Uzun, F.G., Demir, F., Uzunhisarcikli, M., Aslanturk., A., “Mercuric chloride-induced testicular toxicity in rats and the protective role of sodium selenite and vitamin E”. Food Chem Toxicol, 55: 456-462 (2013).
Prabhakar, P.K., Kumar, A., Doble, M., “Combination therapy: A new strategy to manage diabetes and its complications”, Phytomedicine 21:123-130 (2014).
Shilo, S., Aronis, A., Komarnitsky, R., Tirosh, O., “Selenite sensitizes mitochondrial permeability transition pore opening in vitro and in vivo: a possible mechanism for chemo-protection”, Bi